The Journal of Physiology, EarlyView.Abstract figure legend Benefits of performing physical exercise at moderate altitude. At moderate altitude, increased resting metabolic rate and physical exertion promote physical fitness and exercise tolerance, whereas hypoxia suppresses appetite and elicits adaptations that increase tissue O2 delivery while augmenting O2‐independent ATP production ...
Robert T. Mallet +6 more
wiley +1 more source
Metabolic reprogramming in colorectal cancer: a review of aerobic glycolysis and its therapeutic implications for targeted treatment strategies. [PDF]
Cell Death DiscovPang B, Wu H.
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Regulation of pyruvate dehydrogenase complex: Dancing to different drums in cancer
International Journal of Cancer, Volume 158, Issue 6, Page 1464-1480, 15 March 2026.Abstract Mechanisms governing the regulation of pyruvate dehydrogenase complex (PDC) are markedly modified in cancer cells compared to normal cells. PDC activity in normal cells is controlled by the reversible phosphorylation of three serine residues by dedicated kinases and phosphatases.
Mulchand S. Patel, Todd C. Rideout
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Lactate Dehydrogenase Inhibition Reverts the Fatty Acid‐Induced Neurotoxic Phenotype of Astrocytes
Glia, Volume 74, Issue 3, March 2026.ALS models display increased LD accumulation. LD accumulation is linked to a neurotoxic phenotype in astrocytes. Lactate dehydrogenase inhibition reverts LD accumulation in ALS astrocytes. ABSTRACT Astrocytes are central to lipid metabolism in the central nervous system.
Daniel Esteve +5 more
wiley +1 more source
Retraction Note: Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression. [PDF]
Nat CommunWeng ML +15 more
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International Journal of Cancer, Volume 158, Issue 5, Page 1156-1165, 1 March 2026.Abstract Tumor‐infiltrating B cells (TIBs) exhibit dual roles in the tumor microenvironment (TME) of solid tumors. While they can enhance anti‐tumor immunity through antibody production and immune activation, certain subsets—such as regulatory B cells (Bregs) and immunosuppressive plasma cells—contribute to immune evasion by secreting inhibitory ...
Zhitong Li +5 more
wiley +1 more source
Activation of sclerostin inhibits Isg20-Mediated aerobic glycolysis ameliorating renal Fibrosis: the renoprotective mechanism of hederagenin in CKD. [PDF]
Redox BiolHan RY +9 more
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JOR SPINE, Volume 9, Issue 1, March 2026.Goat nucleus pulposus cells cultured under clinically relevant oxygen, glucose, pH, and osmolarity revealed pH to have the most influential impact on viability and glycosaminoglycan synthesis. Interactions between factors showed that disc cell behavior is shaped by the microenvironment, highlighting its importance in regenerative therapy design for the
Niamh Wilson +5 more
wiley +1 more source
SMAD3 and HIF-1α orchestrate metabolic transition to aerobic glycolysis as a critical prerequisite for spontaneous reprogramming of spermatogonial stem cells. [PDF]
Stem Cell Res TherCai Y +7 more
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Targeting Tumor Dormancy and Recurrence: Molecular Mechanisms and Peptide Therapeutic Delivery
MedComm – Oncology, Volume 5, Issue 1, March 2026.This review summarizes the molecular mechanisms that regulate tumor dormancy and its role in cancer recurrence, with emphasis on immune evasion, extracellular matrix remodeling, metabolic regulation and angiogenic switching. It further discusses emerging peptide–based therapeutic strategies aimed at detecting, modulating, and eliminating dormant tumor ...
Abdur Raheem Aleem +9 more
wiley +1 more source