Results 31 to 40 of about 511,853 (298)

Metal mixtures and DNA methylation measures of biological aging in American Indian populations

Environment International, 2023
Introduction: Native American communities suffer disproportionately from elevated metal exposures and increased risk for cardiovascular diseases and diabetes. DNA methylation is a sensitive biomarker of aging-related processes and novel epigenetic-based “
Kaila Boyer, Arce Domingo-Relloso, Enoch Jiang, Karin Haack, Walter Goessler, Ying Zhang, Jason G. Umans, Daniel W. Belsky, Shelley A. Cole, Ana Navas-Acien, Allison Kupsco   +10 more
doaj   +1 more source

Age-Related Human Adaptation to Extreme Climatic Factors and Environmental Conditions

Biology
The exposome, which encompasses lifetime environmental exposures, significantly impacts health and can act as a major driving force in accelerating the aging process.
Anna E. Kallio, Ekaterina A. Davydova, Tatiana A. Mishchenko, Tatiana M. Sivtseva, Maria M. Nikolaeva, Dmitriy E. Burmistrov, Anzhela D. Bolshakova, Sergey N. Tsybusov, Raisa N. Zakharova, Maria V. Vedunova   +9 more
doaj   +1 more source

Investigating the Relationship between Epigenetic Age and Cardiovascular Risk in a Population with Overweight/Obesity

Biomedicines
Introduction: Cardiovascular diseases stand as the leading global cause of mortality. Major modifiable risk factors encompass overweight/obese conditions, high blood pressure, elevated LDL cholesterol, diabetes, smoking, secondhand smoke exposure ...
Davide Marinello, Chiara Favero, Benedetta Albetti, Davide Barbuto, Luisella Vigna, Angela Cecilia Pesatori, Valentina Bollati, Luca Ferrari   +7 more
doaj   +1 more source

Biological Ageing Acceleration and Functional Capacities Across the Lifespan in the INSPIRE‐T Cohort

Journal of Cachexia, Sarcopenia and Muscle
Background Biological clocks are promising tools for the evaluation of biological age deviations (i.e., positive/negative acceleration). Here, we explored the associations of biological age acceleration (BAA) assessed by Horvath's, Hannum's, PhenoAge ...
Juan Luis Sánchez‐Sánchez, Bruno Vellas, Sophie Guyonnet, Paul Bensadoun, Jean‐Marc Lemaitre, Matias Fuentealba Valenzuela, Fabien Pillard, Yves Rolland, David Furman, Philipe deSouto Barreto   +9 more
doaj   +1 more source

ON RADIATION-INDUCED AGING: ACCELERATED OR PREMATURE AGING

Radiation Protection Dosimetry, 2022
Abstract The concept of radiation-induced aging is revisited from the viewpoint of a mathematical model. The effect of radiation on carcinogenesis is treated based on the Armitage–Doll multi-stage theory. The formula obtained for cancer incidence rate indicates that radiation dose can be explained in terms of time.
Takahiro Wada, Tetsuhiro Kinugawa, Satoshi Tanaka   +2 more
openaire   +2 more sources

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Biological Aging and Chemotoxicity in Patients with Colorectal Cancer: A Secondary Data Analysis Using EHR Data

Current Oncology
Background: Biological aging influences cancer outcomes, but its changes during chemotherapy and impact on chemotoxicity in colorectal cancer (CRC) remain underinvestigated.
Claire J. Han, Ashley E. Rosko, Jesse J. Plascak, Alai Tan, Anne M. Noonan, Christin E. Burd   +5 more
doaj   +1 more source

Adiabatic decaying vacuum model for the universe

, 2003
We study a model that the entropy per particle in the universe is constant. The sources for the entropy are the particle creation and a lambda decaying term.
A. G. Riess, E. Carreta, G. Gamov, H. R. Butcher, J. A. Belinchon, J. A. S. Lima, J. A. S. Lima, J. C. Carvalho, J. Westin, L. M. Krauss, L. R. Abramo, M. de Campos, M. de Campos, M. O. Calvão, S. Carroll, S. Perlmutter, S. Weinberg, T. Harko, V. Sahni, W. Chu, Y. Prigogine   +20 more
core   +1 more source

Cosmic Ray Acceleration in Superbubbles and the Composition of Cosmic Rays [PDF]

, 2000
We review the evidence for cosmic ray acceleration in the superbubble/hot phase of the interstellar medium, and discuss the implications for the composition of cosmic rays and the structure and evolution of the interstellar medium.
Higdon, J. C., Lingenfelter, R. E., Ramaty, R.   +2 more
core   +3 more sources

Pulmonary Dysfunction Is Associated With Sleep Study Abnormalities in Children With Sickle Cell Disease: A Multicenter Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Pulmonary dysfunction and sleep abnormalities are common in children with sickle cell disease (SCD) and are associated with worse clinical outcomes. Whether spirometry abnormalities are associated with polysomnography (PSG) findings remains unclear.
Ammar Saadoon Alishlash, Anis Rabbani Nourani, A. K. M. Fazlur Rahman, Dima Ezmigna, Tarig Ali‐Dinar   +4 more
wiley   +1 more source