Results 21 to 30 of about 24,686 (257)

Advanced glycation end products (AGEs) activate mast cells [PDF]

British Journal of Pharmacology, 2010
BACKGROUND AND PURPOSEAdvanced glycation endproducts (AGEs) represent one of the many types of chemical modifications that occur with age in long‐lived proteins. AGEs also accumulate in pathologies such as diabetes, cardiovascular diseases, neurodegeneration and cancer. Mast cells are major effectors of acute inflammatory responses that also contribute
E, Sick, S, Brehin, P, André, G, Coupin, Y, Landry, K, Takeda, J P, Gies   +6 more
openaire   +2 more sources

How Can Diet Affect the Accumulation of Advanced Glycation End-Products in the Human Body?

Foods, 2016
The accumulation of advanced glycation end products (AGEs) is associated with the complications of diabetes, kidney disease, metabolic disorders and degenerative diseases. It is recognized that the pool of glycation products found in the human body comes
Axel Guilbaud, Celine Niquet-Leridon, Eric Boulanger, Frederic J. Tessier   +3 more
doaj   +1 more source

Histone functions as a cell-surface receptor for AGEs

Nature Communications, 2022
Advanced glycation end products (AGEs) are believed to be pathogenic molecules that mediate pro-inflammatory responses. Here the authors identify histone as a cell-surface receptor for AGEs and show that AGEs may also be involved in the homeostatic ...
Masanori Itakura, Kosuke Yamaguchi, Roma Kitazawa, Sei-Young Lim, Yusuke Anan, Jun Yoshitake, Takahiro Shibata, Lumi Negishi, Hikari Sugawa, Ryoji Nagai, Koji Uchida   +10 more
doaj   +1 more source

Investigating Bioaccessibility of Advanced Glycation Product Precursors in Gluten-Free Foods Using In Vitro Gastrointestinal System

Medicina, 2023
Background and Objectives: Gluten-free products have been produced as part of medical therapy and have gained popularity among individuals seeking weight loss or healthier dietary options.
Yeliz Serin, Gamze Akbulut, Mustafa Yaman   +2 more
doaj   +1 more source

Enrichment and analysis of glycated proteins

Reviews in Analytical Chemistry, 2022
Glycation is a spontaneous post-translational modification of lysine, arginine, and the N-terminus of proteins. Protein glycation is closely related to the pathogenesis of human diseases, including diabetes, Alzheimer’s disease, renal disease, and cancer.
Cho Seonghyeon, Duong Van-An, Mok Jeong-Hun, Joo Minjoong, Park Jong-Moon, Lee Hookeun   +5 more
doaj   +1 more source

Advanced glycation end products and their receptor contribute to ovarian ageing [PDF]

Human Reproduction, 2013
Do advanced glycation end products (AGE) and the receptor for advanced glycation end products (RAGE) affect the cells of the human ovarian follicle?AGE accumulate on the surface of ovarian granulosa-lutein (GL) cells and monocytes by binding to RAGE and other receptors with possible functional effects on these cells.AGE and RAGE are expressed in ...
Mette Haug, Stensen, Tom, Tanbo, Ritsa, Storeng, Peter, Fedorcsak   +3 more
openaire   +2 more sources

Antiglycation potential of commercial available extracts of two Indian medicinal plants: Pterocarpus marsupium and Artocarpus lakoocha using advanced glycation end products (AGE) competitive fluorescence assay

Cogent Food & Agriculture, 2021
Glycation is a non-enzymatic biochemical reaction between reducing sugars and amino acids, causing the crosslinking and rearrangement of glycated proteins, leading to irreversible formation of Advanced Glycation End products (AGEs).
Alpana Pande, Lakshmi Mundkur, Anurag Pande, Sarang Bani, Muhammed Majeed   +4 more
doaj   +1 more source

Glycation at the Crossroads of Disease Pathogenesis: Mechanistic Insights and Therapeutic Frontiers

Diseases
Protein glycation is a nonenzymatic modification that links sugar chemistry to molecular aging and chronic disease. Sequential reactions involving Schiff bases, Amadori products, and reactive α dicarbonyl intermediates generate advanced glycation end ...
Sneha Krishnamoorthi, Rupachandra Saravanakumar, Vivek Kumar   +2 more
doaj   +1 more source

Pinocembrin Protects from AGE-Induced Cytotoxicity and Inhibits Non-Enzymatic Glycation in Human Insulin

Cells, 2019
Advanced glycation end products (AGEs) are the end products of the glycation reaction and have a great importance in clinical science for their association with oxidative stress and inflammation, which play a major role in most chronic diseases, such as ...
Margherita Borriello, Clara Iannuzzi, Ivana Sirangelo   +2 more
doaj   +1 more source

Advanced Glycation End Products in Age-related Macular Degeneration [PDF]

Archives of Ophthalmology, 1998
To investigate the localization of N epsilon-(carboxymethyl)lysine (CML), a component and major immunologic epitope of advanced glycation end products, in aged eyes and choroidal neovascular membranes (CNVMs) surgically excised from eyes with age-related macular degeneration.Immunohistochemistry for CML was performed using 8 snap-frozen, surgically ...
T, Ishibashi, T, Murata, M, Hangai, R, Nagai, S, Horiuchi, P F, Lopez, D R, Hinton, S J, Ryan   +7 more
openaire   +2 more sources