Results 11 to 20 of about 29,689 (270)

Synovial mesenchymal progenitor derived aggrecan regulates cartilage homeostasis and endogenous repair capacity

Cell Death and Disease, 2022
Aggrecan is a critical component of the extracellular matrix of all cartilages. One of the early hallmarks of osteoarthritis (OA) is the loss of aggrecan from articular cartilage followed by degeneration of the tissue.
Roman J. Krawetz, Yiru Elizabeth Wu, Karri L. Bertram, Anchita Shonak, Anand O. Masson, Guomin Ren, Catherine Leonard, Mohit Kapoor, John R. Matyas, Paul T. Salo   +9 more
doaj   +2 more sources

Aggrecan in Cardiovascular Development and Disease [PDF]

Journal of Histochemistry & Cytochemistry, 2020
Aggrecan is a large proteoglycan that forms giant hydrated aggregates with hyaluronan in the extracellular matrix (ECM). The extraordinary resistance of these aggregates to compression explains their abundance in articular cartilage of joints where they ensure adequate load-bearing.
Christopher D, Koch, Chan Mi, Lee, Suneel S, Apte   +2 more
openaire   +3 more sources

Aggrecan, the Primary Weight-Bearing Cartilage Proteoglycan, Has Context-Dependent, Cell-Directive Properties in Embryonic Development and Neurogenesis: Aggrecan Glycan Side Chain Modifications Convey Interactive Biodiversity

Biomolecules, 2020
This review examines aggrecan’s roles in developmental embryonic tissues, in tissues undergoing morphogenetic transition and in mature weight-bearing tissues.
Anthony J Hayes, James Melrose
doaj   +2 more sources

Aggrecan Directs Extracellular Matrix-Mediated Neuronal Plasticity [PDF]

The Journal of Neuroscience, 2018
In the adult brain, the extracellular matrix (ECM) influences recovery after injury, susceptibility to mental disorders, and is in general a strong regulator of neuronal plasticity. The proteoglycan aggrecan is a core component of the condensed ECM structures termed perineuronal nets (PNNs), and the specific role of PNNs on neural plasticity remains ...
Daire Rowlands, Kristian K. Lensjø, Tovy Dinh, Sujeong Yang, Melissa R. Andrews, Torkel Hafting, Marianne Fyhn, James W. Fawcett, Gunnar Dick   +8 more
openaire   +5 more sources

Juvenile Hippocampal CA2 Region Expresses Aggrecan [PDF]

Frontiers in Neuroanatomy, 2017
Perineuronal nets (PNNs) are distributed primarily around inhibitory interneurons in the hippocampus, such as parvalbumin-positive interneurons. PNNs are also present around excitatory neurons in some brain regions and prevent plasticity in these neurons.
Asako Noguchi, Nobuyoshi Matsumoto, Shota Morikawa, Hideki Tamura, Yuji Ikegaya, Yuji Ikegaya   +5 more
openaire   +4 more sources

The role of aggrecan in normal and osteoarthritic cartilage

Journal of Experimental Orthopaedics, 2014
Aggrecan is a large proteoglycan bearing numerous chondroitin sulfate and keratan sulfate chains that endow articular cartilage with its ability to withstand compressive loads.
Peter J Roughley, John S Mort
doaj   +2 more sources

Aggrecan and COMP Improve Periosteal Chondrogenesis by Delaying Chondrocyte Hypertrophic Maturation

Frontiers in Bioengineering and Biotechnology, 2020
The generation of cartilage from progenitor cells for the purpose of cartilage repair is often hampered by hypertrophic differentiation of the engineered cartilaginous tissue caused by endochondral ossification.
Marjolein M. J. Caron, Maarten P. F. Janssen, Laura Peeters, Dominik R. Haudenschild, Andy Cremers, Don A. M. Surtel, Lodewijk W. van Rhijn, Pieter J. Emans, Tim J. M. Welting   +8 more
doaj   +2 more sources

The bioactivity of agarose–PEGDA interpenetrating network hydrogels with covalently immobilized RGD peptides and physically entrapped aggrecan

Biomaterials, 2014
Ganesh C Ingavle, Stevin H Gehrke, Michael S Detamore   +2 more
exaly   +3 more sources

Novel missense ACAN gene variants linked to familial osteochondritis dissecans cluster in the C-terminal globular domain of aggrecan

Scientific Reports, 2022
The cartilage aggrecan proteoglycan is crucial for both skeletal growth and articular cartilage function. A number of aggrecan (ACAN) gene variants have been linked to skeletal disorders, ranging from short stature to severe chondrodyplasias ...
E. Stattin, K. Lindblom, A. Struglics, P. Önnerfjord, J. Goldblatt, A. Dixit, A. Sarkar, T. Randell, M. Suri, C. Raggio, Jessica Davis, E. Carter, A. Aspberg   +12 more
semanticscholar   +1 more source

Blood and urine biomarkers in osteoarthritis – an update on cartilage associated type II collagen and aggrecan markers

Current Opinion in Rheumatology, 2021
Purpose of review Osteoarthritis (OA) is a painful disease for which drug development has proven difficult. One major reason for this is the heterogeneity of the disease and the current lack of operationalized means to distinguish various disease ...
A. Bay‐Jensen, A. Mobasheri, C. Thudium, V. Kraus, M. Karsdal   +4 more
semanticscholar   +1 more source