Results 41 to 50 of about 329,197 (260)
Scientific Reports, 2021 Small antibody mimetics that contain high-affinity target-binding peptides can be lower cost alternatives to monoclonal antibodies (mAbs). We have recently developed a method to create small antibody mimetics called FLuctuation-regulated Affinity ...
Kyra See +11 more
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Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Remarks on Bárány's theorem and affine selections
Discrete Mathematics, 2000 In this paper a generalized version of Helly's theorem given by Bárány is used to generalize other results originally based on Helly's theorem. The generalized version of Helly's theorem (also called ``multiplied'' version) states that if \({\mathcal K}_1,\ldots, {\mathcal K}_{n+1}\) are families of convex compact sets in \(R^n\) such that \(K_1\cap ...
Mircea Balaj, Kazimierz Nikodem
openaire +2 more sources
One-step selection of Vaccinia virus-binding DNA aptamers by MonoLEX
BMC Biotechnology, 2007 Background As a new class of therapeutic and diagnostic reagents, more than fifteen years ago RNA and DNA aptamers were identified as binding molecules to numerous small compounds, proteins and rarely even to complete pathogen particles.
Stöcklein Walter +11 more
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Probing the limits of aptamer affinity with a microfluidic SELEX platform. [PDF]
PLoS ONE, 2011 Nucleic acid-based aptamers offer many potential advantages relative to antibodies and other protein-based affinity reagents, including facile chemical synthesis, reversible folding, improved thermal stability and lower cost.
Kareem M Ahmad +5 more
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Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Conformational Dynamics of the Receptor-Binding Domain of the SARS-CoV-2 Spike Protein
Biomedicines, 2022 Variants of SARS-CoV-2 keep emerging and causing new waves of COVID-19 around the world. Effective new approaches in drug development are based on the binding of agents, such as neutralizing monoclonal antibodies to a receptor-binding domain (RBD) of ...
Aleksandra A. Mamchur +8 more
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Development of Recombinant Antibody by Yeast Surface Display Technology
Current Research in Pharmacology and Drug DiscoveryRecombinant antibodies have emerged as powerful tools in various fields, including therapeutics, diagnostics, and research applications. The selection of high-affinity antibodies with desired specificity is a crucial step in the development of ...
Mujahed I. Mustafa +2 more
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Parameters and determinants of responses to selection in antibody libraries.
PLoS Computational Biology, 2021 The sequences of antibodies from a given repertoire are highly diverse at few sites located on the surface of a genome-encoded larger scaffold. The scaffold is often considered to play a lesser role than highly diverse, non-genome-encoded sites in ...
Steven Schulz +6 more
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