Results 141 to 150 of about 2,425,944 (351)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Periadventitial Delivery of Simvastatin from Microparticles Attenuates Arteriovenous Fistula Outflow Vein Neointimal Hyperplasia

JVS - Vascular Science, 2020
Chenglei Zhao, Sean T. Zuckerman, Chuanqi Cai, Michael L. Simeon, Avishek Singh, Sreenivasulu Kilari, Julius N. Korley, Sanjay Misra   +7 more
doaj   +1 more source

TRIM21 and Fc-engineered antibodies: decoding its complex antibody binding mode with implications for viral neutralization

Frontiers in Immunology
TRIM21 is a pivotal effector in the immune system, orchestrating antibody-mediated responses and modulating immune signaling. In this comprehensive study, we focus on the interaction of TRIM21 with Fc engineered antibodies and subsequent implications for
Johannes Reusch, Linda Elise Franken, Jakob Then, Philippe Ringler, Philippe Ringler, Joachim Butzer, Thomas Juroschek, Christian Klein, Tilman Schlothauer, Laurent Larivière   +9 more
doaj   +1 more source

Regulation of integrin α5β1 conformational states and intrinsic affinities by metal ions and the ADMIDAS

, 2022
Jordan M. Anderson, Jing Li, Timothy A. Springer   +2 more
openalex   +2 more sources

On Affinity Measures for Artificial Immune System Movie Recommenders

, 2008
We combine Artificial Immune Systems 'AIS', technology with Collaborative Filtering 'CF' and use it to build a movie recommendation system. We already know that Artificial Immune Systems work well as movie recommenders from previous work by Cayzer and ...
Aickelin, Uwe, Chen, Qi
core   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

The N-terminal second intracellular loop (2 NI) of the high-affinity CCK-A receptor is coupled to the intracellular PLA2-arachidonic acid cascade

, 2000
Yasuhiro Tsunoda, Il Song, Chung Owyang
openalex   +1 more source

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source