Bone canonical Wnt signaling is downregulated in type 2 diabetes and associates with higher advanced glycation end-products (AGEs) content and reduced bone strength. [PDF]
ElifeLeanza G +17 more
europepmc +3 more sources
A Role for Advanced Glycation End Products in Molecular Ageing
International Journal of Molecular Sciences, 2023 Ageing is a composite process that involves numerous changes at the cellular, tissue, organ and whole-body levels. These changes result in decreased functioning of the organism and the development of certain conditions, which ultimately lead to an increased risk of death.
Katarzyna Zgutka +3 more
openaire +2 more sources
Contribution of Glycation and Oxidative Stress to Thyroid Gland Pathology—A Pilot Study
Biomolecules, 2021 The patho-mechanism of changes in the thyroid gland, including carcinogenesis, is a complex process, which involves oxidative stress. The goal of our investigation was to verify the extent of stress in the thyroid gland related to glycation.
Aleksandra Kuzan +8 more
doaj +1 more source
Dietary Advanced Glycation End Products and Aging [PDF]
Nutrients, 2010 Advanced glycation end products (AGEs) are a heterogeneous, complex group of compounds that are formed when reducing sugar reacts in a non-enzymatic way with amino acids in proteins and other macromolecules. This occurs both exogenously (in food) and endogenously (in humans) with greater concentrations found in older adults.
Karen Chapman-Novakofski +1 more
openaire +3 more sources
Advanced Glycation End Products and Psoriasis
Vaccines, 2023 Advanced glycation end products (AGEs) are biologically active compounds formed physiologically throughout a sequence of chemical reactions, to generate highly oxidant-reactive aldehydes that combine covalently to proteins.
Martina Maurelli +2 more
doaj +1 more source
Clinical Factors and Biomarkers Associated with Depressive Disorders in Older Patients Affected by Chronic Kidney Disease (CKD): Does the Advanced Glycation End Products (AGEs)/RAGE (Receptor for AGEs) System Play Any Role? [PDF]
Geriatrics (Basel)Buoli M +7 more
europepmc +3 more sources
Advanced Glycation End Product Recognition by the Receptor for AGEs [PDF]
Structure, 2011 Nonenzymatic protein glycation results in the formation of advanced glycation end products (AGEs) that are implicated in the pathology of diabetes, chronic inflammation, Alzheimer's disease, and cancer. AGEs mediate their effects primarily through a receptor-dependent pathway in which AGEs bind to a specific cell surface associated receptor, the ...
David Singer +9 more
openaire +3 more sources
The Role of Dietary Advanced Glycation End Products (AGEs) in Metabolic Dysfunction.
Molecular Nutrition & Food Research, 2020 Advanced glycation end products (AGEs) are a heterogeneous group of molecules produced, non-enzymatically, from the interaction between reducing sugars and the free amino groups of proteins, nucleic acids and lipids.
D. Sergi +3 more
semanticscholar +1 more source
Advanced glycation end products [PDF]
Dermato-Endocrinology, 2012 Aging is the progressive accumulation of damage to an organism over time leading to disease and death. Aging research has been very intensive in the last years aiming at characterizing the pathophysiology of aging and finding possibilities to fight age-related diseases. Various theories of aging have been proposed.
Markus Böhm, Paraskevi Gkogkolou
openaire +3 more sources
Do advanced glycation end products contribute to food allergy?
Frontiers in Allergy, 2023 Sugars can bind non-enzymatically to proteins, nucleic acids or lipids and form compounds called Advanced Glycation End Products (AGEs). Although AGEs can form in vivo, factors in the Western diet such as high amounts of added sugars, processing methods ...
P. K. Smith +4 more
doaj +1 more source