Results 101 to 110 of about 1,074,495 (313)

Integrated lectin affinity microfluidic chip for glycoform separation

, 2004
Lectin affinity chromatography was miniaturized into a microfluidic format, which results in improvement of performance, as compared to the conventional method.
Wang, KY, Mao, XL, Luo, Y, Du, YG, Dai, ZP, Lin, BC   +5 more
core   +1 more source

Current state of open source force fields in protein-ligand binding affinity predictions

, 2023
In drug discovery, the in-silico prediction of binding affinity is one of the major means to prioritize compounds for synthesis. Alchemical relative binding free energy (RBFE) calculations based on molecular dynamics (MD) simulations is nowadays a ...
David F., Hahn, Vytautas, Gapsys, Bert L., de Groot, Gary J., Tresadern, David L., Mobley   +4 more
core   +1 more source

Predicted binding affinity of candidate HDV epitope: a bioinformatics study

Annals of Hepatology, 2007
Hepatitis D virus (HDV) is an RNA virus that can cause hepatitis. Development and approval of new vaccines are the hope for control of the possible emerging pandemic of this infection.
Viroj Wiwanitkit
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

A high affinity nitrate transport system from Chlamydomonas requires two gene products

, 2000
A nitrate-regulated cluster of genes involved in nitrate transport and assimilation has been identified in Chlamydomonas reinhardtii. Mutant strains of the alga, which are defective in some aspect of transport and assimilation have been used to assign ...
Galvan, A., Miller, A. J., Zhou, J-J., Fernandez, E.   +3 more
core   +1 more source

PHYLOGENETIC ANALYSIS OF ROBUSTA COFFEE (Coffea Canephora PIERRE EX FROCHNER) BASED ON MORPHOLOGICAL CHARACTERISTIC AND CLASS PROXIMITY

Jurnal Agrotek Tropika
In Indonesia, the most commonly cultivated type of coffee is Robusta coffee. Robusta coffee is a polyclonal plant, so its production can be increased by planting several superior clones in an area.
Sri Nurmayanti, Muhammad Tahir, Wiwik Indrawati, Bawon Mahhendra, Resti Puspa Kartika Sari   +4 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Interrogation of the protein-protein interactions between human BRCA2 BRC repeats and RAD51 reveals atomistic determinants of affinity

, 2011
The breast cancer suppressor BRCA2 controls the recombinase RAD51 in the reactions that mediate homologous DNA recombination, an essential cellular process required for the error-free repair of DNA double-stranded breaks.
Rajendra, Eason, Skylaris Chris-Kriton, Cole, Daniel J., Venkitaraman Ashok R., Hardwick, Bryn, Payne, Mike C., Mike C. Payne, McKenzie, Grahame J., Grahame J. McKenzie, Cole Daniel J., Mike C Payne, Hardwick Bryn, McKenzie Grahame J., Bryn Hardwick, Grahame J McKenzie, Ashok R Venkitaraman, Chris-Kriton Skylaris, Daniel J Cole, Ashok R. Venkitaraman, Eeson Rajendra, Roberts-Thomson Meredith, Skylaris, Chris-Kriton, Payne Mike C., Kowalczykowski, Stephen Charles, Venkitaraman, Ashok R., Rajendra Eeson, Roberts-Thomson, Meredith, Daniel J. Cole, Meredith Roberts-Thomson   +28 more
core   +1 more source

Crystallographic analysis reveals the structural basis of the high-affinity binding of iophenoxic acid to human serum albumin [PDF]

, 2011
23.04.14 KB.
Chung, Chun-wa, Curry, Stephen, Ali J Ryan, Chun-wa Chung, Stephen Curry, Curry, S, Ryan, AJ, Chung, C-W, Ryan, Ali J.   +8 more
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source