Results 1 to 10 of about 7,503 (205)

How to perform aggregometry and lumi-aggregometry in mouse platelets [PDF]

Platelets, 2018
Light transmission aggregometry and lumi-aggregometry are the gold standard platelet assays both clinically and for basic research. The availability of different strains of genetically modified mice and mouse models of human disease means that often ...
Craig E Hughes
exaly   +6 more sources

Optimized tool for evaluation of platelet function measured by impedance aggregometry

Platelets, 2021
Platelet aggregation measured by impedance aggregometry is highly dependent on platelet count. We previously developed a tool to interpret impedance aggregometry based on the strong linear correlation between platelet counts and platelet aggregation at ...
Mette Tiedemann Skipper, Anne-Mette Hvas, Ole H Larsen   +2 more
exaly   +3 more sources

96-well plate-based aggregometry

Platelets, 2018
While there are many bench and bedside tests to assess platelet reactivity, ex vivo light transmission aggregometry (LTA) remains the gold standard.
Melissa V Chan, Paul C Armstrong, Timothy D Warner   +2 more
exaly   +5 more sources

Assessment of Platelet Storage Lesions, Viability, and Function in Canine Platelet Concentrate Units Stored at 4°C for 14 Days. [PDF]

J Vet Emerg Crit Care (San Antonio)
ABSTRACT Objective To assess platelet function, storage lesion development, and bacterial contamination in canine platelet concentrate (PC) units stored at 4°C for 14 days. Design Prospective, in vitro experimental study. Setting University teaching hospital. Animals Six units of canine PC.
Farrell KS, Epstein SE, Nguyen N, Li RHL.   +3 more
europepmc   +2 more sources

CYP2C19 Polymorphism and Platelet Aggregation-Associated Risks in Atrial Fibrillation Patients Undergoing PCI. [PDF]

Clin Transl Sci
ABSTRACT CYP2C19 genetic polymorphisms impact the antiplatelet effect of clopidogrel and associate with ischemic and bleeding risk in patients undergoing percutaneous coronary intervention (PCI). This study aimed to evaluate the association of CYP2C19 and platelet reactivity (PR) with these risks, in atrial fibrillation (AF) patients undergoing PCI ...
Gjermeni D, Szabó S, Anfang V, Vetter H, Juelch C, Rademacher S, Li T, Leggewie S, Hesselbarth D, Duerschmied D, Trenk D, Westermann D, Olivier CB.   +12 more
europepmc   +2 more sources

Receptor-Dependent and -Independent Effects of Hemin on Platelet Plasma Membrane Disintegration. [PDF]

FASEB J
Microhemorrhages lead to the release of erythrocytes, which are then degraded and lysed. These hemolyses result in the liberation of free iron‐containing hemin. Hemin induces platelet activation and ferroptosis. Inhibition of GPVI/CLEC‐2 receptor‐mediated ITAM‐signaling inhibits hemin‐induced platelet activation (low hemin concentrations). Deferoxamine,
Laspa Z, Rohlfing AK, Hochuli R, Sowa PW, Castor T, Gawaz MP.   +5 more
europepmc   +2 more sources

A Sticky Situation: Variable Agreement Between Platelet Function Tests Used to Assess Anti-platelet Therapy Response

Frontiers in Cardiovascular Medicine, 2022
BackgroundPlatelet function testing to monitor antiplatelet therapy is important for reducing thromboembolic complications, yet variability across testing methods remains challenging.
Hirotomo Nakahara, Tania Sarker, Christina L. Dean, Susana L. Skukalek, Roman M. Sniecinski, C. Michael Cawley, Jeannette Guarner, Alexander Duncan, Cheryl L. Maier   +8 more
doaj   +1 more source

Why Me? To Be an Ultra-Responder to Antiplatelet Therapy: A Case Report

Frontiers in Neurology, 2021
Background: Platelet function testing is a valid tool to investigate the clinical response to antiplatelet therapy in different clinical settings; in particular, it might supply helpful information in patients with cerebrovascular disease.
Francesca Rosafio, Guido Bigliardi, Nicoletta Lelli, Laura Vandelli, Federica Naldi, Ludovico Ciolli, Ludovico Ciolli, Stefano Meletti, Stefano Meletti, Andrea Zini   +9 more
doaj   +1 more source

Validation of Plateletworks ADP for the ProCyte Dx analyzer

Journal of Veterinary Internal Medicine, 2023
Background Platelet function testing in cats allows determination of clopidogrel effect. Plateletworks assesses aggregation based on decreasing platelet counts on hematology analyzers in response to agonists.
Matthew R. Kornya, Anthony C. G. Abrams‐Ogg, Shauna L. Blois, R. Darren Wood   +3 more
doaj   +1 more source

Multiplate^® Platelet Aggregation Findings Are Dependent on Platelet Count but Can Be Corrected by Use of a Ratio

Applied Sciences, 2020
Impedance aggregometry (Multiplate®) detects the effects of platelet aggregation inhibitors and can predict thrombotic complications after coronary and cerebrovascular stent interventions.
Mohamed Soliman, Matthias Hartmann
doaj   +1 more source