Results 61 to 70 of about 511,853 (298)
Supernova Remnant Kes 17: Efficient Cosmic Ray Accelerator inside a Molecular Cloud
, 2012 Supernova remnant Kes 17 (SNR G304.6+0.1) is one of a few but growing number of remnants detected across the electromagnetic spectrum. In this paper, we analyze recent radio, X-ray, and gamma-ray observations of this object, determining that efficient ...
Castro, Daniel +5 more
core +1 more source
Social disadvantage accelerates aging
Nature MedicineAbstract Social disadvantage, like advanced age, is a risk factor for a broad range of health conditions; however, whether it influences the aging process remains unclear. Here, using a multicohort approach, we investigated the associations of social disadvantage with age-related plasma proteins and age-related diseases.
Kivimäki, M +11 more
openaire +3 more sources
Age-Specific Acceleration of Cancer [PDF]
Current Biology, 2004 One of the great challenges of cancer research is to explain the epidemiological patterns of cancer incidence based on the molecular processes that lead to uncontrolled cellular proliferation. The epidemiological data demonstrate that the age-specific incidence of many cancers increases in an approximately linear way with age when plotted on a log-log ...
openaire +2 more sources
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Acta Neuropathologica Communications, 2022 Elderly patients represent a growing proportion of individuals with glioblastoma, who however, are often excluded from clinical trials owing to poor expected prognosis.
Pierre Bady +11 more
doaj +1 more source
In-Situ Particle Acceleration in Extragalactic Radio Hot Spots: Observations Meet Expectations
, 2003 We discuss, in terms of particle acceleration, the results from optical VLT observations of hot spots associated with radio galaxies. On the basis of observational and theoretical grounds, it is shown that: 1. relatively low radio-radio power hot spots
Brunetti, G. +3 more
core +3 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Minkowski's Footprint revisited. Planetary Nebula formation from a single sudden event? [PDF]
, 2007 M1-92 can be considered an archetype of bipolar pre-planetary nebulae. It shows a clear axial symmetry, along with the kinematics and momentum excess characteristic of this class of envelopes around post-AGB stars. By taking advantage of the new extended
Arrieta +18 more
core +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Time to relapse in chronic lymphocytic leukemia and DNA-methylation-based biological age
Clinical Epigenetics, 2023 Chronic lymphocytic leukemia (CLL) is a mature B cell neoplasm with a predilection for older individuals. While previous studies have identified epigenetic signatures associated with CLL, whether age-related DNA methylation changes modulate CLL relapse ...
Drew R. Nannini +4 more
doaj +1 more source