Results 51 to 60 of about 8,796,374 (289)

Inhibitory effects of Blackstonia grandiflora extracts on the formation of advanced glycation end products (AGEs) [PDF]

, 2016
Glycation, the nonenzymatic reaction of reducing sugars with amino groups, is increased in hyperglycemic physiological environments, leading to an acceleration of the formation of advanced glycation end products (AGEs).
F.Z. Belfadel, S. Akkal, S. Derbré, Derbré, Séverine, Akkal, Salah, Medjroubi, Kamel, Seguin, Elisabeth, K. Medjroubi, E. Seguin, Belfadel, Fatima Zohra   +9 more
core   +2 more sources

Inhibitory Effect of Tectoridin on the Formation of Advanced Glycation End Products

Shipin gongye ke-ji
It is of great significance to search for advanced glycation end products (AGEs) inhibitors with high activity and low side effects from food-borne natural products for the prevention and improvement of related diseases.
Fangyu GUO, Nanhai ZHANG, Qingru ZOU, Guanghui LI, Qingling PING, Yuan CHEN, Tao JIANG   +6 more
doaj   +1 more source

Advanced glycation end products and their receptor contribute to ovarian ageing [PDF]

Human Reproduction, 2013
Do advanced glycation end products (AGE) and the receptor for advanced glycation end products (RAGE) affect the cells of the human ovarian follicle?AGE accumulate on the surface of ovarian granulosa-lutein (GL) cells and monocytes by binding to RAGE and other receptors with possible functional effects on these cells.AGE and RAGE are expressed in ...
Mette Haug, Stensen, Tom, Tanbo, Ritsa, Storeng, Peter, Fedorcsak   +3 more
openaire   +2 more sources

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

Assessment of Oral Glycine and Lysine Therapy on Receptor for Advanced Glycation End Products and Transforming Growth Factor Beta Expression in the Kidney of Streptozotocin-Induced Diabetic Rats in Comparison with Normal Rats [PDF]

Journal of Kerman University of Medical Sciences, 2014
Background & Aims: Today, diabetic nephropathy is considered to be one of the most common causes of end stage renal disease. Uncontrolled hyperglycemia, and consequently, production of advanced glycation end products activate pathways which play key ...
Somayeh Sadat Heidary, Sayedeh Zahra Bathaie, Fereshteh Bahmani, Gholamreza Moshtaghi Kashanian   +3 more
doaj  

A Plant Photoregulator‐Inspired S‐Type Heterojunction System for Diabetic Keratopathy via Tri‐Modal Light‐Driven Immunometabolic Reprogramming, Tissue Repair, and Antibacterial Activity

Advanced Science, EarlyView.
To address the multifaceted imbalance in diabetic keratopathy, a light‐responsive biomimetic platform (WCNx‐Rh2) is developed and integrates glucose degradation, immune modulation, and antibacterial defense through a designed heterojunction and screened immunomodulator. WCNx‐Rh2 reduces AGEs/ROS and inflammatory signaling, reprogramming dendritic cells
Mengzhen Zhao, Zhibin Zhou, Yuxuan Wei, Xiangfan Huang, Zhiyong Zhou, Jiaheng Chen, Haoxin Cheng, Xiaotian Hu, Xiaolei Wang   +8 more
wiley   +1 more source

S100A8/A9‐High Macrophages Activate Intestinal Fibroblasts via mCCL6/hCCL15‐CCR1 Axis to Drive Intestinal Fibrosis in Crohn's Disease

Advanced Science, EarlyView.
S100A8/A9‐high macrophages are markedly enriched in the stenotic intestinal tissue of patients with Crohn's disease. These profibrotic macrophages secrete mCCL6 in a STAT3‐dependent manner. mCCL6 and its human ortholog hCCL15 activate fibroblasts via the CCR1 receptor, thereby driving excessive collagen deposition.
Shu Wang, Jiayun Wang, Junjie Lin, Ziping Ye, Geyujia Zhou, Jingjing Ma, Junjian Sun, Jiang Yu, Yingdi Zhang, Nana Tang, Chunhua Jiao, Xiaojing Zhao, Hongjie Zhang   +12 more
wiley   +1 more source

Advanced glycation end products and risk of mortality in patients with cirrhosis: a prospective cohort study

Scientific Reports
The role of diet in reducing the burden of liver disease and mortality attributed to cirrhosis is very imperative. The present study scrutinized the relationship between dietary advanced glycation end products (AGEs) and mortality in patients with ...
Mohsen Shaygan Tabar, Maryam Nilghaz, Azita Hekmatdoost, Fereshteh Pashayee-Khamene, Zeinab Mokhtari, Sara Karimi, Saleheh Ahmadzadeh, Mehdi Saberifiroozi, Behzad Hatami, Zahra Yari   +9 more
doaj   +1 more source

In Situ Profiling of Nanoscale Strains Uncovers Mechano‐Architectural Predictors of Aging and Osteoarthritis Emergence

Advanced Science, EarlyView.
In situ mechanical loading of osteoarthritis‐prone murine knee joints reveals that spatial alterations in subchondral plate microarchitecture precede cartilage loss and promote a shift from coordinated epiphyseal strain dissipation in healthy joints to focal subchondral strain concentration in osteoarthritis‐prone joints.
Aikta Sharma, Lucinda A. E. Evans, Lucie E. Bourne, Jishizhan Chen, Alissa L. Parmenter, Joseph Brunet, Kamel Madi, Sebastian Marussi, Andrew A. Pitsillides, Peter D. Lee, Katherine A. Staines   +10 more
wiley   +1 more source

The role of AGEs in skeletal muscle atrophy and the beneficial effects of exercise

Frontiers in Medicine
BackgroundAdvanced Glycation End Products (AGEs) are associated with the aging and atrophy of skeletal muscle. Their pathogenic mechanism mainly involves the binding of AGEs to their own receptors, which in turn triggers a series of pathological ...
Xinru Wu, Xinru Wu, Shuai Hu, Shuai Hu, Wei Miao, Fei Shen, Fei Shen, Li Jiang   +7 more
doaj   +1 more source