Results 21 to 30 of about 29,689 (270)

Aggrecan governs intervertebral discs development by providing critical mechanical cues of the extracellular matrix

Frontiers in Bioengineering and Biotechnology, 2023
Aggrecan (ACAN) is localized in the intervertebral disc (IVD) in unique compartment-specific patterns where it contributes to the tissue structure and mechanical function together with collagens.
Marta Empere, Marta Empere, Xujia Wang, Carina Prein, Carina Prein, Anders Aspberg, Markus Moser, Markus Moser, Toshitaka Oohashi, Hauke Clausen-Schaumann, Attila Aszodi, Attila Aszodi, Paolo Alberton, Paolo Alberton   +13 more
doaj   +1 more source

Melatonin protects human nucleus pulposus cells from pyroptosis by regulating Nrf2 via melatonin membrane receptors

Bone & Joint Research, 2023
Aims: This study was performed to explore the effect of melatonin on pyroptosis in nucleus pulposus cells (NPCs) and the underlying mechanism of that effect.
Zhibiao Bai, Zeyu Shou, Kai Hu, Jiahuan Yu, Hongming Meng, Chun Chen   +5 more
doaj   +1 more source

Aggrecan: a new biomarker for acute type A aortic dissection

Scientific Reports, 2021
Acute type A aortic dissection (ATAAD) constitutes a life-threatening aortic pathology with significant morbidity and mortality. Without surgical intervention the usual mortality rate averages between 1 and 2% per hour.
K. C. König, H. Lahm, M. Dreßen, S. Doppler, S. Eichhorn, N. Beck, Kathrin Krähschütz, S. Doll, S. Holdenrieder, A. Kastrati, R. Lange, M. Krane   +11 more
semanticscholar   +1 more source

Matrix-Bound Growth Factors are Released upon Cartilage Compression by an Aggrecan-Dependent Sodium Flux that is Lost in Osteoarthritis

bioRxiv, 2021
Articular cartilage is a dense extracellular matrix-rich tissue that degrades following chronic mechanical stress, resulting in osteoarthritis (OA). The tissue has low intrinsic repair especially in aged and osteoarthritic joints.
S. J. Keppie, J. Mansfield, Xiaodi Tang, C. Philp, H. Graham, P. Önnerfjord, A. Wall, C. McLean, C. P. Winlove, M. Sherratt, G. Pavlovskaya, T. Vincent   +11 more
semanticscholar   +1 more source

Hypochlorous Acid and Chloramines Induce Specific Fragmentation and Cross-Linking of the G1-IGD-G2 Domains of Recombinant Human Aggrecan, and Inhibit ADAMTS1 Activity

Antioxidants, 2023
Atherosclerosis is a chronic inflammatory disease and a leading cause of mortality. It is characterized by arterial wall plaques that contain high levels of cholesterol and other lipids and activated leukocytes covered by a fibrous cap of extracellular ...
Yihe Wang, Astrid Hammer, Gerald Hoefler, Ernst Malle, Clare L. Hawkins, Christine Y. Chuang, Michael J. Davies   +6 more
doaj   +1 more source

Extracellular matrix fragmentation in young, healthy cartilaginous tissues [PDF]

European Cells & Materials, 2018
Although the composition and structure of cartilaginous tissues is complex, collagen II fibrils and aggrecan are the most abundant assemblies in both articular cartilage (AC) and the nucleus pulposus (NP) of the intervertebral disc (IVD).
RJ Craddock, NW Hodson, M Ozols, T Shearer, JA Hoyland, MJ Sherratt   +5 more
doaj   +1 more source

Suramin attenuates intervertebral disc degeneration by inhibiting NF-κB signalling pathway

Bone & Joint Research, 2021
Aims: Interleukin (IL)-1β is one of the major pathogenic regulators during the pathological development of intervertebral disc degeneration (IDD). However, effective treatment options for IDD are limited.
Zi-Miao Liu, Cheng-Chang Lu, Po-Chih Shen, Shih-Hsiang Chou, Chia-Lung Shih, Jian-Chih Chen, Yin Chun Tien   +6 more
doaj   +1 more source

Variable expressivity in a family with an aggrecanopathy

Molecular Genetics & Genomic Medicine, 2022
Background Osteochondritis dissecans is a condition wherein there is a subchondral bone lesion that causes pain, inflammation, and cartilage damage. Dominant Familial Osteochondritis Dissecans is a rare and severe form of osteochondritis dissecans (OCD).
Antoine Denis, Sami Chergui, Shuaa Basalom, Philippe M. Campeau, Chantal Janelle, Thierry Pauyo   +5 more
doaj   +1 more source

Transforming growth factor-β1 induces type II collagen and aggrecan expression via activation of extracellular signal-regulated kinase 1/2 and Smad2/3 signaling pathways

Molecular Medicine Reports, 2015
Yanhui Zhu, Hairong Tao, Jin Chen, Yonzhang Liu, Xiongwei Lu, Xiao Hu, Xiang Wang   +6 more
openalex   +3 more sources

CELLULAR AND MOLECULAR ACTIVITY OF A STANDARDIZED SMALL SEA FISH EXTRACT IN AN EXPERIMENTAL MODEL OF PRIMARY HUMAN CARTILAGE CELLS [PDF]

Romanian Journal of Rheumatology, 2018
The inflammatory, degenerative and rheumatic diseases are triggered and evolving at osteoarticular level due to the disruption of functionality of constitutive cells and extracellular microenvironment correlated with systemic responses as synthesis of ...
Emilia Buse, Brandusa Dumitriu, Laura Olariu, Diana Ene, Mihai Bojinca, Toma Papacocea   +5 more
doaj   +1 more source