Results 101 to 110 of about 2,414,823 (352)

Engineered high-affinity zinc binding site reveals gating configurations of a human proton channel [PDF]

, 2020
Vladimir V. Cherny, Boris Musset, Deri Morgan, Sarah Thomas, Susan M. Smith, Thomas E. DeCoursey   +5 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

The effect of consumption of cranberry (Vaccinium macrocarpon) on Escherichia coli adherence to feline uroepithelial cells in a blind randomised cross-over trial in cats

Journal of Veterinary Research
Escherichia coli is the most common uropathogen in humans, dogs and cats. Dietary consumption of cranberry (Vaccinium macrocarpon) is known to be associated with a reduction in uropathogenic E.
Carvajal-Campos Amaranta, Trebossen Lucile, Jeusette Isabelle, Mayot Gilles, Torre Celina, Fragua Victor, Fernandez Anna, Martino Patrick Di   +7 more
doaj   +1 more source

Effects of Different Rootstocks Grafting Tomato on Enzyme Activity and Hormone Content

Guangdong nongye kexue
【Objective】The research aimed to study the affinity performance of solanaceous crops grafting, and explore the physiological and biochemical reactions at the interface of tomato scion grafted on different rootstocks.【Method】By setting tomato scion self ...
Wenyu MEI, Zhenxing LI, Xingpin CHEN, Chao GONG, Baojuan SUN, Weijie XU, Guo ZENG, Tao LI   +7 more
doaj   +1 more source

Identification, Characterization, and Optimization of Integrin αvβ6-Targeting Peptides from a One-Bead One-Compound (OBOC) Library: Towards the Development of Positron Emission Tomography (PET) Imaging Agents

Molecules, 2019
The current translation of peptides identified through the one-bead one-compound (OBOC) technology into positron emission tomography (PET) imaging agents is a slow process, with a major delay between ligand identification and subsequent lead optimization.
Yng (Sarah) C. Tang, Ryan A. Davis, Tanushree Ganguly, Julie L. Sutcliffe   +3 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Learning Combinatorial Embedding Networks for Deep Graph Matching

, 2019
Graph matching refers to finding node correspondence between graphs, such that the corresponding node and edge's affinity can be maximized. In addition with its NP-completeness nature, another important challenge is effective modeling of the node-wise ...
Wang, Runzhong, Yan, Junchi, Yang, Xiaokang   +2 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Fibrés affines

Michigan Mathematical Journal, 2001
26 pages, To be published in the Michigan Mathematical ...
openaire   +3 more sources