Not all light transmission aggregation assays are created equal: qualitative differences between light transmission and 96-well plate aggregometry [PDF]
In this short article, submitted as part of the review on platelet function testing, we illustrate the quantitative and qualitative differences between classical light transmission aggregometry (LTA) and 96-well plate aggregometry. We show that responses
Melissa V. Chan +3 more
doaj +2 more sources
Objectives Use of potent antiplatelet drugs requires evaluation of platelet function. While platelet function in elective cases is usually assessed in a central laboratory environment, there is also an urgent need for rapid perioperative point-of-care ...
Hanke AA +6 more
doaj +2 more sources
The role of whole blood impedance aggregometry and its utilisation in the diagnosis and prognosis of patients with systemic inflammatory response syndrome and sepsis in acute critical illness. [PDF]
OBJECTIVE: To assess the prognostic and diagnostic value of whole blood impedance aggregometry in patients with sepsis and SIRS and to compare with whole blood parameters (platelet count, haemoglobin, haematocrit and white cell count).
Gareth R Davies +9 more
doaj +6 more sources
Comparison of Aggregometry with Flow Cytometry for the Assessment of Agonists´-Induced Platelet Reactivity in Patients on Dual Antiplatelet Therapy. [PDF]
Data on the agreement between aggregometry and platelet activation by flow cytometry regarding the measurement of on-treatment platelet reactivity to arachidonic acid (AA) and adenosine diphosphate (ADP) are scarce.
Thomas Gremmel +2 more
doaj +2 more sources
Platelet dysfunction and inhibition of multiple electrode platelet aggregometry caused by penicillin
Beta-lactam antibiotics, e.g. penicillin, may inhibit platelet function and lead to reduced response in light transmission aggregometry and adhesion. However, influence on platelet function tests more commonly used in clinical practice, such as multiple ...
von Beckerath Nicolas +4 more
doaj +3 more sources
The in vitro evaluation of platelet aggregation is useful to diagnose platelet function disorders [1, 2]; in some laboratories, the test is also used to monitor antiplatelet treatment [3]. Traditionally, platelet aggregation is measured by light transmission aggregometry (LTA), which measures the changes in transmission of a beam of light through a ...
E.A. Femia +3 more
openaire +4 more sources
Evaluation of an automated light transmission aggregometry [PDF]
Light transmission aggregometry (LTA) is the “gold standard” for platelet function assessment, but it is time-consuming and labor intensive. Recently, an automated platelet aggregation method has been developed on a routine coagulation analyzer (Sysmex ...
Li-qin Ling +7 more
doaj +3 more sources
Light transmission aggregometry (LTA) is still considered as the “gold standard” for platelet function assessment but, as acompletely manual technology, it is labour intensive.
V.-E. Bret +7 more
doaj +2 more sources
Extracorporeal membrane oxygenation (ECMO) is an established therapy for patients with cardiac failure, pulmonary failure or cardiopulmonary failure. To suppress the activation of the coagulation cascade, anticoagulation is necessary.
Poonam Malhotra Kapoor +2 more
doaj +2 more sources
Aggregometry in the settings of thrombocytopenia, thrombocytosis and antiplatelet therapy
A variety of laboratory tests have been developed, which can diagnose a number of both congenital and acquired disorders of platelet function. Many tests of platelet function measure the ability of platelets to adhere to each other, forming platelet aggregates, which represent the major constituents of hemostatic plugs and of arterial thrombi.
GianMarco Podda +3 more
openaire +4 more sources

