Results 1 to 10 of about 511,853 (298)

Menopause accelerates biological aging [PDF]

Proceedings of the National Academy of Sciences, 2016
Although epigenetic processes have been linked to aging and disease in other systems, it is not yet known whether they relate to reproductive aging. Recently, we developed a highly accurate epigenetic biomarker of age (known as the “epigenetic clock ...
Absher, D, Assimes, TL, Bandinelli, S, Chen, BH, Ferrucci, L, Hernandez, DG, Horvath, S, Kuh, D, Kusters, CDJ, Levine, ME, Lu, AT, Manson, JE, Quach, A, Ritz, BR, Salfati, E, Singleton, AB, Teschendorff, AE, Widschwendter, M, Wong, A   +18 more
core   +7 more sources

Epigenetic age acceleration in peripheral blood correlates with brain-MRI age acceleration. [PDF]

Brain
Abstract As the world’s population ages, more and more people are expected to suffer from age-related diseases. Biological ageing markers derived from DNA methylation and brain structure show promise in predicting health outcomes. Understanding the relationship between these biomarkers can promote the development of effective health ...
Sant'Anna Barbosa Ferreira P, van Dongen J, den Braber A, Boomsma DI, de Geus EJC, van 't Ent D.   +5 more
europepmc   +4 more sources

Investigating Transcriptional Age Acceleration in Inflammatory Skin Diseases [PDF]

JID Innovations
Epigenetic age acceleration has previously been observed in inflammatory skin disease; however, less is known regarding recently described age-related gene expression patterns (“transcriptional clocks”). We investigated the role of transcriptional clocks
Richie Jeremian, Melissa Galati, Rayyan Fotovati, Kaiyang Li, Carolyn Jack, David O. Croitoru, Stephan Caucheteux, Philippe Lefrançois, Vincent Piguet   +8 more
doaj   +2 more sources

Prenatal and birth associations of epigenetic gestational age acceleration in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) cohort

Epigenetics, 2022
Gestational age (GA) is an important determinant of child health and disease risk. Two epigenetic GA clocks have been developed using DNA methylation (DNAm) patterns in cord blood.
Saher Daredia, Karen Huen, Lars Van Der Laan, Philip A. Collender, Jamaji C. Nwanaji-Enwerem, Kim Harley, Julianna Deardorff, Brenda Eskenazi, Nina Holland, Andres Cardenas   +9 more
doaj   +1 more source

Epigenetic Age Acceleration in Mothers and Offspring 4–10 Years after a Pregnancy Complicated by Gestational Diabetes and Obesity

Metabolites, 2022
A known association exists between exposure to gestational diabetes mellitus (GDM) and epigenetic age acceleration (EAA) in GDM-exposed offspring compared to those without GDM exposure.
Nita Kanney, Amit Patki, Paula Chandler-Laney, W. Timothy Garvey, Bertha A. Hidalgo   +4 more
doaj   +1 more source

Comparative validation of three DNA methylation algorithms of ageing and a frailty index in relation to mortality: results from the ESTHER cohort study

EBioMedicine, 2021
Background: Three DNA methylation (DNAm) based algorithms, DNAm PhenoAge acceleration (AgeAccelPheno), DNAm GrimAge acceleration (AgeAccelGrim), and mortality risk score (MRscore), based on methylation in 513, 1030, and 10 CpGs, respectively, were ...
Xiangwei Li, Yan Zhang, Xīn Gào, Bernd Holleczek, Ben Schöttker, Hermann Brenner   +5 more
doaj   +1 more source

Novel Zinc-Related Differentially Methylated Regions in Leukocytes of Women With and Without Obesity

Frontiers in Nutrition, 2022
IntroductionNutriepigenetic markers are predictive responses associated with changes in “surrounding” environmental conditions of humans, which may influence metabolic diseases. Although rich in calories, Western diets could be linked with the deficiency
Natália Yumi Noronha, Mariana Barato, Chanachai Sae-Lee, Marcela Augusta de Souza Pinhel, Marcela Augusta de Souza Pinhel, Lígia Moriguchi Watanabe, Vanessa Aparecida Batista Pereira, Guilherme da Silva Rodrigues, Déborah Araújo Morais, Wellington Tavares de Sousa, Vanessa Cristina de Oliveira Souza, Jessica Rodrigues Plaça, Wilson Salgado, Fernando Barbosa, Torsten Plösch, Carla Barbosa Nonino, Carla Barbosa Nonino   +16 more
doaj   +1 more source

DNA Methylation-Based Age Prediction and Telomere Length Reveal an Accelerated Aging in Induced Sputum Cells Compared to Blood Leukocytes: A Pilot Study in COPD Patients

Frontiers in Medicine, 2021
Aging is the predominant risk factor for most degenerative diseases, including chronic obstructive pulmonary disease (COPD). This process is however very heterogeneous.
Manuela Campisi, Filippo Liviero, Piero Maestrelli, Gabriella Guarnieri, Sofia Pavanello   +4 more
doaj   +1 more source

DNA Methylation - and Telomere - Based Biological Age Estimation as Markers of Biological Aging in Donors Kidneys

Frontiers in Medicine, 2022
The biological age of an organ may represent a valuable tool for assessing its quality, especially in the elder. We examined the biological age of the kidneys [right (RK) and left kidney (LK)] and blood leukocytes in the same subject and compared these ...
Sofia Pavanello, Manuela Campisi, Paolo Rigotti, Marianna Di Bello, Erica Nuzzolese, Flavia Neri, Lucrezia Furian   +6 more
doaj   +1 more source

Novel Epigenetic Clock Biomarkers of Age-Related Macular Degeneration

Frontiers in Medicine, 2022
Age-Related Macular Degeneration (AMD) is a bilateral ocular condition resulting in irreversible vision impairment caused by the progressive loss of photoreceptors in the macula, a region at the center of the retina. The progressive loss of photoreceptor
Saurav Mallik, Fran Grodstein, David A. Bennett, Demetrios G. Vavvas, Bernardo Lemos, Bernardo Lemos   +5 more
doaj   +1 more source