Results 11 to 20 of about 738,160 (293)

Engaging an HIV vaccine target through the acquisition of low B cell affinity

Nature Communications, 2023
Low affinity is common for germline B cell receptors (BCR) seeding development of broadly neutralizing antibodies (bnAbs) that engage hypervariable viruses, including HIV. Antibody affinity selection is also non-homogenizing, insuring the survival of low
Larance Ronsard, Ashraf S. Yousif, Faez Amokrane Nait Mohamed, Jared Feldman, Vintus Okonkwo, Caitlin McCarthy, Julia Schnabel, Timothy Caradonna, Ralston M. Barnes, Daniel Rohrer, Nils Lonberg, Aaron Schmidt, Daniel Lingwood   +12 more
doaj   +1 more source

Anti-HA Glycoforms Drive B Cell Affinity Selection and Determine Influenza Vaccine Efficacy. [PDF]

Cell, 2015
Wang TT, Maamary J, Tan GS, Bournazos S, Davis CW, Krammer F, Schlesinger SJ, Palese P, Ahmed R, Ravetch JV.   +9 more
europepmc   +2 more sources

Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents. [PDF]

, 2008
Following our previous research on anti-inflammatory drugs (NSAIDs), we report here the synthesis of chiral 1,5-diarylpyrroles derivatives that were characterized for their in vitro inhibitory effects toward cyclooxygenase (COX) isozymes.
ANZELLOTTI P., ANZINI M., BIAVA M., BOTTA M., CIRILLI R., FERRETTI R., FORLI ., GALLINELLA B., GHELARDINI C., GIORDANI A., LA TORRE F., MAKOVEC F., MANETTI F., NORCINI M., PATRIGNANI P., PERGOLA C., POCE G., PORRETTA G. C., ROSSI, ANTONIETTA, SAUTEBIN, LIDIA, SUPINO S.   +20 more
core   +1 more source

Generating Recombinant Antibodies to Membrane Proteins through Phage Display

Antibodies, 2016
One of the most important classes of proteins in terms of drug targets is cell surface membrane proteins, and yet it is a challenging set of proteins for generating high-quality affinity reagents.
Renhua Huang, Margaret M. Kiss, Melissa Batonick, Michael P. Weiner, Brian K. Kay   +4 more
doaj   +1 more source

Strategies for Selecting Membrane Protein-Specific Antibodies using Phage Display with Cell-Based Panning

Antibodies, 2017
Membrane proteins are attractive targets for monoclonal antibody (mAb) discovery and development. Although several approved mAbs against membrane proteins have been isolated from phage antibody libraries, the process is challenging, as it requires the ...
Mohamed A. Alfaleh, Martina L. Jones, Christopher B. Howard, Stephen M. Mahler   +3 more
doaj   +1 more source

A systematic evolution of ligands by exponential enrichment workflow with consolidated counterselection to efficiently isolate high‐affinity aptamers

Engineering Reports, 2020
Efficient selection of nucleic acid aptamers with high affinity and specificity for a broad range of targets remains challenging. Historically, aptamer selections have been protracted and tedious processes, often requiring double‐digit rounds of ...
Jonah C. Rosch, Daniel A. Balikov, Franklin Gong, Ethan S. Lippmann   +3 more
doaj   +1 more source

Representations of Affine Multifunctions by Affine Selections [PDF]

Set-Valued Analysis, 2008
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

ZRT1 harbors an excess of nonsynonymous polymorphism and shows evidence of balancing selection in Saccharomyces cerevisiae [PDF]

, 2012
Estimates of the fraction of nucleotide substitutions driven by positive selection vary widely across different species. Accounting for different estimates of positive selection has been difficult, in part because selection on polymorphism within a ...
Engle, Elizabeth K., Fay, Justin C.
core   +3 more sources

Selection of functional human antibodies from retroviral display libraries [PDF]

, 2004
Antibody library technology represents a powerful tool for the discovery and design of antibodies with high affinity and specificity for their targets.
Urban, Johannes H., Schneider, Richard M., Compte, Marta, Finger, Carsten, Cichutek, Klaus, Álvarez-Vallina, Luis, Buchholz, Christian   +6 more
core   +2 more sources

mRNA Display Design of Fibronectin-based Intrabodies That Detect and Inhibit Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Protein [PDF]

, 2009
The nucleocapsid (N) protein of severe acute respiratory syndrome (SARS) coronavirus plays important roles in both viral replication and modulation of host cell processes.
Amstutz, C. Anders Olson, Cardinale, Cardinale, Carlson, Carter, Chakrabarti, Chang, Chen, Elaine Wong, Enjuanes, Hongyu Deng, Hosse, Hsiang-I. Liao, Ja, Kawe, Koide, Lipovsek, Liu, Luo, Maynard, Milligan, Nizak, Olson, Olson, Rajpal, Ralph S. Baric, Ren Sun, Richard W. Roberts, Roberts, Roberts, Rota, Saikatendu, Satija, Seungmin Hwang, Stocks, Surjit, Vascotto, Visintin, Yount, Yu   +40 more
core   +4 more sources