Studies on the molecular evolution (affinity maturation) of antibodies: unexpected encounter [PDF]
, 2015 Antibodies are unique proteins in that they improve their affinity for antigens during antibody responses. This process termed “affinity maturation” is the result of random hypermutation of immunoglobulin genes in B cells followed by selection of the ...
Ohmori, Hitoshi
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Methods for cell- and tissue-specific DNA aptamer selection
Molecular Therapy: Methods & Clinical DevelopmentAptamers are folded single-stranded DNA or RNA molecules with high affinity for target small molecules, proteins, cells, or tissues. Affinity arises from the three-dimensional structure of the aptamer.
Brandon A. Wilbanks +5 more
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The Symmetrical Immune Network Theory and a New HIV Vaccine Concept [PDF]
, 2010 The symmetrical immune network theory is based on Jerne’s network hypothesis. An improved version of the theory is presented. The theory is characterized by symmetrical stimulatory, inhibitory and killing interactions between idiotypic and ...
Geoffrey W. Hoffmann
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Understanding T regulatory cell development in the thymus using both in vivo and in vitro models [PDF]
, 2008 only availableMultiple sclerosis (MS) is an autoimmune disease caused by autoreactive T cells attacking myelin sheath proteins in nerve fibers of the central nervous system resulting in paralysis and death.
Cascio, Jason +3 more
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Novel Nucleic Acid Binding Small Molecules Discovered Using DNA-Encoded Chemistry
Molecules, 2019 Inspired by the many reported successful applications of DNA-encoded chemical libraries in drug discovery projects with protein targets, we decided to apply this platform to nucleic acid targets.
Alexander Litovchick +8 more
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Band Selection Algorithm Based on Multi-Feature and Affinity Propagation Clustering
Remote SensingHyperspectral images are high-dimensional data containing rich spatial, spectral, and radiometric information, widely used in geological mapping, urban remote sensing, and other fields.
Junbin Zhuang +3 more
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Cell Reports, 2018 Summary: Antibody affinity maturation, which is an antigen-based selection process for B cells, occurs in germinal centers (GCs). GCB cells must efficiently recognize, acquire, and present antigens from follicular dendritic cells (FDCs) to receive ...
Jingjing Chen +12 more
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Inferring processes underlying B-cell repertoire diversity
, 2015 We quantify the VDJ recombination and somatic hypermutation processes in human B-cells using probabilistic inference methods on high-throughput DNA sequence repertoires of human B-cell receptor heavy chains.
Aleksandra M. Walczak +10 more
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Modeling Social Networks with Node Attributes using the Multiplicative Attribute Graph Model [PDF]
, 2011 Networks arising from social, technological and natural domains exhibit rich connectivity patterns and nodes in such networks are often labeled with attributes or features.
Kim, Myunghwan, Leskovec, Jure
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Reconstructing a B-cell Clonal Lineage. II. Mutation, Selection, and Affinity Maturation
Frontiers in Immunology, 2014 Affinity maturation of the antibody response is a fundamental process in adaptive immunity during which B cells activated by infection or vaccination undergo rapid proliferation accompanied by the acquisition of point mutations in their rearranged ...
Thomas B. Kepler +12 more
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