Results 91 to 100 of about 101,264 (202)

Aurka-Bhlhe41 axis prevents premature aging-like microglial dysfunction and promotes remyelination

Nature Communications
Aging accelerates central nervous system remyelination failure and neurodegeneration. Microglia promote remyelination by phagocytosing myelin debris, but this function is impaired by aging-related CD22 upregulation.
Weixing Yan, Yelin Zhao, Hui Li, Li Hong, Qi Jia, Di Zhu, Dong Xiang, Li Du, Lang Hu, Ruixue Bai, Meizhen Xu, Yangyang Tang, Xinzhu Chen, Yiwei Cao, Wenyu Jia, Siyu Wang, Yuting Liu, Jinfeng Ren, Shuai Pan, Yanbiao Shi, Sijia Gao, Fuxing Dong, Jianhong Shi, Jinghua Li, Kuiyang Zheng, Jing Yang, Shuli Zhao, Hui Wang   +27 more
doaj   +1 more source

Geroprotectors as a novel therapeutic strategy for COPD, an accelerating aging disease

International Journal of COPD, 2012
Kazuhiro Ito, Thomas Colley, Nicolas MercadoAirways Disease Section, National Heart and Lung Institute, Imperial College London, London, United KingdomAbstract: Chronic obstructive pulmonary disease (COPD) progresses very slowly and the majority of ...
Ito K, Colley T, Mercado N
doaj  

Premature Aging Gene Discovered

, 1996
Werner's Syndromehttp://dx.doi.org/10.1126/science.272.5259 ...
Pennisi, Elizabeth
core  

PML Nuclear Bodies and Cellular Senescence: A Comparative Study of Healthy and Premature Aging Syndrome Donors’ Cells

Natural aging and age-related diseases involve the acceleration of replicative aging, or senescence. Multiple proteins are known to participate in these processes, including the promyelocytic leukemia (PML) protein, which serves as a core component of ...
Sergey A. Silonov, Eva A. Shmidt, Irina M. Kuznetsova, Eugene Y. Smirnov, Alexander V. Fonin, Konstantin K. Turoverov, Mirya L. Kuranova, Aleksandra V. Nozdracheva, Anna E. Romanovich, Anastasia A. Gavrilova, Nadezhda M. Pleskach   +10 more
core   +1 more source

A Novel Class of FKBP12 Ligands Rescues Premature Aging Phenotypes Associated with Myotonic Dystrophy Type 1

Background: Myotonic dystrophy type 1 (DM1) is an autosomal dominant disorder clinically characterized by progressive muscular weakness and multisystem degeneration, which correlates with the size of CTG expansion and MBLN decrease.
Ariadna Bargiela, Jorge Espinosa-Espinosa, Jesús M. Aizpurua, Adolfo López de Munain, Mikel García-Puga, Laura Mosqueira-Martín, Rubén Artero, Gorka Gerenu, Ander Matheu, Maialen Sagartzazu-Aizpurua, Ainara Vallejo-Illarramendi   +10 more
core   +1 more source

Association of dietary index for gut microbiota with premature and all-cause mortality: A mediation analysis of biological age. [PDF]

J Nutr Health Aging
Huang A, Chen S, Lin B, Hou L.
europepmc   +1 more source

Do mtDNA deletions drive premature aging in mtDNA mutator mice?

P>Deletions in mitochondrial DNA (mtDNA) have long been suspected to be involved in mammalian aging, but their role remains controversial. Recent research has demonstrated that relatively higher levels of mtDNA deletions correlate with premature aging
Turnbull DM, Kraytsberg Y, Khrapko K, Simon DK   +3 more
core  

Fisetin Supplementation Attenuates Premature Vascular Aging Induced by Doxorubicin via Suppression of Cellular Senescence and Mitochondrial Oxidative Stress. [PDF]

Aging Cell
Darrah MA, Mahoney SA, Venkatasubramanian R, VanDongen NS, Ludwig KR, Seals DR, Rossman MJ, Clayton ZS.   +7 more
europepmc   +1 more source

Replicative and stress-induced premature senescence distinctively affect the endothelial anticoagulation capacity. [PDF]

PLoS One
Katayama A, Ikeda K, Kitani T, Yamazaki E, Ueno D, Ito F, Matoba S.   +6 more
europepmc   +1 more source

Editorial: Unraveling the complexities of premature aging: mechanisms and interventions. [PDF]

Front Aging
Choubey M, Srivastava S, Kumar V.
europepmc   +1 more source