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Platelet function testing: aggregometry and lumiaggregometry.
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Comparison of multiple electrode aggregometry with lumi‐aggregometry for the diagnosis of patients with mild bleeding disorders [PDF]
Essentials There is a clinical need for new technologies to measure platelet function in whole blood. Mild bleeding disorders were evaluated using multiple electrode aggregometry (MEA). MEA is insensitive at detecting patients with mild platelet function and secretion defects.
Neil V Morgan +2 more
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The level of platelet aggregation, measured with light transmission aggregometry (LTA) in platelet rich plasma (PRP), has been shown to predict outcomes after percutaneous coronary intervention (PCI).
Siegmund Braun +2 more
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Can platelet aggregometry be standardized?
Platelet aggregometry is an important technique which is frequently used by hemostaseologists and researchers. Gustav Born introduced the principle more than 40 years ago. Many different ways to perform aggregometry have been published. The results of aggregometry may become more comparable if some rules would be generally accepted.
H K Breddin
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In vitroassessment of platelet concentrates with multiple electrode aggregometry
Storage impairs platelet function. It was hypothesized that multiple electrode aggregometry in vitro could be used to follow aggregability in platelet concentrates over time and that the results predict the efficacy of platelet transfusion in an ex vivo ...
Camilla Hesse +2 more
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Advances in Platelet Function Testing—Light Transmission Aggregometry and Beyond
Platelet function testing is essential for the diagnosis of hemostasis disorders. While there are many methods used to test platelet function for research purposes, standardization is often lacking, limiting their use in clinical practice.
Jessica Le Blanc +2 more
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COMPUTERIZED PLATELET AGGREGOMETRY
Thrombosis and Haemostasis, 1987One of the commonly used in vitro tests for assessing platelet function is a photodensitometric assay first established by Born. However the collection and analysis of aggregation data are tedious and time consuming. The single- and dual-channel aggregometers have limited utility for the analysis of large numbers of plasma samples in clinical ...
T Szabados +4 more
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Whole Blood Platelet Aggregometry
2017Light transmittance aggregometry is the historical reference method for platelet function testing and continues to be used extensively. Whole blood impedance lumiaggregometry represents an updated methodology that provides for simplified specimen management, an assay milieu that replicates in vivo platelet activation conditions, improved ...
George A, Fritsma, David L, McGlasson
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International Journal of Laboratory Hematology, 2018
AbstractIntroductionThe “gold standard” diagnostic test for assessing in vitro platelet function, light transmission aggregometry (LTA), has limitations to application because of sample requirements. Whole blood or multiple electrode aggregometry (MEA) using the Multiplate® analyzer (Roche Diagnostics) requires smaller blood volumes and less sample ...
Ping Sun +3 more
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AbstractIntroductionThe “gold standard” diagnostic test for assessing in vitro platelet function, light transmission aggregometry (LTA), has limitations to application because of sample requirements. Whole blood or multiple electrode aggregometry (MEA) using the Multiplate® analyzer (Roche Diagnostics) requires smaller blood volumes and less sample ...
Ping Sun +3 more
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Platelet Aggregometry and Anti-Platelet Isoantibodies
Haemostasis, 2009102 sera from polytransfused patients have been screened in platelet aggregometry. Anti-human platelet isoantibodies, tested against ‘responsive’ human platelets in PRP, give in the aggregometer a decrease in optical density recorded as a sigmoidal curve.
E, Pogliani +5 more
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