Results 21 to 30 of about 738,160 (293)
Epitope mapping using mRNA display and a unidirectional nested deletion library [PDF]
, 2005 In vitro selection targeting an anti-polyhistidine monoclonal antibody was performed using mRNA display with a random, unconstrained 27-mer peptide library.
Ja, William W. +2 more
core +1 more source
Frontiers in Immunology, 2020 MHC-independent αβTCRs (TCRs) recognize conformational epitopes on native self-proteins and arise in mice lacking both MHC and CD4/CD8 coreceptor proteins. Although naturally generated in the thymus, these TCRs resemble re-engineered therapeutic chimeric
François Van Laethem +13 more
doaj +1 more source
A Population Dynamics Model for Clonal Diversity in a Germinal Center
Frontiers in Microbiology, 2017 Germinal centers (GCs) are micro-domains where B cells mature to develop high affinity antibodies. Inside a GC, B cells compete for antigen and T cell help, and the successful ones continue to evolve.
Assaf Amitai +9 more
doaj +1 more source
Improved Clonal Selection Algorithm Based on Biological Forgetting Mechanism
Complexity, 2020 The antibody candidate set generated by the clonal selection algorithm has only a small number of antibodies with high antigen affinity to obtain high-frequency mutations.
Chao Yang +3 more
doaj +1 more source
Semantic media decision taking using N3Logic [PDF]
, 2011 In this paper, we introduce a media decision taking engine (MDTE), enabling the automatic selection and/or rating of multimedia content versions, based on the available context information.
Van de Walle, Rik +3 more
core +2 more sources
Frontiers in Immunology, 2023 A variety of B cell clones seed the germinal centers, where a selection stringency expands the fitter clones to generate higher affinity antibodies. However, recent experiments suggest that germinal centers often retain a diverse set of B cell clones ...
Amar K. Garg +5 more
doaj +1 more source
Did Germinal Centers evolve under differential effects of diversity vs affinity? [PDF]
, 2006 The classical view on the process of mutation and affinity maturation that occurs in GCs assumes that their major role is to generate high affinity levels of serum Abs, as well as a dominant pool of high affinity memory B cells, through a very ...
Combadão, J., Faro, J., Gordo, I.
core +1 more source
Improving Pharmacokinetics of Peptides Using Phage Display
VirusesPhage display is a versatile method often used in the discovery of peptides that targets disease-related biomarkers. A major advantage of this technology is the ease and cost efficiency of affinity selection, also known as biopanning, to identify novel ...
Mallika Asar +2 more
doaj +1 more source
A mechanism of T cell dependent selection of antigen engaged Germinal Center B cells. [PDF]
PLoS ONE, 2018 A model of B cell affinity selection is proposed, and an explanation of peripheral tolerance mechanisms through antibody repertoire editing is presented.
Vinod Krishna, Kurtis E Bachman
doaj +1 more source
A stepwise and digital pattern of RSK phosphorylation determines the outcome of thymic selection
iScience, 2023 Summary: Developing CD4+CD8+ double-positive (DP) thymocytes with randomly generated T cell receptors (TCRs) undergo positive (maturation) or negative (apoptosis) selection on the basis of the strength of TCR stimulation.
Shintaro Funasaki +8 more
doaj +1 more source