Results 41 to 50 of about 511,853 (298)

Gender disparities in marital status and risk of developing age acceleration: Findings from NHANES 2015–2018

Experimental Gerontology
Background: Marriage has been a hot topic since ancient times forever, yet there is little research evidence on marital status as an important socio-behavioral factor in relation to aging.
Jialu Wang, Feixiang Xu, Yin Wang, Lizhan Bie   +3 more
doaj   +1 more source

Epigenetic age acceleration and clinical outcomes in gliomas.

PLoS ONE, 2020
Epigenetic age acceleration-the difference between an individual's DNA methylation age and chronological age-is associated with many diseases including cancer. This study aims to evaluate epigenetic age acceleration as a prognostic biomarker for gliomas.
Chunlei Zheng, Nathan A Berger, Li Li, Rong Xu   +3 more
doaj   +1 more source

Methylation signatures in peripheral blood are associated with marked age acceleration and disease progression in patients with primary sclerosing cholangitis

JHEP Reports, 2020
Background & Aims: A DNA methylation (DNAm) signature derived from 353 CpG sites (the Horvath clock) has been proposed as an epigenetic measure of chronological and biological age.
Michael Trauner, Yevgeniy Gindin, Zhaoshi Jiang, Chuhan Chung, G. Mani Subramanian, Robert P. Myers, Aliya Gulamhusein, Kris V. Kowdley, Cynthia Levy, Zachary Goodman, Michael P. Manns, Andrew J. Muir, Christopher L. Bowlus   +12 more
doaj   +1 more source

Magnetic Field Amplification in Tycho and other Shell-type Supernova Remnants

, 2004
It is shown that amplification of the magnetic field in supernova remnants (SNRs) occurs in all six objects where morphological measurements are presently available in the hard X-ray continuum at several keV.
Achterberg, Aharonian, Aharonian, Aharonian, Axford, Bamba, Bamba, Bell, Bell, Bell, Berezhko, Berezhko, Berezhko, Berezhko, Berezhko, Blandford, Blandford, Borkowski, Buckley, Cassam-Chenaï, DeLaney, Dickel, E. G. Berezhko, Ellison, Enomoto, Fukui, H. J. Völk, Hwang, Katz-Stone, Koyama, Ksenofontov, L. T. Ksenofontov, Lazendic, Long, Lucek, Mastichiadis, McKenzie, Muraishi, Pannuti, Pohl, Reynolds, Reynoso, Reynoso, Reynoso, Rho, Rosado, Tanimori, Uchiyama, Vink, Völk, Völk, Völk, Völk   +52 more
core   +1 more source

The Long-Term Future of Extragalactic Astronomy [PDF]

, 2001
If the current energy density of the universe is indeed dominated by a cosmological constant, then high-redshift sources will remain visible to us only until they reach some finite age in their rest-frame. The radiation emitted beyond that age will never
A. Riess, A.A. Starobinsky, Abraham Loeb, B. Ratra, D. Edwards, D. Edwards, E. Harrison, F.C. Adams, G. Starkman, G.F. Ellis, J.D. Barrow, L.M. Krauss, M.P. Dabrowaki, M.P. Dabrowaki, P. de Bernardis, P.M. Garnavich, R.R. Caldwell, S. Hanany, S. Perlmutter, S. Weinberg, T. Rothman, U. Pen, W. Rindler   +22 more
core   +4 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Differential DNA methylation clock ages across buffy coat (BC), peripheral blood mononuclear cells (PBMC), and saliva in individuals in early-to-mid adulthood

Epigenetics
Epigenetic aging prior to midlife is gaining interest as an intervenable period to address health and cognitive aging. Epigenetic changes may index DNA methylation aging rates, but methylation profiles may not be substitutable across tissues. We compared
Ryan Bruellman, Donald Evans, Andrew Smolen, Luke M. Evans, Chandra A. Reynolds   +4 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The early-life exposome and epigenetic age acceleration in children

Environment International, 2021
The early-life exposome influences future health and accelerated biological aging has been proposed as one of the underlying biological mechanisms. We investigated the association between more than 100 exposures assessed during pregnancy and in childhood
Paula de Prado-Bert, Carlos Ruiz-Arenas, Marta Vives-Usano, Sandra Andrusaityte, Solène Cadiou, Ángel Carracedo, Maribel Casas, Leda Chatzi, Payam Dadvand, Juan R. González, Regina Grazuleviciene, Kristine B. Gutzkow, Line S. Haug, Carles Hernandez-Ferrer, Hector C. Keun, Johanna Lepeule, Léa Maitre, Rosie McEachan, Mark J. Nieuwenhuijsen, Dolors Pelegrí, Oliver Robinson, Rémy Slama, Marina Vafeiadi, Jordi Sunyer, Martine Vrijheid, Mariona Bustamante   +25 more
doaj   +1 more source

Probing the course of cosmic expansion with a combination of observational data

, 2010
We study the cosmic expansion history by reconstructing the deceleration parameter $q(z)$ from the SDSS-II type Ia supernova sample (SNIa) with two different light curve fits (MLCS2k2 and SALT-II), the baryon acoustic oscillation (BAO) distance ratio ...
A. Vikhlinin ., A.C.C. Guimarães, E. Komatsu ., E. Rozo ., ESSENCE collaboration, G.R. Bengochea, Hongwei Yu, J.A. Frieman ., J.C.B. Sanchez, M. Hicken ., Puxun Wu, R. Kessler ., R. Lazkoz, S. Jha, S. Nesseris, SDSS collaboration, Supernova Cosmology Project collaboration, Supernova Search Team collaboration, Supernova Search Team collaboration, U. Alam, WMAP collaboration, WMAP collaboration, Y. Gong, Y. Gong, Y. Wang, Zhengxiang Li   +25 more
core   +1 more source