Results 11 to 20 of about 511,853 (298)

Associations between medium- and long-term exposure to air temperature and epigenetic age acceleration

Environment International, 2023
Climate change poses a serious threat to human health worldwide, while aging populations increase. However, no study has ever investigated the effects of air temperature on epigenetic age acceleration.
Wenli Ni, Nikolaos Nikolaou, Cavin K. Ward-Caviness, Susanne Breitner, Kathrin Wolf, Siqi Zhang, Rory Wilson, Melanie Waldenberger, Annette Peters, Alexandra Schneider   +9 more
doaj   +3 more sources

Association between sleep disordered breathing and epigenetic age acceleration: Evidence from the Multi-Ethnic Study of Atherosclerosis

EBioMedicine, 2019
Background: Sleep disordered breathing (SDB) is a common disorder that results in oxidative stress and inflammation and is associated with multiple age-related health outcomes.
Xiaoyu Li, Roby Joehanes, Ina Hoeschele, Stephen S. Rich, Jerome I. Rotter, Daniel Levy, Yongmei Liu, Susan Redline, Tamar Sofer   +8 more
doaj   +3 more sources

Systematic underestimation of the epigenetic clock and age acceleration in older subjects

Genome Biology, 2019
Background The Horvath epigenetic clock is widely used. It predicts age quite well from 353 CpG sites in the DNA methylation profile in unknown samples and has been used to calculate “age acceleration” in various tissues and environments.
Louis Y. El Khoury, Tyler Gorrie-Stone, Melissa Smart, Amanda Hughes, Yanchun Bao, Alexandria Andrayas, Joe Burrage, Eilis Hannon, Meena Kumari, Jonathan Mill, Leonard C. Schalkwyk   +10 more
doaj   +2 more sources

Mitochondrial Dysfunction Accelerates Ageing

Immunometabolism, 2020
Abstract We review here the seminal findings of Desdin-Mico et al. showing that T cells with dysfunctional mitochondria induce multimorbity and premature senescence, due to mitochondrial transcription factor A (TFAM). They add further weight to the idea that targeting immunometabolism could be beneficial in combating the ...
Schroth, J, Henson, SM
openaire   +3 more sources

The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936 [PDF]

, 2015
Background: The DNA methylation-based 'epigenetic clock' correlates strongly with chronological age, but it is currently unclear what drives individual differences. We examine cross-sectional and longitudinal associations between the epigenetic clock and
Corley, Janie, Cox, Simon R, Deary, Ian J, Gibson, Jude, Harris, Sarah E, Horvath, Steve, Marioni, Riccardo E, McRae, Allan F, Muniz-Terrera, Graciela, Murphy, Lee, Pattie, Alison, Redmond, Paul, Ritchie, Stuart J, Shah, Sonia, Starr, John M, Taylor, Adele, Visscher, Peter M, Wray, Naomi R   +17 more
core   +1 more source

Evaluation of Epigenetic Age Acceleration Scores and Their Associations with CVD-Related Phenotypes in a Population Cohort

Biology, 2022
We evaluated associations between nine epigenetic age acceleration (EAA) scores and 18 cardiometabolic phenotypes using an Eastern European ageing population cohort richly annotated for a diverse set of phenotypes (subsample, n = 306; aged 45–69 years ...
Olga Chervova, Elizabeth Chernysheva , Kseniia Panteleeva , Tyas Arum Widayati , Natalie Hrbkova, Jadesada Schneider , Vladimir Maximov , Andrew Ryabikov , Taavi Tillmann , Hynek Pikhart, Martin Bobak , Vitaly Voloshin , Sofia Malyutina , Stephan Beck    +13 more
doaj   +1 more source

Methylation age acceleration does not predict mortality in schizophrenia. [PDF]

, 2019
Schizophrenia (SCZ) is associated with high mortality. DNA methylation levels vary over the life course, and pre-selected combinations of methylation array probes can be used to estimate "methylation age" (mAge). mAge correlates highly with chronological
Burrage, Joe, Hannon, Eilis, Kowalec, Kaarina, Mansell, Georgina, Mill, Jonathan, Ophoff, Roel A, Ori, Anil PS, Sullivan, Patrick F   +7 more
core   +1 more source

Accelerated epigenetic age at birth and child emotional and behavioura development in early childhood: a meta-analysis of four prospective cohort studies in ECHO

Epigenetics, 2023
Background: ‘Epigenetic clocks’ have been developed to accurately predict chronologic gestational age and have been associated with child health outcomes in prior work. Methods: We meta-analysed results from four prospective U.S cohorts investigating the
Ashley Y. Song, Catherine M. Bulka, Sierra S. Niemiec, Katerina Kechris, Kristen E. Boyle, Carmen J. Marsit, T. Michael O’Shea, Rebecca C. Fry, Kristen Lyall, M. Daniele Fallin, Heather E. Volk, Christine Ladd-Acosta   +11 more
doaj   +1 more source

Exploring the Relationship of Relative Telomere Length and the Epigenetic Clock in the LipidCardio Cohort [PDF]

, 2019
Telomere length has been accepted widely as a biomarker of aging. Recently, a novel candidate biomarker has been suggested to predict an individual’s chronological age with high accuracy: The epigenetic clock is based on the weighted DNA methylation ...
Banszerus, Verena L., Demuth, Ilja, König, Maximilian, Salewsky, Bastian, Vetter, Valentin M.   +4 more
core   +1 more source

Linking gamma-ray spectra of supernova remnants to the cosmic ray injection properties in the aftermath of supernovae [PDF]

, 2017
The acceleration times of the highest-energy particles which emit gamma-rays in young and middle-age SNRs are comparable with SNR age. If the number of particles starting acceleration was varying during early times after the supernova explosion then this
Bocchino, F., Miceli, M., Orlando, S., Petruk, O.   +3 more
core   +2 more sources