The intersection of TREX1, cGAS, STING and the DNA damage theory of aging [PDF]
Frontiers in AgingGenetic syndromes of immune dysregulation have opened a door toward understanding mechanisms linking inflammation, premature aging, and normal aging.
Kate M. Jones +8 more
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Regional brain aging: premature aging of the domain general system predicts aphasia severity [PDF]
Communications BiologyPremature brain aging is associated with poorer cognitive reserve and lower resilience to injury. When there are focal brain lesions, brain regions may age at different rates within the same individual.
Natalie Busby +12 more
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Chromosome duplication causes premature aging via defects in ribosome quality control. [PDF]
PLoS BiologyDown syndrome, caused by an extra copy of Chromosome 21, causes lifelong problems. One of the most common phenotypes among people with Down syndrome is premature aging, including early tissue decline, neurodegeneration, and shortened life span.
Leah E Escalante +7 more
doaj +2 more sources
High Cardiorespiratory Fitness Protects against Molecular Impairments of Metabolism, Heart, and Brain with Higher Efficacy in Obesity-Induced Premature Aging [PDF]
Endocrinology and Metabolism, 2022 Background High cardiorespiratory fitness (CRF) protects against age-related diseases. However, the mechanisms mediating the protective effect of high intrinsic CRF against metabolic, cardiac, and brain impairments in non-obese versus obese conditions ...
Patcharapong Pantiya +11 more
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Connective tissue dysplasia as a predictor of premature skin aging
Russian Open Medical Journal, 2023 Background — One of the manifestations of connective tissue dysplasia (CTD) is premature skin aging. The latter can have different etiological factors.
Nikolai N. Potekaev +7 more
doaj +1 more source
Cosmetics, 2023 Our study aimed to develop a comprehensive approach to the management of patients with involutional skin changes, considering the predictors of premature skin aging.
Nikolai N. Potekaev +8 more
doaj +1 more source
Testicular aging, male fertility and beyond
Frontiers in Endocrinology, 2022 Normal spermatogenesis and sperm function are crucial for male fertility. The effects of healthy testicular aging and testicular premature aging on spermatogenesis, sperm function, and the spermatogenesis microenvironment cannot be ignored. Compared with
Shijue Dong +5 more
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Impact of age, antiretroviral therapy, and cancer on epigenetic aging in people living with HIV
Cancer Medicine, 2023 Background Premature aging has been identified as a global risk factor for cancer. Causes of premature aging are multifactorial, including inflammation, infection, chronic stress, and lifestyle factors.
Yulan Qing +7 more
doaj +1 more source
Accelerated aging in perinatally HIV-infected children: clinical manifestations and pathogenetic mechanisms [PDF]
, 2018 BACKGROUND: Premature aging and related diseases have been documented in HIV-infected adults. Data are now emerging also regarding accelerated aging process in HIV-infected children. METHODS: A narrative review was performed searching studies on PubMed
Bianconi, Martina +6 more
core +1 more source