Results 21 to 30 of about 5,559,088 (293)

Sirtuins and Accelerated Aging in Scleroderma [PDF]

Current Rheumatology Reports, 2018
Premature activation of aging-associated molecular mechanisms is emerging as an important contributor to many diseases, including scleroderma. Among central regulators of the aging process are a group of histone deacetylases called sirtuins (SIRTs). Recent findings implicate these molecules as pathophysiological players in scleroderma skin and lung ...
Anne E, Wyman, Sergei P, Atamas
openaire   +2 more sources

Epigenetic Age Acceleration and Hearing: Observations From the Baltimore Longitudinal Study of Aging

Frontiers in Aging Neuroscience, 2021
Objectives: Age-related hearing loss (ARHL) is highly prevalent among older adults, but the potential mechanisms and predictive markers for ARHL are lacking.
Pei-Lun Kuo, Ann Zenobia Moore, Frank R. Lin, Frank R. Lin, Luigi Ferrucci   +4 more
doaj   +1 more source

Menopause accelerates biological aging [PDF]

Proceedings of the National Academy of Sciences, 2016
Significance Within an evolutionary framework, aging and reproduction are intrinsically linked. Although both laboratory and epidemiological studies have observed associations between the timing of reproductive senescence and longevity, it is not yet known whether differences in the age of menopause are reflected in biomarkers of ...
Levine, Morgan E, Lu, Ake T, Chen, Brian H, Hernandez, Dena G, Singleton, Andrew B, Ferrucci, Luigi, Bandinelli, Stefania, Salfati, Elias, Manson, JoAnn E, Quach, Austin, Kusters, Cynthia DJ, Kuh, Diana, Wong, Andrew, Teschendorff, Andrew E, Widschwendter, Martin, Ritz, Beate R, Absher, Devin, Assimes, Themistocles L, Horvath, Steve   +18 more
openaire   +5 more sources

Associations Between Blood Pressure and Accelerated DNA Methylation Aging

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Individuals of the same chronological age may exhibit diverse susceptibilities to death. However, few studies have investigated the associations between blood pressure and the accelerated aging.
Lili Xiao, Gaohui Zan, Chaoqun Liu, Xia Xu, Longman Li, Xing Chen, Zhiyong Zhang, Xiaobo Yang   +7 more
doaj   +1 more source

Failure of immunosurveillance accelerates aging [PDF]

OncoImmunology, 2019
Immunosurveillance is generally conceived as a mechanism through which the immune system detects and eliminates (pre-)malignant cells, thus reducing the risk of developing cancer. A recent paper by Ovadya et al. demonstrates that knockout of the gene coding for perforin-1 causes accelerated accumulation of senescent cells in multiple mouse organs ...
Maria Perez-Lanzon, Laurence Zitvogel, Guido Kroemer   +2 more
openaire   +4 more sources

Metal mixtures and DNA methylation measures of biological aging in American Indian populations

Environment International, 2023
Introduction: Native American communities suffer disproportionately from elevated metal exposures and increased risk for cardiovascular diseases and diabetes. DNA methylation is a sensitive biomarker of aging-related processes and novel epigenetic-based “
Kaila Boyer, Arce Domingo-Relloso, Enoch Jiang, Karin Haack, Walter Goessler, Ying Zhang, Jason G. Umans, Daniel W. Belsky, Shelley A. Cole, Ana Navas-Acien, Allison Kupsco   +10 more
doaj   +1 more source

Acceleration in turbulent channel flow

, 2010
We use Direct Numerical Simulations of turbulent channel flow to study the acceleration A corresponding to the full fluid velocity u and the acceleration a corresponding to the fluctuating velocity u? ? u?hui where hui is the mean flow.
S. W. Coleman, Z. Hu, Chen, L., Vassilicos, J.C., L. Chen, Hu, Zhiwei, Coleman, S.W., J. C. Vassilicos   +7 more
core   +1 more source

Age-Related Human Adaptation to Extreme Climatic Factors and Environmental Conditions

Biology
The exposome, which encompasses lifetime environmental exposures, significantly impacts health and can act as a major driving force in accelerating the aging process.
Anna E. Kallio, Ekaterina A. Davydova, Tatiana A. Mishchenko, Tatiana M. Sivtseva, Maria M. Nikolaeva, Dmitriy E. Burmistrov, Anzhela D. Bolshakova, Sergey N. Tsybusov, Raisa N. Zakharova, Maria V. Vedunova   +9 more
doaj   +1 more source

DNA Methylation Algorithms of Aging and Incident Cardiovascular Disease: A Prospective Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background While DNA methylation (DNAm)‐based algorithms of aging show promise for predicting age‐related diseases, their comparative utility for incident cardiovascular disease (CVD) remains underexplored.
Xian Cui, Chunbei Yi, Hui Zhang, Yaqian Xu, Chongyu Ding, Zhaojun Wang, Shiqun Sun, Xiangwei Li   +7 more
doaj   +1 more source

Photon acceleration by laser produced wakefields on Astra [PDF]

, 2004
This chapter looks at photon acceleration by laser produced wakefields on ...
Thomas, A.G.R., Trines, Raoul M. G. M., Mangles, S.P.D., Norreys, P.A., Bingham, Robert, Divall, E.J., Najmudin, Z, Foster, P.S., Langley, A.J., Collier, J.L., Hooker, C.J., Viskup, Richard, Jaroszynski, Dino, Reitsma, Albert, Gallacher, J. G., Krushelnick, K., Murphy, C.D., Smith, J,M.   +17 more
core   +4 more sources