Results 81 to 90 of about 733,038 (191)

Recycling probability and dynamical properties of germinal center reactions

, 2001
We introduce a new model for the dynamics of centroblasts and centrocytes in a germinal center. The model reduces the germinal center reaction to the elements considered as essential and embeds proliferation of centroblasts, point mutations of the ...
Deutsch, Andreas, Meyer-Hermann, Michael, Or-Guil, Michal   +2 more
core   +2 more sources

Nucleotide context models outperform protein language models for predicting antibody affinity maturation.

PLoS Computational Biology
Antibodies play a crucial role in adaptive immunity. They develop as B cell receptors (BCRs): membrane-bound forms of antibodies that are expressed on the surfaces of B cells.
Mackenzie M Johnson, Kevin Sung, Hugh K Haddox, Ashni A Vora, Tatsuya Araki, Gabriel D Victora, Yun S Song, Julia Fukuyama, Frederick A Matsen Iv   +8 more
doaj   +1 more source

Microfluidic affinity selection of active SARS-CoV-2 virus particles. [PDF]

Sci Adv, 2022
Gamage SST, Pahattuge TN, Wijerathne H, Childers K, Vaidyanathan S, Athapattu US, Zhang L, Zhao Z, Hupert ML, Muller RM, Muller-Cohn J, Dickerson J, Dufek D, Geisbrecht BV, Pathak H, Pessetto Z, Gan GN, Choi J, Park S, Godwin AK, Witek MA, Soper SA.   +21 more
europepmc   +1 more source

Ranking to Learn: Feature Ranking and Selection via Eigenvector Centrality

, 2017
In an era where accumulating data is easy and storing it inexpensive, feature selection plays a central role in helping to reduce the high-dimensionality of huge amounts of otherwise meaningless data.
Melzi, Simone, Roffo, Giorgio
core  

Development and application of a customized online affinity selection mass spectrometry screening platform

SLAS Technology
With the evolving landscape of small molecule modalities and drug target portfolios, affinity selection mass spectrometry (ASMS) has emerged as a preferred high-throughput screening approach, driven by the growing chemical space capable of regulating ...
Jun Zhang, Jerry Barney, Qingqing Shen, Anthony Paiva, Wilson Shou, Chris Barbieri, Nancy Huynh, Heidi L. Perez, Andrew F. Donnell, Cullen L. Cavallaro   +9 more
doaj   +1 more source

Collision-Induced Affinity Selection Mass Spectrometry for Identification of Ligands. [PDF]

ACS Bio Med Chem Au, 2022
Mak T, Rossjohn J, Littler DR, Liu M, Quinn RJ.   +4 more
europepmc   +1 more source

Affinity selection of double-click triazole libraries for rapid discovery of allosteric modulators for GLP-1 receptor. [PDF]

Proc Natl Acad Sci U S A, 2023
Xin Y, Liu S, Liu Y, Qian Z, Liu H, Zhang B, Guo T, Thompson GJ, Stevens RC, Sharpless KB, Dong J, Shui W.   +11 more
europepmc   +1 more source

Drug discovery from natural products using affinity selection-mass spectrometry. [PDF]

Drug Discov Today Technol, 2021
Muchiri RN, van Breemen RB.
europepmc   +1 more source

Automated affinity selection for rapid discovery of peptide binders. [PDF]

Chem Sci, 2021
Zhang G, Li C, Quartararo AJ, Loas A, Pentelute BL.   +4 more
europepmc   +1 more source

Advances in Magnetic Microbead Affinity Selection Screening: Discovery of Natural Ligands to the SARS-CoV-2 Spike Protein. [PDF]

J Am Soc Mass Spectrom, 2022
Muchiri RN, Kibitel J, Redick MA, van Breemen RB.   +3 more
europepmc   +1 more source