Structure and function of aggrecan [PDF]
Cell Research, 2002 Aggrecan is the major proteoglycan in the articular cartilage. This molecule is important in the proper functioning of articular cartilage because it provides a hydrated gel structure (via its interaction with hyaluronan and link protein) that endows the cartilage with load-bearing properties.
Chris, Kiani +4 more
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Lateral Nanomechanics of Cartilage Aggrecan Macromolecules [PDF]
Biophysical Journal, 2006 To explore the role of the brush-like proteoglycan, aggrecan, in the shear behavior of cartilage tissue, we measured the lateral resistance to deformation of a monolayer of chemically end-attached cartilage aggrecan on a microcontact printed surface in aqueous NaCl solutions via lateral force microscopy.
Lin Han +3 more
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Aggrecan structure in amphibian cartilage [PDF]
Brazilian Journal of Medical and Biological Research, 2000 The structure of the large proteoglycan present in the bullfrog epiphyseal cartilage was studied by immunochemical and biochemical methods. The isolated monomer showed a polydisperse behavior on Sepharose CL2B, with a peak at Kav = 0.14. Chondroitin sulfate chains were identified by HPLC analysis of the products formed by chondroitinase digestion and ...
Covizi D.Z., Carvalho H.F.
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Intervertebral Disc Proteoglycans: Multifunctional Tissue Stabilizing and Instructional Cell Regulatory Proteins That Control Tissue Homeostasis [PDF]
JOR SpineThe intervertebral disc (IVD) is a tough fibrocartilaginous viscoelastic cushion interposed between spinal vertebrae. It has a composite structure whose material properties are due to the interplay between fibrillar collagens which, provide high tensile ...
James Melrose
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The involvement of aggrecan polymorphism in degeneration of human intervertebral disc and articular cartilage [PDF]
European Cells & Materials, 2006 The functions of the intervertebral disc and of articular cartilage are intimately related to their aggrecan content. Aggrecan is a proteoglycan that interacts with hyaluronan to form large aggregates, which are responsible for the ability of the tissues
P Roughley +5 more
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Wogonin pretreatment of infrapatellar fat pad mesenchymal stem cell-derived exosomes advances articular cartilage repair in osteoarthritis [PDF]
Bone & Joint ResearchAims: Osteoarthritis (OA) is a chronic joint disorder characterized by progressive cartilage degeneration, inflammation, and subchondral bone remodelling.
Wenzhao Li +3 more
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Time-dependent computational model of post-traumatic osteoarthritis to estimate how mechanoinflammatory mechanisms impact cartilage aggrecan content. [PDF]
PLoS Computational BiologyDegenerative musculoskeletal diseases like osteoarthritis can be initiated by joint injury. Injurious overloading-induced mechanical straining of articular cartilage and subsequent biological responses may trigger cartilage degradation. One early sign of
Atte S A Eskelinen +7 more
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Self-Consistent Field Modeling of Bottle-Brush with Aggrecan-like Side Chain [PDF]
BiomimeticsBottle-brush polymers with aggrecan-like side chains represent a class of biomimetic macromolecules that replicate key structural and functional features of natural complexes of aggrecans with hyaluronic acid (HA) which are the major components of ...
Ivan V. Mikhailov +3 more
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