Results 101 to 110 of about 2,414,823 (352)
Engineered high-affinity zinc binding site reveals gating configurations of a human proton channel [PDF]
Vladimir V. Cherny +5 more
openalex +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Escherichia coli is the most common uropathogen in humans, dogs and cats. Dietary consumption of cranberry (Vaccinium macrocarpon) is known to be associated with a reduction in uropathogenic E.
Carvajal-Campos Amaranta +7 more
doaj +1 more source
Effects of Different Rootstocks Grafting Tomato on Enzyme Activity and Hormone Content
【Objective】The research aimed to study the affinity performance of solanaceous crops grafting, and explore the physiological and biochemical reactions at the interface of tomato scion grafted on different rootstocks.【Method】By setting tomato scion self ...
Wenyu MEI +7 more
doaj +1 more source
The current translation of peptides identified through the one-bead one-compound (OBOC) technology into positron emission tomography (PET) imaging agents is a slow process, with a major delay between ligand identification and subsequent lead optimization.
Yng (Sarah) C. Tang +3 more
doaj +1 more source
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Learning Combinatorial Embedding Networks for Deep Graph Matching
Graph matching refers to finding node correspondence between graphs, such that the corresponding node and edge's affinity can be maximized. In addition with its NP-completeness nature, another important challenge is effective modeling of the node-wise ...
Wang, Runzhong +2 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
26 pages, To be published in the Michigan Mathematical ...
openaire +3 more sources

