Results 71 to 80 of about 87,091 (210)

Advanced Glycation End Products in Clinical Nephrology

Kidney and Blood Pressure Research, 2004
As a result of oxidative and carbonyl stress, advanced glycation end products (AGEs) are involved in the pathogenesis of severe and frequent diseases and their fatal vascular/cardiovascular complications, i.e. diabetes mellitus and its complications (nephropathy, angiopathy, neuropathy and retinopathy, renal failure and uremic and dialysis-associated ...
M, Kalousová, T, Zima, V, Tesar, S, Stípek, S, Sulková   +4 more
openaire   +2 more sources

Toxicity of advanced glycation end products (Review)

Biomedical Reports, 2021
Advanced glycation end-products (AGEs) are proteins or lipids glycated nonenzymatically by glucose, or other reducing sugars and their derivatives, such as glyceraldehyde, glycolaldehyde, methyloglyoxal and acetaldehyde. There are three different means of AGE formation: i) Maillard reactions, the polyol pathway and lipid peroxidation.
openaire   +4 more sources

Oxidative stress, protein glycation and nutrition – interactions relevant to health and disease throughout the lifecycle [PDF]

, 2014
Protein glycation has been studied for over a century now and plays an important role in disease pathogenesis throughout the lifecycle. Strongly related to diabetic complications, glycation of Hb has become the gold standard method for diabetes diagnosis
American Diabetes, Antonis Vlassopoulos, Bhagwat, El-Salem, Emilie Combet, Hao, Hodge, Khaw, Koenig, Maillard, Malickova, Michael E. J. Lean, Monnier, Nicholl, Rothwell, Schmidt, Sell, Vlassara   +17 more
core   +3 more sources

Advanced glycation end products and diabetic retinopathy [PDF]

Journal of Ocular Biology, Diseases, and Informatics, 2012
Studies have established hyperglycemia as the most important factor in the progress of vascular complications. Formation of advanced glycation end products (AGEs) correlates with glycemic control. The AGE hypothesis proposes that hyperglycemia contributes to the pathogenesis of diabetic complications including retinopathy.
Yashodhara, Sharma, Sandeep, Saxena, Arvind, Mishra, Anita, Saxena, Shankar Madhav, Natu   +4 more
openaire   +2 more sources

Receptor for advanced glycation end products and its involvement in inflammatory diseases [PDF]

, 2013
The receptor for advanced glycation end products (RAGE) is a transmembrane receptor of the immunoglobulin superfamily, capable of binding a broad repertoire of ligands. RAGE-ligands interaction induces a series of signal transduction cascades and lead to
Basir, Rusliza, Chuah, Yaw Kuang, Nordin, Norshariza, Talib, Herni, Tie, Tung Hing   +4 more
core   +3 more sources

Opposing effects of bisphosphonates and advanced glycation end-products on osteoblastic cells [PDF]

, 2008
Patients with long-standing Diabetes mellitus can develop osteopenia and osteoporosis. We have previously shown that advanced glycation endproducts reduce the bone-forming activity of osteoblasts.
Arnol, Verónica, Cortizo, Ana María, Felice, Juan Ignacio, Gangoiti, María Virginia, McCarthy, Antonio Desmond   +4 more
core   +2 more sources

Advanced glycation end products and human diseases

Journal of Biological Research
Proteins, lipids, and nucleic acids can undergo non-enzymatic glycation and oxidation, leading to the formation of Advanced Glycation End products (AGEs).
Hamad Abu Zahra
doaj   +1 more source

Research Progress on Natural Products Inhibiting Advanced Glycation End Products [PDF]

Shipin Kexue
Glycation is the non-enzymatic reaction between sugars (glucose and fructose) and proteins or lipids, giving rise to the formation of advanced glycation end products (AGEs).
QI Yawei, LIU Haochi, LIU Jifeng
doaj   +1 more source

Advanced glycation end-products: Mechanics of aged collagen from molecule to tissue [PDF]

, 2017
Concurrent with a progressive loss of regenerative capacity, connective tissue aging is characterized by a progressive accumulation of Advanced Glycation End-products (AGEs).
Andreassen, Ansari, Avery, Bailey, Bedi, Cheng, Del Turco, Dressler, Dyer, Fessel, Fessel, Fessel, Fratzl, Gautieri, Gautieri, Gautieri, Goh, Goh, Grandhee, Gupta, Hansen, Kraft, Lavagnino, Li, Li, Meier, Monnier, Nagaraj, Nair, Reddy, Reigle, Rigoldi, Sasaki, Schnider, Sell, Sell, Sensi, Slatter, Snedeker, Sroga, Su, Su, Svensson, Svensson, Szczesny, Szczesny, Tanaka, Tang, Tang, Thorpe, Toyama, Vashishth, Verzijl, Verzijl, Vesentini, Vincent, Willett, Wu, Yamagishi, Zimmermann   +59 more
core   +1 more source

Targeting RAGE prevents muscle wasting and prolongs survival in cancer cachexia [PDF]

, 2020
Background: Cachexia, a multifactorial syndrome affecting more than 50% of patients with advanced cancer and responsible for ~20% of cancer-associated deaths, is still a poorly understood process without a standard cure available. Skeletal muscle atrophy
Chiappalupi, S., Coletti, D., Donato, R., Renga, G., Riuzzi, F., Romani, L., Sagheddu, R., Salvadori, L., Sorci, G., Vukasinovic, A.   +9 more
core   +1 more source