Results 71 to 80 of about 511,853 (298)
Epigenetics, 2023 Epigenetic age acceleration is a risk factor for chronic diseases of ageing and may reflect aspects of biological ageing. However, few studies have examined epigenetic ageing during the early neonatal period in preterm infants, who are at heightened risk
Uriel Paniagua +15 more
doaj +1 more source
DNA methylation-based age prediction and telomere length in white blood cells and cumulus cells of infertile women with normal or poor response to ovarian stimulation. [PDF]
, 2018 An algorithm assessing the methylation levels of 353 informative CpG sites in the human genome permits accurate prediction of the chronologic age of a subject.
Bedard, Jenna +7 more
core +1 more source
Evolution of High-Energy Particle Distribution in Mature Shell-Type Supernova Remnants
, 2016 Multi-wavelength observations of mature supernova remnants (SNRs), especially with recent advances in gamma-ray astronomy, make it possible to constrain energy distribution of energetic particles within these remnants.
Jokipii, J. R. +5 more
core +1 more source
Accelerated epigenetic aging in Werner syndrome. [PDF]
, 2017 Individuals suffering from Werner syndrome (WS) exhibit many clinical signs of accelerated aging. While the underlying constitutional mutation leads to accelerated rates of DNA damage, it is not yet known whether WS is also associated with an increased ...
Flunkert, Julia +5 more
core +1 more source
Obesity accelerates cardiovascular ageing
European Heart JournalAbstract A global obesity pandemic, coupled with an increasingly ageing population, is exacerbating the burden of cardiovascular disease. Indeed, clinical and experimental evidence underscores a potential connection between obesity and ageing in the pathogenesis of various cardiovascular disorders. This is further supported by the notion
Ruperez, Celia +4 more
openaire +3 more sources
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Gamma-ray production in young open clusters: Berk 87, Cyg OB2 and Westerlund 2
, 2007 Young open clusters are likely sites of cosmic ray acceleration as indicated by recent detections of the TeV gamma-ray sources in the directions of two open clusters (Cyg OB2 and Westerlund 2) and their directional proximity to some unidentified EGRET ...
Bednarek, W.
core +1 more source
Constraints On the Diffusive Shock Acceleration From the Nonthermal X-ray Thin Shells In SN1006 NE Rim [PDF]
, 2003 Characteristic scale lengths of nonthermal X-rays from the SN1006 NE rim, which are observed by Chandra, are interpreted in the context of the diffusive shock acceleration on the assumption that the observed spatial profile of nonthermal X-rays ...
A. Bamba +28 more
core +3 more sources
Cytomegalovirus infection accelerates epigenetic aging
Experimental Gerontology, 2015 Epigenetic mechanisms such as DNA methylation (DNAm) have a central role in the regulation of gene expression and thereby in cellular differentiation and tissue homeostasis. It has recently been shown that aging is associated with profound changes in DNAm. Several of these methylation changes take place in a clock-like fashion, i.e.
Jylhava Juulia +7 more
openaire +2 more sources
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source