Results 41 to 50 of about 24,686 (257)

Oxygen Vacancy‐Enriched Platinum Single‐Atom Nanozyme Wrapped in Nanoislands: Unlocking Catalytic Activity and Reprogramming Redox Microenvironment for Osteonecrosis Repair

Advanced Science, EarlyView.
CeO2‐x/Pt single‐atom nano‐island is constructed via low‐temperature reduction, featuring abundant oxygen vacancies and an island–sea structure. It delivers outstanding multi‐enzyme‐mimetic activity and ROS‐scavenging efficiency. Density functional theory reveals optimized electronic structures and reaction pathways.
Yang Zhu, Zehui Lv, Xuejie Cai, Penghui Wei, Dengliang Wang, Zhao Wang, Ruoying Wang, Yingjie Wang, Xingdong Yang, Yixin Bian, Jiawei Xu, Xisheng Weng, Liangfeng Wei   +12 more
wiley   +1 more source

From Fork to Brain: The Role of AGE–RAGE Signaling and the Western Diet in Neurodegenerative Disease

NeuroSci
Advanced glycation end products (AGEs) are reactive compounds formed through non-enzymatic glycation in a process known as the Maillard reaction. While humans produce AGEs endogenously, these compounds can also enter the body through dietary sources ...
Haylie J. Pomroy, Arjun Mote, Simeon Mathew, Stebin Chanasseril, Victor Lu, Amanpreet K. Cheema   +5 more
doaj   +1 more source

NMI Regulates Adipose Adaptive Thermogenesis Through TLR4/IRF3 Signaling to Promote Obesity

Advanced Science, EarlyView.
Adipose tissue‐derived NMI is secreted under metabolic stress and suppresses adaptive thermogenesis through TLR4/IRF3 signaling, repressing the PPARα/PGC‐1α/UCP1 thermogenic transcriptional program. Genetic ablation or anti ‐ NMI monoclonal antibody treatment enhances energy expenditure, protects against DIO, and ameliorates adipose tissue inflammation,
Ting‐Ting Li, Xin‐Yuan Zhao, Min Zhang, Zhuang‐Feng Weng, Xiao‐Ran Guo, Ying‐Fang Liu, Qiao‐Ping Wang, Huan‐Huan Liang   +7 more
wiley   +1 more source

Fluorescent serum and urinary advanced glycoxidation end-products in non- diabetic subjects

Biological Research, 2007
Introduction: Advanced glycoxidation end-products (AGEs) are involved in age-related conditions and diabetic complications. Diet intake contributes to their circulating concentrations. Aim: To measure serum and urinary AGEs in non-diabetic volunteers and
MP DE LA MAZA, A BRAVO, L LEIVA, V GATTÁS, M PETERMANN, F GARRIDO, D BUNOUT, S HIRSCH, G BARRERA, M FERNÁNDEZ   +9 more
doaj  

The impact of advanced glycation end products and their receptors on the development and prognosis of colorectal cancer

BMC Cancer
Purpose The purpose of this study was to analyze whether advanced glycation end products (AGEs) and their receptors had an impact on the development and prognosis of colorectal cancer (CRC).
Li-Juan Wang, Xiao-Yu Liu, Can Tan, Zi-wei Wang, Yong Cheng   +4 more
doaj   +1 more source

The effect of Galega officinalis L. extract on the content of the advanced glycation end products and their receptors in rat leukocytes under experimental diabetes mellitus

Біологічні студії, 2021
Background. Diabetes mellitus intensifies non-enzymatic glycosylation (glycation) of biomolecules under conditions of chronic hyperglycemia and facilitates accumulation of advanced glycation end products.
Kh. Ye. Furtak, H. Ya. Hachkova, N. O. Sybirna   +2 more
doaj   +1 more source

A Plant Photoregulator‐Inspired S‐Type Heterojunction System for Diabetic Keratopathy via Tri‐Modal Light‐Driven Immunometabolic Reprogramming, Tissue Repair, and Antibacterial Activity

Advanced Science, EarlyView.
To address the multifaceted imbalance in diabetic keratopathy, a light‐responsive biomimetic platform (WCNx‐Rh2) is developed and integrates glucose degradation, immune modulation, and antibacterial defense through a designed heterojunction and screened immunomodulator. WCNx‐Rh2 reduces AGEs/ROS and inflammatory signaling, reprogramming dendritic cells
Mengzhen Zhao, Zhibin Zhou, Yuxuan Wei, Xiangfan Huang, Zhiyong Zhou, Jiaheng Chen, Haoxin Cheng, Xiaotian Hu, Xiaolei Wang   +8 more
wiley   +1 more source

Role of polyphenols in modulating AGEs-RAGE axis in cancer, a review

Bulletin of the National Research Centre
Background and purpose The glycation process produces a great deal of free radicals during its initial and propagation phases. It also produces carbonyl species and reactive dicarbonyl species, the most reactive of which is methylglyoxal (MG), which may ...
Ritu Raina, P. S. K. Sanjana, Saleha Mohammed Razaulla, Ravinder Bhatt, Arif Hussain   +4 more
doaj   +1 more source

Dietary Phenolics as Reactive Carbonyl Scavengers: Potential Impact on Human Health and Mechanism of Action

Journal of Traditional and Complementary Medicine, 2013
Previous studies have demonstrated that accumulation of reactive carbonyl compounds in human tissue will accelerate the vascular damage in both diabetes and uremia. Moreover, advanced glycation progressively and irreversibly modify the proteins over time
Chi-Tang Ho, Mingfu Wang
doaj   +1 more source

S100A8/A9‐High Macrophages Activate Intestinal Fibroblasts via mCCL6/hCCL15‐CCR1 Axis to Drive Intestinal Fibrosis in Crohn's Disease

Advanced Science, EarlyView.
S100A8/A9‐high macrophages are markedly enriched in the stenotic intestinal tissue of patients with Crohn's disease. These profibrotic macrophages secrete mCCL6 in a STAT3‐dependent manner. mCCL6 and its human ortholog hCCL15 activate fibroblasts via the CCR1 receptor, thereby driving excessive collagen deposition.
Shu Wang, Jiayun Wang, Junjie Lin, Ziping Ye, Geyujia Zhou, Jingjing Ma, Junjian Sun, Jiang Yu, Yingdi Zhang, Nana Tang, Chunhua Jiao, Xiaojing Zhao, Hongjie Zhang   +12 more
wiley   +1 more source