Differential effects of glyoxalase 1 overexpression on diabetic atherosclerosis and renal dysfunction in streptozotocin-treated, apolipoprotein E-deficient mice [PDF]
, 2014 The reactive dicarbonyls, glyoxal and methylglyoxal (MG), increase in diabetes and may participate in the development of diabetic complications. Glyoxal and MG are detoxified by the sequential activities of glyoxalase 1 (GLO1) and glyoxalase 2.
Rabbani, Naila +11 more
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The Possible Mechanism of Advanced Glycation End Products (AGEs) for Alzheimer's Disease. [PDF]
PLoS ONE, 2015 Amyloid precursor protein (APP) has been modified by β and γ-secretase that cause amyloid deposits (plaques) in neuronal cells. Glyceraldhyde-derived AGEs has been identified as a major source of neurotoxicity in Alzheimer's disease (AD).
Shun-Yao Ko +7 more
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Aging ovary and the role for advanced glycation end products
Menopause, 2017 Abstract Objective: The hypothalamic gonadotropin-releasing hormone pulse generator, the pituitary gonadotropes, the ovaries, and the uterus play a crucial role in female fertility. A decline in reproductive performance represents a complex interplay of actions at all levels of the hypothalamic-pituitary-ovarian axis.
Pertynska-Marczewska, Magdalena +1 more
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Protein glycoxidation in neuropsychiatric disorders—from basic research to clinical practice
Redox BiologyThis review integrates current findings on protein glycation, glycoxidation, and carbonyl stress in selected neurodegenerative and neuropsychiatric disorders, with a particular focus on mechanistic pathways relevant to Alzheimer's disease (AD), Parkinson'
Wiktor Orlof, Mateusz Maciejczyk
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AKTIVITAS ANTIFOTOOKSIDASI DAN PENGHAMBAT PEMBENTUKAN AGES (ADVANCED GLYCATION END-PRODUCTS) DARI FRAKSI ALGA Padina australis [PDF]
, 2018 AKTIVITAS ANTIFOTOOKSIDASI DAN PENGHAMBAT PEMBENTUKAN AGES (ADVANCED GLYCATION END-PRODUCTS) DARI FRAKSI ALGA Padina australisSyutria Trifosa Kondoj1), Edi Suryanto2), Max Runtuwene2)1)Program Studi Farmasi FMIPA Unsrat Manado, 951152)Jurusan Kimia FMIPA
Kondoj, Syutria T.
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Medicina, 2023 Background and Objectives: Gluten-free products have been produced as part of medical therapy and have gained popularity among individuals seeking weight loss or healthier dietary options.
Yeliz Serin +2 more
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Advanced glycation end products
, 2022 Advanced glycation end products (AGEs) are a heterogeneous group of compounds formed by non-enzymatic interactions between the carbonyl groups of reducing sugars and free amino groups of proteins, lipids, or nucleic acids.
Dat, Pham Thai
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HMGB-1 - a novel mediator of inflammatory-induced renal epithelial mesenchymal transition [PDF]
, 2010 Background: High mobility group box protein 1 (HMGB-1) is a chromatin binding protein that bends DNA thereby facilitating gene transcription. HMGB-1 has also been observed as an extracellular secreted protein in serum of patients with sepsis and has ...
Ryan, Michael P. +11 more
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Histone functions as a cell-surface receptor for AGEs
Nature Communications, 2022 Advanced glycation end products (AGEs) are believed to be pathogenic molecules that mediate pro-inflammatory responses. Here the authors identify histone as a cell-surface receptor for AGEs and show that AGEs may also be involved in the homeostatic ...
Masanori Itakura +10 more
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Advanced glycation end products (AGEs) activate mast cells [PDF]
British Journal of Pharmacology, 2010 BACKGROUND AND PURPOSEAdvanced glycation endproducts (AGEs) represent one of the many types of chemical modifications that occur with age in long‐lived proteins. AGEs also accumulate in pathologies such as diabetes, cardiovascular diseases, neurodegeneration and cancer. Mast cells are major effectors of acute inflammatory responses that also contribute
Sick, E. +6 more
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