Results 61 to 70 of about 8,796,374 (289)

ANGPTL4 Exacerbates Renal Injury in Diabetic Kidney Disease by Impairing Podocyte Lipophagy via Compromised Lysosomal Degradative Function

Advanced Science, EarlyView.
In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu, Shimin Jiang, Zhenkun Yang, Shunlai Shang, Jiayi Li, Guming Zou, Cheng Zhou, Wenge Li   +7 more
wiley   +1 more source

From Fork to Brain: The Role of AGE–RAGE Signaling and the Western Diet in Neurodegenerative Disease

NeuroSci
Advanced glycation end products (AGEs) are reactive compounds formed through non-enzymatic glycation in a process known as the Maillard reaction. While humans produce AGEs endogenously, these compounds can also enter the body through dietary sources ...
Haylie J. Pomroy, Arjun Mote, Simeon Mathew, Stebin Chanasseril, Victor Lu, Amanpreet K. Cheema   +5 more
doaj   +1 more source

Pharmacologic approaches against Advanced Glycation End Products (AGEs) in diabetic cardiovascular disease

Research in Cardiovascular Medicine, 2015
Context: Advanced Glycation End-Products (AGEs) are signaling proteins associated to several vascular and neurological complications in diabetic and non-diabetic patients.
Antonio Nenna, Francesco Nappi, Sanjeet Singh Avtaar Singh, Fraser W Sutherland, Fabio Di Domenico, Massimo Chello, Cristiano Spadaccio   +6 more
doaj   +1 more source

The effect of Galega officinalis L. extract on the content of the advanced glycation end products and their receptors in rat leukocytes under experimental diabetes mellitus

Біологічні студії, 2021
Background. Diabetes mellitus intensifies non-enzymatic glycosylation (glycation) of biomolecules under conditions of chronic hyperglycemia and facilitates accumulation of advanced glycation end products.
Kh. Ye. Furtak, H. Ya. Hachkova, N. O. Sybirna   +2 more
doaj   +1 more source

AGEs (Advanced Glycation End-products) in bone come of age

Bone
Advanced Glycation End-products (AGEs) are seen in long-lived proteins and were not expected to accumulate in the bone that turnovers and renews itself. Here, we provide a commentary on the contrary, highlighting the Special Issue of AGEs in Bone. An outcome of hyperglycemia and increased oxidative stress, AGEs form and accumulate by altering the bone ...
Vashishth, Deepak, Dhaliwal, Ruban, Rubin, Mishaela   +2 more
openaire   +3 more sources

Metabolic Memory in Cardiovascular Disease: Encoding, Propagation, and Therapeutic Targeting

Advanced Science, EarlyView.
Cardiovascular risk often persists after metabolic abnormalities are corrected. This conceptual Review frames such persistence as metabolic memory, encoded through a narrowing therapeutic window from reversible marks to irreversible damage, with continuous input from peripheral organs.
Cheng Cheng, Minghui Tang, Zhaobo Zhang, Ruoyi Qu, Jianfei Pei, Tian Liu, Siyao Qu, Shilong You, Shenshen Cui, Wenke Wang, Rui Zhao, Yingxian Sun, Naijin Zhang   +12 more
wiley   +1 more source

The impact of advanced glycation end products and their receptors on the development and prognosis of colorectal cancer

BMC Cancer
Purpose The purpose of this study was to analyze whether advanced glycation end products (AGEs) and their receptors had an impact on the development and prognosis of colorectal cancer (CRC).
Li-Juan Wang, Xiao-Yu Liu, Can Tan, Zi-wei Wang, Yong Cheng   +4 more
doaj   +1 more source

Skin autofluorescence in diabetes mellitus [PDF]

, 2008
AGEs ofwel advanced glycation endproducts zijn onomkeerbaar versuikerde stoffen, die voornamelijk aan eiwitten zijn gekoppeld, en die bij ieder mens stapelen. Bij iemand met diabetes mellitus gaat dit proces echter versneld.
Lutgers, Helen Lucia, Lutgers, H.L.,, Lutgers, H.L.   +2 more
core   +14 more sources

Advanced glycation end-products induce skeletal muscle atrophy and dysfunction in diabetic mice via a RAGE-mediated, AMPK-down-regulated, Akt pathway

, 2017
Diabetic myopathy, a less studied complication of diabetes, exhibits the clinical observations characterized by a less muscle mass, muscle weakness and a reduced physical functional capacity.
蔡克嵩;楊庭華;詹鼎正;劉興華;姜至剛;楊榮森, Chiu, Chen-Yuan;Yang, Rong-Sen;Sheu, Meei-Ling;Chan, Ding-Cheng;Yang, Ting-Hua;Tsai, Keh-Sung;Chiang, Chih-Kang;Liu, Shing-Hwa   +1 more
core   +1 more source

Modulation of soluble receptor for advanced glycation end products isoforms and advanced glycation end products in long-living individuals

, 2021
Background: Circulating levels of soluble receptor for advanced glycation end products (sRAGE) and advanced glycation end products (AGEs) correlate with aging/cardiovascular risk, which is delayed in long-living individuals (LLIs).
Scavello F., Raucci A., Castiglione S., MacIag A., Spinetti G., Tedesco C. C., Veglia F., Puca A. A., Sangalli E.   +8 more
core   +1 more source