Results 21 to 30 of about 329,197 (260)

Amount of antigen, T follicular helper cells and affinity of founder cells shape the diversity of germinal center B cells: A computational study

Frontiers in Immunology, 2023
A variety of B cell clones seed the germinal centers, where a selection stringency expands the fitter clones to generate higher affinity antibodies. However, recent experiments suggest that germinal centers often retain a diverse set of B cell clones ...
Amar K. Garg, Tanmay Mitra, Marta Schips, Arnab Bandyopadhyay, Michael Meyer-Hermann, Michael Meyer-Hermann   +5 more
doaj   +1 more source

Improving Pharmacokinetics of Peptides Using Phage Display

Viruses
Phage display is a versatile method often used in the discovery of peptides that targets disease-related biomarkers. A major advantage of this technology is the ease and cost efficiency of affinity selection, also known as biopanning, to identify novel ...
Mallika Asar, Jessica Newton-Northup, Mette Soendergaard   +2 more
doaj   +1 more source

A stepwise and digital pattern of RSK phosphorylation determines the outcome of thymic selection

iScience, 2023
Summary: Developing CD4+CD8+ double-positive (DP) thymocytes with randomly generated T cell receptors (TCRs) undergo positive (maturation) or negative (apoptosis) selection on the basis of the strength of TCR stimulation.
Shintaro Funasaki, Atsushi Hatano, Hirokazu Nakatsumi, Daisuke Koga, Osamu Sugahara, Kanae Yumimoto, Masaya Baba, Masaki Matsumoto, Keiichi I. Nakayama   +8 more
doaj   +1 more source

Learning a Robust Local Manifold Representation for Hyperspectral Dimensionality Reduction

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2017
Local manifold learning has been successfully applied to hyperspectral dimensionality reduction in order to embed nonlinear and nonconvex manifolds in the data.
Danfeng Hong, Naoto Yokoya, Xiao Xiang Zhu   +2 more
doaj   +1 more source

A mechanism of T cell dependent selection of antigen engaged Germinal Center B cells. [PDF]

PLoS ONE, 2018
A model of B cell affinity selection is proposed, and an explanation of peripheral tolerance mechanisms through antibody repertoire editing is presented.
Vinod Krishna, Kurtis E Bachman
doaj   +1 more source

Rapid de novo discovery of peptidomimetic affinity reagents for human angiotensin converting enzyme 2

Communications Chemistry, 2022
Angiotensin converting enzyme 2 (ACE2) has been identified as a cardiovascular disease biomarker and the primary receptor utilized by SARS-CoV-2, but developing serum-stable, selective and high-affinity binders for this target is challenging.
Genwei Zhang, Joseph S. Brown, Anthony J. Quartararo, Chengxi Li, Xuyu Tan, Stephanie Hanna, Sarah Antilla, Amanda E. Cowfer, Andrei Loas, Bradley L. Pentelute   +9 more
doaj   +1 more source

Yeast Surface Display Platform for Rapid Selection of an Antibody Library via Sequential Counter Antigen Flow Cytometry

Antibodies, 2022
Yeast surface display techniques have been increasingly employed as a tool for both the discovery and affinity maturation of antibodies. In this study, we describe the use of yeast surface display for the selection and affinity maturation of antibodies ...
Bhupal Ban, Robert C. Blake, Diane A. Blake   +2 more
doaj   +1 more source

Machine Learning to Quantify In Situ Humoral Selection in Human Lupus Tubulointerstitial Inflammation

Frontiers in Immunology, 2020
In human lupus nephritis, tubulointerstitial inflammation (TII) is associated with in situ expansion of B cells expressing anti-vimentin antibodies (AVAs). The mechanism by which AVAs are selected is unclear.
Andrew J. Kinloch, Yuta Asano, Azam Mohsin, Carole Henry, Rebecca Abraham, Anthony Chang, Christine Labno, Patrick C. Wilson, Marcus R. Clark   +8 more
doaj   +1 more source

Long-Lived Plasma Cells Secrete High-Affinity Antibodies Responding to a T-Dependent Immunization in a Teleost Fish

Frontiers in Immunology, 2019
The recent discovery of long-lived plasma cells (LLPCs) in mammals, which provide a constant expression of specific high-affinity antibodies that mediate humoral memory, has caused a dramatic paradigm shift in the study of immunity and vaccine ...
Liting Wu, Shengli Fu, Xiaoxue Yin, Zheng Guo, Anli Wang, Jianmin Ye   +5 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source