Advanced Glycation End-Products (AGEs): Formation, Chemistry, Classification, Receptors, and Diseases Related to AGEs [PDF]
Cells, 2022 Advanced glycation end-products (AGEs) constitute a non-homogenous, chemically diverse group of compounds formed either exogeneously or endogeneously on the course of various pathways in the human body.
Aleksandra Twarda-Clapa +3 more
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Advanced glycation end products regulate the receptor of AGEs epigenetically [PDF]
Frontiers in Cell and Developmental Biology, 2023 Advanced glycation end-products (AGEs) can boost their receptor of AGE (RAGE) expression through the downstream signaling pathway to facilitate AGE–RAGE interaction. In this regulation process, the primary signaling pathways are NF-κB and STAT3. However,
Xiaoqing Wu +4 more
doaj +4 more sources
Pharmacologic approaches against Advanced Glycation End Products (AGEs) in diabetic cardiovascular disease [PDF]
Research in Cardiovascular Medicine, 2015 Context: Advanced Glycation End-Products (AGEs) are signaling proteins associated to several vascular and neurological complications in diabetic and non-diabetic patients.
Antonio Nenna +6 more
doaj +4 more sources
The Possible Mechanism of Advanced Glycation End Products (AGEs) for Alzheimer's Disease. [PDF]
PLoS ONE, 2015 Amyloid precursor protein (APP) has been modified by β and γ-secretase that cause amyloid deposits (plaques) in neuronal cells. Glyceraldhyde-derived AGEs has been identified as a major source of neurotoxicity in Alzheimer's disease (AD).
Shun-Yao Ko +7 more
doaj +6 more sources
Advanced Glycation End Products (AGEs) and Chronic Kidney Disease: Does the Modern Diet AGE the Kidney? [PDF]
Nutrients, 2022 Since the 1980s, chronic kidney disease (CKD) affecting all ages has increased by almost 25%. This increase may be partially attributable to lifestyle changes and increased global consumption of a “western” diet, which is typically energy dense, low in ...
Fotheringham AK +3 more
europepmc +2 more sources
The advanced glycation end-products (AGEs)/ROS/NLRP3 inflammasome axis contributes to delayed diabetic corneal wound healing and nerve regeneration. [PDF]
Int J Biol Sci, 2022 Diabetic keratopathy (DK) is an important diabetic complication at the ocular surface. Chronic low-grade inflammation mediated by the NLRP3 inflammasome promotes pathogenesis of diabetes and its complications.
Wan L +8 more
europepmc +2 more sources
Advanced Glycation End-Products (AGEs) and Their Soluble Receptor (sRAGE) in Women Suffering from Systemic Lupus Erythematosus (SLE) [PDF]
Cells, 2021 Systemic lupus erythematosus (SLE) is characterized by abnormal action of the immune system and a state of chronic inflammation. The disease can cause life-threatening complications.
Agnieszka Nowak +5 more
doaj +2 more sources
Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury. [PDF]
Exp Mol Med, 2021 Advanced glycation end products (AGEs) are potentially harmful and heterogeneous molecules derived from nonenzymatic glycation. The pathological implications of AGEs are ascribed to their ability to promote oxidative stress, inflammation, and apoptosis ...
Rungratanawanich W +4 more
europepmc +2 more sources
Antioxidant and Antiglycation Effects of Polyphenol Compounds Extracted from Hazelnut Skin on Advanced Glycation End-Products (AGEs) Formation. [PDF]
Antioxidants (Basel), 2021 The advanced glycation end-products (AGEs) arise from non-enzymatic reactions of sugar with protein side chains, some of which are oxido-reductive in nature.
Spagnuolo L +4 more
europepmc +2 more sources
Advanced Glycation End Products (Ages) in Food: Focusing on Mediterranean Pasta [PDF]
Journal of Nutrition & Food Sciences, 2015 5Advanced glycation end products, also known as glycotoxins, are a diverse group of highly oxidant compounds with pathogenic significance in aged-chronic disease, including diabetes, cardiovascular disease and neurodegenerative disease. They are produced
Giulia Abate, Andrea Delbarba
core +6 more sources