Results 71 to 80 of about 101,264 (202)

Cellular aging in cardiovascular diseases [PDF]

, 2010
As we progress to a society with an increasing average age, the problems that are associated with advanced age becoming more prominent. This is particularly visible by the increase onset of aging associated diseases, such as atherosclerosis, heart ...
Oeseburg, Hisko,, Oeseburg, Hisko
core  

Premature aging disorders: A clinical and genetic compendium

, 2020
Progeroid disorders make up a heterogeneous group of very rare hereditary diseases characterized by clinical signs that often mimic physiological aging in a premature manner.
Wollnik, Bernd, Franziska Schnabel, Schnabel, Franziska, Kornak, Uwe, Uwe Kornak, Bernd Wollnik   +5 more
core   +1 more source

Comparative induced pluripotent stem cell models of young, aged, and progeroid, as a resource to study human aging trajectories

Stem Cell Research
Human aging is heterogeneous and can be explored through development, physiological aging, and premature accelerated aging. We established human induced pluripotent stem cell (iPSC) models derived from neonatal fibroblasts, peripheral blood mononuclear ...
Mikael Magnano, Amani Wehbi, Fatimat Almentina Ramos Shidi, Mathis Soubeyrand, Romain Desprat, Paul Bensadoun, Isidor Bertrand, Vincent Gatinois, Franck Pellestor, Pamela Lemos Cruz, Richard Martin, Nathalie Cantagrel, Sophie Agat, Christiane Montastier, Ollivier Milhavet, Jean-Marc Lemaitre   +15 more
doaj   +1 more source

Premature ageing and glomerulonephritis [PDF]

Nephrology Dialysis Transplantation, 2001
N, Joss, J M, Boulton-Jones, I, More
openaire   +2 more sources

Deceleration of fusion–fission cycles improves mitochondrial quality control during aging

, 2012
Mitochondrial dynamics and mitophagy play a key role in ensuring mitochondrial quality control. Impairment thereof was proposed to be causative to neurodegenerative diseases, diabetes, and cancer.
Michael Meyer-Hermann, Michael Meyer-Hermann (124166), Andreas S. Reichert (124162), Reichert Andreas S., Heinz D. Osiewacz (120841), Figge, Marc Thilo, Reichert, Andreas S, Marc Thilo Figge, Heinz D Osiewacz, Reichert, Andreas, Meyer-Hermann Michael, Meyer-Hermann, Michael (Prof. Dr.), Osiewacz Heinz D., Meyer-Hermann, Michael, Osiewacz, Heinz D., Andreas S Reichert, Figge Marc Thilo, Marc Thilo Figge (155511), Osiewacz, Heinz D   +18 more
core   +1 more source

Lack of telomerase reduces cancer incidence and increases lifespan of zebrafish tp53 M214K mutants

Scientific Reports
Telomerase activity is restricted in humans and telomere attrition occurs in several tissues accompanying natural aging. Critically short telomeres trigger DNA damage responses and activate p53 which leads to apoptosis or replicative senescence.
Naz Şerifoğlu, Bruno Lopes-Bastos, Miguel Godinho Ferreira   +2 more
doaj   +1 more source

Canagliflozin ameliorates high-salt-induced renal injury and premature aging in male Dahl salt-sensitive rats, with associated changes in SIRT6/HIF-1α signaling

Renal Failure
Sodium–glucose cotransporter 2 inhibitors (SGLT2is) exhibit renoprotective effects in diabetic and nondiabetic patients; however, the underlying mechanism remains unclear.
Qiuyan Wang, Yi Liang, Qingjuan Zuo, Lili He, Tingting Zhang, Zhongli Wang, Jianlong Zhai, Boce Cao, Sai Ma, Guorui Zhang, Fan Lu, Yifang Guo   +11 more
doaj   +1 more source

Molecular Mechanisms Underlying Accelerated Aging by Defects in the FGF23-Klotho System

International Journal of Nephrology, 2018
The basic research of aging has been primarily focused on elucidating mechanisms of aging and longevity that are evolutionarily conserved from yeasts to primates.
Makoto Kuro-o
doaj   +1 more source

Premature Aging and Premature Age-Related Comorbidities in HIV-Infected Patients: Facts and Hypotheses [PDF]

Clinical Infectious Diseases, 2011
In the present issue of Clinical Infectious Diseases, Guaraldi et al [ 5 ] analyze the important cohort of patients followed up at the Metabolic Clinic of Modena (Italy) who underwent a complete set of clinical, biological, and imaging investigations, allowing investigation of comorbidities.
openaire   +2 more sources

IgG1 glycosylation highlights premature aging in Down syndrome [PDF]

Down syndrome (DS) is characterized by lowered immune competence and premature aging. We previously showed decreased antibody response following SARS-CoV-2 vaccination in adults with DS.
Hartog, G. den, Bont, L.J., Nouta, Jan, Binnendijk, Rob S, Wang, Wenjun, Wildenbeest, J.G., Visser, Remco, Bont, Louis J, Smits, Gaby, Linty, F., Wuhrer, M., Linty, Federica, Binnendijk, R.S., Van Coillie, Julie, Nouta, J., Coillie, J. van, Smits, G., Streng, B.M.M., Wang, W.J., Visser, R., Streng, Bianca MM, Vidarsson, G., Wuhrer, Manfred, den Hartog, Gerco, Wildenbeest, Joanne G, Vidarsson, Gestur   +25 more
core   +2 more sources