Results 81 to 90 of about 58,432 (298)
Vascular Effects of Dietary Advanced Glycation End Products
International Journal of Endocrinology, 2015 Evidence has accumulated lately demonstrating that advanced glycation end products (AGEs) play an important role in the development of diabetic and cardiovascular complications as well as the development of other chronic diseases.
Alin Stirban, Diethelm Tschöpe
doaj +1 more source
Advanced glycation end products, dementia, and diabetes [PDF]
Proceedings of the National Academy of Sciences, 2014 It is becoming abundantly clear that the insight into the pathological process of Alzheimer’s disease (AD) provided through autosomal dominant variants of the condition is only a partial one. The formation and aggregation of Aβ and the phosphorylation and aggregation of tau are clearly part of the core pathogenesis.
Simon, Lovestone, Ulf, Smith
openaire +2 more sources
, 2017 Diabetic myopathy, a less studied complication of diabetes, exhibits the clinical observations characterized by a less muscle mass, muscle weakness and a reduced physical functional capacity.
蔡克嵩;楊庭華;詹鼎正;劉興華;姜至剛;楊榮森 +1 more
core +1 more source
Animal Models and Experimental Medicine, EarlyView.ErZhi formula (EZF) is composed of Ligustri Lucidi Fructus (LLF) and Ecliptae herba (EH). Ovariectomized (OVX) and sham rats received 12‐week intragastric treatment with EZF, alendronate, and vehicle saline. Gastrocnemius tissues were harvested to systematically evaluate pharmacodynamic changes in skeletal muscle morphology, mitochondrial ...
Yuqing Pang +7 more
wiley +1 more source
Advanced Glycation End Products in the Pathogenesis of Psoriasis [PDF]
International Journal of Molecular Sciences, 2017 Advanced glycation end products (AGEs) are extremely oxidant and biologically reactive compounds, which form through oxidation of sugars, lipids and amino acids to create aldehydes that bind covalently to proteins. AGEs formation and accumulation in human tissues is a physiological process during ageing but it is enhanced in case of persistent ...
Papagrigoraki, Anastasia +4 more
openaire +3 more sources
Late‐Stage Functionalization of Peptides on the Solid Phase
Angewandte Chemie International Edition, EarlyView.Peptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Marius Werner +2 more
wiley +1 more source
The Chemistry of Advanced Glycation End-products [PDF]
, 2018 Glycation is the most general IUPAC term used to describe a non-enzymatic reaction between a sugar and another biomolecule. Moreover, the term glycation describes not only the reaction per se but also the sequence of non-enzymatic reactions in which ...
Marília Oliveira Fonseca Goulart +9 more
core +1 more source
Biomaterial design strategies for enhancing mitochondrial transplantation therapy
BMEMat, EarlyView.Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang +12 more
wiley +1 more source
, 2010 The sRAGE [soluble RAGE (receptor for advanced glycation end-products)] lack the transmembrane and cytoplasmic domain of the full-length receptor and can function as a decoy for RAGE ligands.
D. John Betteridge +11 more
core +1 more source
BMEMat, EarlyView.The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang +6 more
wiley +1 more source