Results 101 to 110 of about 511,853 (298)

Early mortality declines at the dawn of modern growth [PDF]

open access: yes
We explore the hypothesis that demographic changes started in the seventeenth and eighteenth centuries are at the root of the acceleration in growth rates at the dawn of the modern age. During this period, life tables for Geneva and Venice show a decline
David de la Croix   +2 more
core  

MOND cosmology from entropic force

open access: yes, 2012
We derive the MOND cosmology which is uniquely corresponding to the original MOND at galaxy scales via entropic gravity method. It inherits the key merit of MOND, that is, it reduces the baryonic matter and non-baryonic dark matter into baryonic matter
Li, Xin-Zhou, Zhang, Hongsheng
core   +1 more source

Stability of cylindrical thin shell wormhole during evolution of universe from inflation to late time acceleration [PDF]

open access: yes, 2015
In this paper, we consider the stability of cylindrical wormholes during evolution of universe from inflation to late time acceleration epochs. We show that there are two types of cylindrical wormholes.
Sepehri, A., Setare, M. R.
core   +2 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

A multistage theory of age-specific acceleration in human mortality

open access: yesBMC Biology, 2004
Background Humans die at an increasing rate until late in life, when mortality rates level off. The causes of the late-life mortality plateau have been debated extensively over the past few years. Here, I examine mortality patterns separately for each of
Frank Steven A
doaj   +1 more source

Attractive and Repulsive Gravity [PDF]

open access: yes, 2000
We discuss the circumstances under which gravity might be repulsive rather than attractive. In particular we show why our standard solar system distance scale gravitational intuition need not be a reliable guide to the behavior of gravitational phenomena
Mannheim, Philip D.
core   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

open access: yesFEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková   +3 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

Epigenetic age acceleration and allergic diseases: a bidirectional two-sample Mendelian randomization study

open access: yesClinical Epigenetics
Objective The epigenetic clock has been regarded as a highly accurate predictor of capturing the complexity between aging and the epigenome. However, there is limited understanding of the epigenetic clock in allergic diseases.
Junfang Sun   +4 more
doaj   +1 more source

Millisecond Pulsar Ages: Implications of Binary Evolution and a Maximum Spin Limit

open access: yes, 2010
In the absence of constraints from the binary companion or supernova remnant, the standard method for estimating pulsar ages is to infer an age from the rate of spin-down.
Arzoumanian   +20 more
core   +1 more source

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