Results 81 to 90 of about 511,853 (298)

Associations of DNA Methylation Algorithms of Aging With Cardiovascular Disease and Mortality Risk Among US Older Adults

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Several DNA methylation (DNAm) algorithms have recently emerged as robust predictors of aging and adverse health outcomes in older adults, offering valuable insights into cardiovascular disease (CVD) risk stratification.
Xian Cui, Shiqun Sun, Hui Zhang, Yulu Gong, Darong Hao, Yaqian Xu, Chongyu Ding, Jing Wang, Tongyan An, Jinlong Liu, Jun Du, Xiangwei Li   +11 more
doaj   +1 more source

Epigenetic gestational age acceleration: a prospective cohort study investigating associations with familial, sociodemographic and birth characteristics

Clinical Epigenetics, 2018
Background Gestational age at delivery is associated with health and social outcomes. Recently, cord blood DNA methylation data has been used to predict gestational age.
Jasmine N. Khouja, Andrew J. Simpkin, Linda M. O’Keeffe, Kaitlin H. Wade, Lotte C. Houtepen, Caroline L. Relton, Matthew Suderman, Laura D. Howe   +7 more
doaj   +1 more source

Progeria and Accelerated Cardiovascular Aging

Cardiology Plus, 2018
Hutchinson–Gilford Progeria syndrome (HGPS) is characterized by accelerated aging leading to death in the teen years, usually due to severe coronary and/or carotid disease. The clinical presentation includes stunted growth, alopecia, loss of subcutaneous fat, osteoporosis, and cardiovascular disorders occurring in late childhood and the teen years ...
Brandon K Walther, Yanhui Li, Rajarajan Amirthalingam Thandavarayan, John P Cooke   +3 more
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Accelerating Universe from an Evolving Lambda in Higher Dimension

, 2007
We find exact solutions in five dimensional inhomogeneous matter dominated model with a varying cosmological constant. Adjusting arbitrary constants of integration one can also achieve acceleration in our model.
A. Banerjee, A. Banerjee, A. Chodos, A.E. Romano, A.I. Arab, D. Panigrahi, D. Panigrahi, D. Sahdev, E. Guendelmann, H. Russ, J.A.S. Lima, J.M. Overduim, L. Randall, N. Mustapha, O. Grøn, P.S. Wesson, R., Cayrel, R.G. Viswakarma, R.G. Viswakarma, S. Chaterjee, S. Chatterjee, S. Chatterjee, S. Chatterjee, S. Ray, S., Perlmutter, Y. Tosa   +25 more
core   +1 more source

Noether Symmetries of a Modified Model in Teleparallel Gravity and a New Approach for Exact Solutions [PDF]

, 2017
In this paper, we have presented the Noether symmetries of flat FRW spacetime in the context of a new action in Teleparallel Gravity which we construct it based on $f(R)$ version.
Tajahmad, Behzad
core   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Nonthermal and thermal emission from the supernova remnant RX J1713.7-3946

, 2009
A nonlinear kinetic theory of cosmic ray (CR) acceleration in supernova remnants (SNRs) is employed to investigate the properties of SNR RX J1713.7-3946.
Berezhko, E. G., Voelk, H. J.
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

GrimAge and GrimAge2 Age Acceleration effectively predict mortality risk: a retrospective cohort study

Epigenetics
Epigenetic clocks have been widely applied to assess biological ageing, with Age Acceleration (AA) serving as a key metric linked to adverse health outcomes, including mortality.
Tieshi Zhu, Yong He, Yixi Wang, Le Zhao
doaj   +1 more source