Results 71 to 80 of about 2,737,561 (202)

Genotype II Live‐Attenuated ASFV Vaccine Bearing 24 Genes Deletion in 3 Independent Regions Is Able to Provide Complete Protection Against Homologous Lethal Challenge

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
African swine fever (ASF) is a highly contagious and lethal viral disease of swine. Therefore, it is urgent to develop a safe and effective vaccine. We constructed a live‐attenuated ASF vaccine bearing 24 gene deletions in 3 independent regions, ASFV‐Δ24.
Fan Xu, Wen Dang, Yu Du, Tao Li, Huanan Liu, Zhengwang Shi, Hong Tian, Jijun He, Haixue Zheng   +8 more
wiley   +1 more source

Co-Deletion of A238L and EP402R Genes from a Genotype IX African Swine Fever Virus Results in Partial Attenuation and Protection in Swine

Viruses, 2022
African swine fever virus (ASFV) is the causative agent of African swine fever (ASF), resulting in up to 100% mortality in pigs. Although endemic in most sub-Saharan African countries, where all known ASFV genotypes have been reported, the disease has ...
Hussein M. Abkallo, Johanneke D. Hemmink, Bernard Oduor, Emmanuel M. Khazalwa, Nicholas Svitek, Nacyra Assad-Garcia, Jeremiah Khayumbi, Walter Fuchs, Sanjay Vashee, Lucilla Steinaa   +9 more
doaj   +1 more source

Transcriptomic and Metabolomic Profiling Identifies a Core Gene–Metabolite Axis Driving African Swine Fever Virus Replication in the Soft Tick Ornithodoros lahorensis

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
Transcriptomic and metabolomic profiling of Ornithodoros lahorensis during African swine fever virus (ASFV) infection reveals that ASFV rewires host purine/pyrimidine metabolism, lipid metabolism, and energy metabolism. A core gene‐metabolite regulatory axis consisting of 12 key genes and 8 signature metabolites is identified to support viral genome ...
Jin Luo, Kaifei Guo, Fangyu Xiao, Ruoqi Wang, Junhui Guo, Qiaoyun Ren, Shuaiyang Zhao, Muhammad Kashif Obaid, Guiquan Guan, Hong Yin   +9 more
wiley   +1 more source

Evaluation of Multi‐Stakeholder Perspectives on the Preparedness of Ghana's Animal Health Services for African Swine Fever Control: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background and Aims African Swine Fever (ASF) is a highly fatal viral disease of pigs that has persisted in Ghana since its first introduction in 1999, causing recurrent outbreaks with devastating socioeconomic consequences for livelihoods and food security.
Emmanuel Allege‐Cudjoe, Benjamin Obukowho Emikpe, Evans Nsoh Ayamdooh, Mabel Abudu, Helena Naa Baake Acquah, Abdul Rahman Yakubu, Sampson Yeboah, Prince Nana Takyi, Joseph Kofi Abuh, Patrick Amponsah Mensah, Emmanuel Eshun, Felix Doe, Patrick Ababio, Emmah Nafula Kwoba, Edmond Onidje, Ziekah Yiryele Meyir, William Tasiame, Joseph Atawalna, Garba Maina Ahmed, Marcel Ohoukou Boka, Abebe Wolde, Anthony Akunzule, Charles Mensah, Edward Danso Fenteng   +23 more
wiley   +1 more source

Comparative Analysis of African Swine Fever Virus Genotypes and Serogroups

, 2015
African swine fever virus (ASFV) causes highly lethal hemorrhagic disease among pigs, and ASFV’s extreme antigenic diversity hinders vaccine development. We show that p72 ASFV phylogenetic analysis does not accurately define ASFV hemadsorption inhibition
Galina Burmakina, Ilya Titov, Alexander Malogolovkin, Alexey Sereda, Andrey Gogin, Elena Baryshnikova, Denis Kolbasov   +6 more
core   +1 more source

Adaptive Cellular Immunity against African Swine Fever Virus Infections [PDF]

, 2022
African swine fever virus (ASFV) remains a threat to global pig populations. Infections with ASFV lead to a hemorrhagic disease with up to 100% lethality in Eurasian domestic and wild pigs.
Giulia Franzoni, Ulrike Blohm, Luise Hartmann, Hartmann, Luise, Christopher L. Netherton, Blome, Sandra, Sandra Blome, Franzoni, Giulia, Netherton, Christopher L., Blohm, Ulrike, Schäfer, Alexander, Alexander Schäfer   +11 more
core   +1 more source

Identification of a Continuously Stable and Commercially Available Cell Line for the Identification of Infectious African Swine Fever Virus in Clinical Samples

Viruses, 2020
African swine fever virus (ASFV) is causing outbreaks both in domestic pigs and wild boar in Europe and Asia. In 2018, the largest pig producing country, China, reported its first outbreak of African swine fever (ASF). Since then, the disease has quickly
Ayushi Rai, Sarah Pruitt, Elizabeth Ramirez-Medina, Elizabeth A. Vuono, Ediane Silva, Lauro Velazquez-Salinas, Consuelo Carrillo, Manuel V. Borca, Douglas P. Gladue   +8 more
doaj   +1 more source

Integrated one‐pot CRISPR‐Cas detection: Addressing strategies and future prospects

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
Integrated one‐pot CRISPR‐Cas detection significantly simplifies workflows, reduces cross‐contamination risks, and shortens turnaround times, making it highly suitable for point‐of‐care testing (POCT) and resource‐limited settings. Key challenges include system compatibility issues between Cas proteins and isothermal amplification, limited multiplexing
Jian Zhou, Xuemei Ren, Yingjie Ren, Ruiping Wu, Ruiman Geng, Le Chen, Zhuo Li   +6 more
wiley   +1 more source

The CP123L protein of African swine fever virus is a membrane-associated, palmitoylated protein required for viral replication

Journal of Virology
African swine fever (ASF) is a highly contagious and often lethal disease caused by African swine fever virus (ASFV) in pigs. Protein palmitoylation is a prevalent posttranslational lipid modification that can modulate viral replication.
Xiangyu Guan, Tao Wang, Yuxuan Gao, Huanjie Zhai, Fengwei Jiang, Qinghe Hou, Xiaoke Yang, Hongxia Wu, Lian-Feng Li, Yuzi Luo, Su Li, Yuan Sun, Hua-Ji Qiu, Yongfeng Li   +13 more
doaj   +1 more source

Evaluation of the Function of the ASFV KP177R Gene, Encoding for Structural Protein p22, in the Process of Virus Replication and in Swine Virulence

Viruses, 2021
African swine fever virus (ASFV) causes a devastating disease of swine that has caused outbreaks in Central Europe since 2007, spreading into Asia in 2018.
Elizabeth A. Vuono, Elizabeth Ramirez-Medina, Sarah Pruitt, Ayushi Rai, Nallely Espinoza, Lauro Velazquez-Salinas, Douglas P. Gladue, Manuel V. Borca   +7 more
doaj   +1 more source