Results 51 to 60 of about 511,853 (298)

DNA methylation age is accelerated in alcohol dependence. [PDF]

, 2018
Alcohol dependence (ALC) is a chronic, relapsing disorder that increases the burden of chronic disease and significantly contributes to numerous premature deaths each year.
Hlady, Ryan A, Horvath, Steve, Kaminsky, Zachary A, Lee, Jisoo, Lohoff, Falk W, Muench, Christine, Philibert, Robert, Robertson, Keith D, Rosen, Allison D   +8 more
core   +2 more sources

Obesity May Accelerate the Aging Process [PDF]

Frontiers in Endocrinology, 2019
Lines of evidence from several studies have shown that increases in life expectancy are now accompanied by increased disability rate. The expanded lifespan of the aging population imposes a challenge on the continuous increase of chronic disease. The prevalence of overweight and obesity is increasing at an alarming rate in many parts of the world ...
Salvestrini V., Sell C., Lorenzini A.
openaire   +3 more sources

DNA Methylation Algorithms of Aging and Incident Cardiovascular Disease: A Prospective Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background While DNA methylation (DNAm)‐based algorithms of aging show promise for predicting age‐related diseases, their comparative utility for incident cardiovascular disease (CVD) remains underexplored.
Xian Cui, Chunbei Yi, Hui Zhang, Yaqian Xu, Chongyu Ding, Zhaojun Wang, Shiqun Sun, Xiangwei Li   +7 more
doaj   +1 more source

Evidence for Cosmic Acceleration is Robust to Observed Correlations Between Type Ia Supernova Luminosity and Stellar Age

, 2020
Type Ia Supernovae (SNe Ia) are powerful standardizable candles for constraining cosmological models and provided the first evidence of the accelerated expansion of the universe.
Cikota, A., Deustua, S. E., Dixon, S., Fruchter, A., Jones, D. O., Riess, A. G., Rose, B. M., Rubin, D., Scolnic, D. M.   +8 more
core   +1 more source

Anxiety disorders and accelerated cellular ageing [PDF]

British Journal of Psychiatry, 2015
BackgroundAnxiety disorders increase the risk of onset of several ageing-related somatic conditions, which might be the consequence of accelerated cellular ageing.AimsTo examine the association between anxiety status and leukocyte telomere length (LTL) as an indicator of cellular ageing.MethodData are from individuals with current (n = 1283) and ...
Verhoeven, Josine E., Revesz, Dora, van Oppen, Patricia, Epel, Elissa S., Wolkowitz, Owen M., Penninx, Brenda W.   +5 more
openaire   +5 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Transient Accelerated Expansion and Double Quintessence

, 2004
We consider Double Quintessence models for which the Dark Energy sector consists of two coupled scalar fields. We study in particular the possibility to have a transient acceleration in these models. In both Double Quintessence models studied here, it is
David Blais, David Polarski, E. Halyo, J. L. Tonry, J. M. Cline, L. Järv, R. Kallosh, S. Hellerman, U. Alam, U. Franca, W. Fischler   +10 more
core   +2 more sources

The impact of a young radio galaxy : Clues from the cosmic ray electron population [PDF]

, 2014
In the framework of hierarchical structure formation, active galactic nuclei (AGN) feedback shapes the galaxy luminosity function. Low luminosity, galaxy-scale double radio sources are ideal targets to investigate the interplay between AGN feedback and ...
Croston, J.H., Hardcastle, M.J., Harwood, Jeremy J., Heesen, V., Hota, Ananda   +4 more
core   +2 more sources

Mechanical Deformation Accelerates Protein Ageing

Angewandte Chemie, 2017
AbstractA hallmark of tissue ageing is the irreversible oxidative modification of its proteins. We show that single proteins, kept unfolded and extended by a mechanical force, undergo accelerated ageing in times scales of minutes to days. A protein forced to be continuously unfolded completely loses its ability to contract by folding, becoming a labile
Jessica Valle‐Orero, Jaime Andrés Rivas‐Pardo, Rafael Tapia‐Rojo, Ionel Popa, Daniel J. Echelman, Shubhasis Haldar, Julio M. Fernández   +6 more
openaire   +4 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source