Results 31 to 40 of about 29,689 (270)

Contributions of Chondroitin Sulfate, Keratan Sulfate and N-linked Oligosaccharides to Inhibition of Neurite Outgrowth by Aggrecan

Biology, 2020
The role of proteoglycans in the central nervous system (CNS) is a rapidly evolving field and has major implications in the field of CNS injury. Chondroitin sulfate proteoglycans (CSPGs) increase in abundance following damage to the spinal cord and ...
Thomas M. Hering, Justin A. Beller, Christopher M. Calulot, Diane M. Snow   +3 more
doaj   +1 more source

Dihydrocaffeic acid improves IL-1β-induced inflammation and cartilage degradation via inhibiting NF-κB and MAPK signalling pathways

Bone & Joint Research, 2023
Aims: Osteoarthritis (OA) is a prevalent joint disorder with inflammatory response and cartilage deterioration as its main features. Dihydrocaffeic acid (DHCA), a bioactive component extracted from natural plant (gynura bicolor), has demonstrated anti ...
Rui Lu, Ying-Guang Wang, Yunkun Qu, Shan-Xi Wang, Cheng Peng, Hongbo You, Wentao Zhu, Anmin Chen   +7 more
doaj   +1 more source

Expression of aggrecan components in perineuronal nets in the mouse cerebral cortex

IBRO Reports, 2018
Specific regions of the cerebral cortex are highly plastic in an organism’s lifetime. It is thought that perineuronal nets (PNNs) regulate plasticity, but labeling for Wisteria floribunda agglutinin (WFA), which is widely used to detect PNNs, is observed
Hiroshi Ueno, Kazuki Fujii, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Shozo Aoki, Motoi Okamoto, Takeshi Ishihara, Keizo Takao   +9 more
doaj   +1 more source

Addition of High Molecular Weight Hyaluronic Acid to Fibroblast-Like Stromal Cells Modulates Endogenous Hyaluronic Acid Metabolism and Enhances Proteolytic Processing and Secretion of Versican

Cells, 2020
We have examined the effect of exogenous linear chain high molecular weight hyaluronic acid (HMW HA) on endogenously synthesized hyaluronic acid (HA) and associated binding proteins in primary cultures of fibroblast-like stromal cells that were obtained ...
Jiapeng Xue, Jinnan Chen, Quan Shen, Deva Chan, Jun Li, Adam P. Tanguay, Tannin A. Schmidt, Faizan Niazi, Anna Plaas   +8 more
doaj   +1 more source

A nuclear magnetic resonance study of water in aggrecan solutions [PDF]

Royal Society Open Science, 2016
Aggrecan, a highly charged macromolecule found in articular cartilage, was investigated in aqueous salt solutions with proton nuclear magnetic resonance. The longitudinal and transverse relaxation rates were determined at two different field strengths, 9.
Richard J. Foster, Robin A. Damion, Thomas G. Baboolal, Stephen W. Smye, Michael E. Ries   +4 more
doaj   +1 more source

Coculture of bovine cartilage with synovium and fibrous joint capsule increases aggrecanase and matrix metalloproteinase activity

Arthritis Research & Therapy, 2017
Background A hallmark of osteoarthritis is increased proteolytic cleavage of aggrecan. Cross talk between cartilage and the synovium + joint capsule (SJC) can drive cartilage degradation by activating proteases in both tissues.
Per Swärd, Yang Wang, Maria Hansson, L. Stefan Lohmander, Alan J. Grodzinsky, André Struglics   +5 more
doaj   +1 more source

Cartilage Aggrecan Can Undergo Self-Adhesion [PDF]

Biophysical Journal, 2008
Here it is reported that aggrecan, the highly negatively charged macromolecule in the cartilage extracellular matrix, undergoes Ca(2+)-mediated self-adhesion after static compression even in the presence of strong electrostatic repulsion in physiological-like solution conditions.
Han, Lin, Dean, Delphine, Daher, Laura A., Grodzinsky, Alan J., Ortiz, Christine   +4 more
openaire   +2 more sources

Massive aggrecan and versican accumulation in thoracic aortic aneurysm and dissection.

JCI Insight, 2018
Proteoglycan accumulation is a hallmark of medial degeneration in thoracic aortic aneurysm and dissection (TAAD). Here, we defined the aortic proteoglycanome using mass spectrometry, and based on the findings, investigated the large aggregating ...
Frank S. Cikach, Christopher Koch, T. Mead, J. Galatioto, B. Willard, K. Emerton, M. Eagleton, E. Blackstone, F. Ramirez, E. Roselli, S. Apte   +10 more
semanticscholar   +1 more source

Neonatal Zika virus infection causes transient perineuronal net degradation

Frontiers in Cellular Neuroscience, 2023
Perineuronal nets (PNNs) form a specialized extracellular matrix that predominantly surrounds parvalbumin (PV)-expressing GABAergic inhibitory interneurons and help regulate neuronal activity. Their formation early in the postnatal period is regulated by
Kaliroi Engel, Ha-Na Lee, Bhanu P. Tewari, Aaron P. Lewkowicz, Derek D. C. Ireland, Mohanraj Manangeeswaran, Daniela Verthelyi   +6 more
doaj   +1 more source

Identification of a heterozygous ACAN mutation in a 15-year-old boy with short stature who presented with advanced bone age: a case report and review of the literature [PDF]

Annals of Pediatric Endocrinology & Metabolism, 2020
Longitudinal bone growth is primarily mediated by the growth plate, which is a specialized cartilaginous structure. Aggrecan, encoded by ACAN, is a primary proteoglycan component of the extracellular matrix in both the growth plate and articular ...
Tae Youp Kim, Kyung Mi Jang, Chang Won Keum, Seung Hwan Oh, Woo Yeong Chung   +4 more
doaj   +1 more source