Results 41 to 50 of about 738,160 (293)

Toward Glycomaterials with Selectivity as Well as Affinity

JACS Au, 2021
Multivalent glycosylated materials (polymers, surfaces, and particles) often show high affinity toward carbohydrate binding proteins (e.g., lectins) due to the nonlinear enhancement from the cluster glycoside effect. This affinity gain has potential in applications from diagnostics, biosensors, and targeted delivery to anti-infectives and in an ...
Sarah-Jane Richards, Matthew I. Gibson
openaire   +4 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phage Display’s Prospects for Early Diagnosis of Prostate Cancer

Viruses
Prostate cancer (PC) is the second most diagnosed cancer among men. It was observed that early diagnosis of disease is highly beneficial for the survival of cancer patients.
Valery A. Petrenko
doaj   +1 more source

Optimality of mutation and selection in germinal centers. [PDF]

PLoS Computational Biology, 2010
The population dynamics theory of B cells in a typical germinal center could play an important role in revealing how affinity maturation is achieved. However, the existing models encountered some conflicts with experiments. To resolve these conflicts, we
Jingshan Zhang, Eugene I Shakhnovich
doaj   +1 more source

Pepitope: epitope mapping from affinity-selected peptides [PDF]

Bioinformatics, 2007
AbstractIdentifying the epitope to which an antibody binds is central for many immunological applications such as drug design and vaccine development. The Pepitope server is a web-based tool that aims at predicting discontinuous epitopes based on a set of peptides that were affinity-selected against a monoclonal antibody of interest.
Itay, Mayrose, Osnat, Penn, Elana, Erez, Nimrod D, Rubinstein, Tomer, Shlomi, Natalia Tarnovitski, Freund, Erez M, Bublil, Eytan, Ruppin, Roded, Sharan, Jonathan M, Gershoni, Eric, Martz, Tal, Pupko   +11 more
openaire   +2 more sources

Monte Carlo study of gating and selection in potassium channels

, 2011
The study of selection and gating in potassium channels is a very important issue in modern biology. Indeed such structures are known in all types of cells in all organisms where they play many important functional roles.
A. L. Hodgkin, A. M. J. VanDongen, B. Hille, Daniele Andreucci, Dario Bellaveglia, Emilio N. M. Cirillo, Silvia Marconi   +6 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Long-Lived Plasma Cells Secrete High-Affinity Antibodies Responding to a T-Dependent Immunization in a Teleost Fish

Frontiers in Immunology, 2019
The recent discovery of long-lived plasma cells (LLPCs) in mammals, which provide a constant expression of specific high-affinity antibodies that mediate humoral memory, has caused a dramatic paradigm shift in the study of immunity and vaccine ...
Liting Wu, Shengli Fu, Xiaoxue Yin, Zheng Guo, Anli Wang, Jianmin Ye   +5 more
doaj   +1 more source

The cloning, characterisation and engineering of an IGF-I-BINDING single chain Fv [PDF]

, 2004
This thesis describes the construction and characterisation of an insulin-like growth factor (IGF-I)-binding single chain Fv (scFv) and the utilisation of this scFv as a model protein for the study of the application of DNA shuffling and ribosome display
Roberts, Anthony Simon
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source