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The intake of advanced glycation end products and inflammation in aging
European Geriatric Medicine, 2012Introduction. With aging, the levels of circulating inflammatory mediators tend to increase. As Advanced Glycation End products (AGE's) are known to have pro-inflammatory effects, we hypothesized that the dietary intake of AGE's might contribute to the inflammatory status in old age. Methods.
Van Puyvelde, Katrien +6 more
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Advanced Glycation End Products (AGEs)
2019Glycation refers to the addition of a sugar moiety to a protein molecule and occurs during the Maillard reaction. Maillard reaction is initiated by the condensation of amino groups of proteins, peptides, and amino acids with carbonyl groups of reducing sugars.
Akıllıoğlu, Halise Gül +1 more
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Advanced Glycation End Products and Bone Loss during Aging
Annals of the New York Academy of Sciences, 2005Abstract: It is well known that bone mass density decreases with age. Age‐related bone mass loss is ascribed to several factors. Nonenzymatic glycation has been proposed as a new potential factor in the loss of bone during aging. In this study we evaluated the concentration of pentosidine, an advanced glycation end product, in cortical and trabecular ...
ODETTI, PATRIZIO +6 more
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Bone Aging by Advanced Glycation End Products
Journal of Dental Research, 2015The quality and quantity of mandibular bone are essential prerequisites for osseointegrated implants. Only the Hounsfield unit on preoperative computed tomography is currently used as a clinical index. Nevertheless, a considerable mismatch occurs between bone quality and the Hounsfield unit.
K, Ganeko +7 more
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Advanced glycation end-products (AGEs): involvement in aging and in neurodegenerative diseases
Amino Acids, 2007Advanced glycation end-products (AGEs) are formed from the so-called Amadori products by rearrangement followed by other reactions giving rise to compounds bound irreversibly. The structure of some of them is shown and the mechanism of formation is described.
M.A. GRILLO, COLOMBATTO, Sebastiano
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Advanced Glycation End Products (AGEs) and their Involvement in Liver Disease
Current Pharmaceutical Design, 2008Advanced glycation end products (AGEs) are a heterogeneous group of molecules, formed in vivo both by non-oxidative and oxidative reactions of sugars and their adducts to proteins and lipids. It is now well established that formation and accumulation of AGEs progress during normal aging, and at an extremely accelerated rate under diabetes, thus being ...
Hideyuki, Hyogo, Sho-ichi, Yamagishi
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Advanced Glycation End Products of the Maillard Reaction and Their Relation to Aging
Gerontology, 2009Long-term incubation of proteins with glucose leads to advanced glycation end products (AGE). Demonstration of AGE in vivo as well as determination of its main structure are crucial to elucidate its potential link to aging processes and diabetic complications.
S, Horiuchi, N, Araki
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Inhibitors of Advanced Glycation End Product (AGE) Formation and Accumulation
2020A range of chemically different compounds are known to inhibit the formation and accumulation of advanced glycation end products (AGEs) or disrupt associated signalling pathways. There is evidence that some of these agents can provide end-organ protection in chronic diseases including diabetes.
Karly C, Sourris +2 more
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Advanced Glycation End Products, RAGE, and Aging
2010The products of nonenzymatic glycation and oxidation of proteins and lipids, the advanced glycation end products (AGEs), accumulate in diverse biological settings including aging. AGEs may be generated rather quickly or over long duration as a consequence of distinct triggering mechanisms, thereby accounting for their roles in multiple settings and ...
Ravichandran Ramasamy +3 more
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Advanced Glycation End Products (AGEs) and Diabetic Vascular Complications
Current Diabetes Reviews, 2005Diabetic vascular complication is a leading cause of acquired blindness, end-stage renal failure, a variety of neuropathies and accelerated atherosclerosis, which could account for disabilities and high mortality rates in patients with diabetes. Chronic hyperglycemia is essentially involved in the development and progression of diabetic micro- and ...
Sho-ichi, Yamagishi +2 more
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