Results 11 to 20 of about 329,197 (260)
Toward Glycomaterials with Selectivity as Well as Affinity
JACS Au, 2021 Multivalent glycosylated materials (polymers, surfaces, and particles) often show high affinity toward carbohydrate binding proteins (e.g., lectins) due to the nonlinear enhancement from the cluster glycoside effect. This affinity gain has potential in applications from diagnostics, biosensors, and targeted delivery to anti-infectives and in an ...
Sarah-Jane Richards, Matthew I. Gibson
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Engaging an HIV vaccine target through the acquisition of low B cell affinity
Nature Communications, 2023 Low affinity is common for germline B cell receptors (BCR) seeding development of broadly neutralizing antibodies (bnAbs) that engage hypervariable viruses, including HIV. Antibody affinity selection is also non-homogenizing, insuring the survival of low
Larance Ronsard +12 more
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Robust Unsupervised Hyperspectral Band Selection via Global Affinity Matrix Reconstruction
IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2023 Unsupervised band selection is fundamental to alleviate the curse of dimensionality for hyperspectral imagery. Although many research works have been developed, it is still a challenging problem to improve the poor classification performance with a small
Mengbo You +3 more
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Representations of Affine Multifunctions by Affine Selections [PDF]
Set-Valued Analysis, 2008 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
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Generating Recombinant Antibodies to Membrane Proteins through Phage Display
Antibodies, 2016 One of the most important classes of proteins in terms of drug targets is cell surface membrane proteins, and yet it is a challenging set of proteins for generating high-quality affinity reagents.
Renhua Huang +4 more
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Antibodies, 2017 Membrane proteins are attractive targets for monoclonal antibody (mAb) discovery and development. Although several approved mAbs against membrane proteins have been isolated from phage antibody libraries, the process is challenging, as it requires the ...
Mohamed A. Alfaleh +3 more
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Engineering Reports, 2020 Efficient selection of nucleic acid aptamers with high affinity and specificity for a broad range of targets remains challenging. Historically, aptamer selections have been protracted and tedious processes, often requiring double‐digit rounds of ...
Jonah C. Rosch +3 more
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A Population Dynamics Model for Clonal Diversity in a Germinal Center
Frontiers in Microbiology, 2017 Germinal centers (GCs) are micro-domains where B cells mature to develop high affinity antibodies. Inside a GC, B cells compete for antigen and T cell help, and the successful ones continue to evolve.
Assaf Amitai +9 more
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Improved Clonal Selection Algorithm Based on Biological Forgetting Mechanism
Complexity, 2020 The antibody candidate set generated by the clonal selection algorithm has only a small number of antibodies with high antigen affinity to obtain high-frequency mutations.
Chao Yang +3 more
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Frontiers in Immunology, 2020 MHC-independent αβTCRs (TCRs) recognize conformational epitopes on native self-proteins and arise in mice lacking both MHC and CD4/CD8 coreceptor proteins. Although naturally generated in the thymus, these TCRs resemble re-engineered therapeutic chimeric
François Van Laethem +13 more
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