Results 41 to 50 of about 42,960 (301)

The galectin-3/RAGE dyad modulates vascular osteogenesis in atherosclerosis [PDF]

, 2013
Vascular calcification correlates with inflammation and plaque instability in a dual manner, depending on the spotty/granular (micro) or sheet-like/lamellated (macro) pattern of calcification.
BLASETTI FANTAUZZI, Claudia, Carlo M., Pesce, Familiari, Giuseppe, Iacobini, Carla, Menini, Stefano, Pugliese, Giuseppe, Relucenti, Michela, Ricci, Carlo, Salvi, Laura, Taurino, Maurizio   +9 more
core   +1 more source

Advanced glycation end products (AGEs) activate mast cells [PDF]

British Journal of Pharmacology, 2010
BACKGROUND AND PURPOSEAdvanced glycation endproducts (AGEs) represent one of the many types of chemical modifications that occur with age in long‐lived proteins. AGEs also accumulate in pathologies such as diabetes, cardiovascular diseases, neurodegeneration and cancer. Mast cells are major effectors of acute inflammatory responses that also contribute
E, Sick, S, Brehin, P, André, G, Coupin, Y, Landry, K, Takeda, J P, Gies   +6 more
openaire   +2 more sources

Chemical Metabolomics: Chemical Biology Tools for Advanced Metabolism Investigations

Angewandte Chemie, EarlyView.
The human metabolism has been investigated for several millennia. The metabolome is known for a high complexity due to a large number of different metabolites that are present at different concentrations. Metabolomics has been developed as a field to investigate the entire human metabolome and to elucidate disease development mechanisms.
Alejandro Torregrosa‐Chinillach, Ioanna Tsiara, Wawrzyniec Haberek, Weifeng Lin, Daniel Globisch   +4 more
wiley   +2 more sources

Advanced glycation end products and their receptor contribute to ovarian ageing [PDF]

Human Reproduction, 2013
Do advanced glycation end products (AGE) and the receptor for advanced glycation end products (RAGE) affect the cells of the human ovarian follicle?AGE accumulate on the surface of ovarian granulosa-lutein (GL) cells and monocytes by binding to RAGE and other receptors with possible functional effects on these cells.AGE and RAGE are expressed in ...
Mette Haug, Stensen, Tom, Tanbo, Ritsa, Storeng, Peter, Fedorcsak   +3 more
openaire   +2 more sources

Pinocembrin Protects from AGE-Induced Cytotoxicity and Inhibits Non-Enzymatic Glycation in Human Insulin

Cells, 2019
Advanced glycation end products (AGEs) are the end products of the glycation reaction and have a great importance in clinical science for their association with oxidative stress and inflammation, which play a major role in most chronic diseases, such as ...
Margherita Borriello, Clara Iannuzzi, Ivana Sirangelo   +2 more
doaj   +1 more source

Recent Advances and the Potential for Clinical Use of Autofluorescence Detection of Extra-Ophthalmic Tissues [PDF]

, 2020
The autofluorescence (AF) characteristics of endogenous fluorophores allow the label-free assessment and visualization of cells and tissues of the human body.
Aigner, Felix, Pratschke, Johann, Schumann, Teresa, Stockmann, Martin, Tacke, Frank, Theil, Donna, Wizenty, Jonas, Wuensch, Tilo   +7 more
core   +1 more source

Glycation at the Crossroads of Disease Pathogenesis: Mechanistic Insights and Therapeutic Frontiers

Diseases
Protein glycation is a nonenzymatic modification that links sugar chemistry to molecular aging and chronic disease. Sequential reactions involving Schiff bases, Amadori products, and reactive α dicarbonyl intermediates generate advanced glycation end ...
Sneha Krishnamoorthi, Rupachandra Saravanakumar, Vivek Kumar   +2 more
doaj   +1 more source

Oxidative stress, protein glycation and nutrition – interactions relevant to health and disease throughout the lifecycle [PDF]

, 2014
Protein glycation has been studied for over a century now and plays an important role in disease pathogenesis throughout the lifecycle. Strongly related to diabetic complications, glycation of Hb has become the gold standard method for diabetes diagnosis
American Diabetes, Antonis Vlassopoulos, Bhagwat, El-Salem, Emilie Combet, Hao, Hodge, Khaw, Koenig, Maillard, Malickova, Michael E. J. Lean, Monnier, Nicholl, Rothwell, Schmidt, Sell, Vlassara   +17 more
core   +3 more sources

Advanced Glycation End Products in Age-related Macular Degeneration [PDF]

Archives of Ophthalmology, 1998
To investigate the localization of N epsilon-(carboxymethyl)lysine (CML), a component and major immunologic epitope of advanced glycation end products, in aged eyes and choroidal neovascular membranes (CNVMs) surgically excised from eyes with age-related macular degeneration.Immunohistochemistry for CML was performed using 8 snap-frozen, surgically ...
T, Ishibashi, T, Murata, M, Hangai, R, Nagai, S, Horiuchi, P F, Lopez, D R, Hinton, S J, Ryan   +7 more
openaire   +2 more sources

Inhibitory Effect of Tectoridin on the Formation of Advanced Glycation End Products

Shipin gongye ke-ji
It is of great significance to search for advanced glycation end products (AGEs) inhibitors with high activity and low side effects from food-borne natural products for the prevention and improvement of related diseases.
Fangyu GUO, Nanhai ZHANG, Qingru ZOU, Guanghui LI, Qingling PING, Yuan CHEN, Tao JIANG   +6 more
doaj   +1 more source