Results 81 to 90 of about 101,264 (202)

The tight bond between Fanconi anemia and aging

Frontiers in Aging
Fanconi anemia (FA) is a rare genetic disorder characterized by genomic instability, bone marrow failure, physical abnormalities, and increased cancer susceptibility. Growing evidence suggests that.
Marco Antonio Mejía-Barrera, Marco Antonio Mejía-Barrera, Enya Enara Martínez-Torres, Enya Enara Martínez-Torres, Ulises Juárez-Figueroa, Leda Torres, Moisés O. Fiesco-Roa, Benilde García-de-Teresa, Juan Carlos Gomez-Verjan, Jorge Meléndez-Zajgla, Alfredo Rodríguez, Alfredo Rodríguez, Silvia Sánchez, Bertha Molina, Sara Frias, Sara Frias   +15 more
doaj   +1 more source

Risk of retinopathy of prematurity in small for gestational age premature infants

Indian Pediatrics, 2014
To evaluate the incidence, risk factors and severity of retinopathy of prematurity in neonatal intensive care unit and to evaluate its relationship with gestational age.Cohort study of neonates with gestational age ≤ 32 weeks or birthweight ≤ 1500 g.Of the 495 neonates screened, 43 (8.7%) infants were small for gestational age; the frequency of severe ...
Bas, AHMET YAĞMUR, Demirel, NİHAL, Aydemir, O, Özcan, B, Kavurt, S   +4 more
openaire   +3 more sources

Genomic Instability in Laminopathy-based Premature Aging

, 2005
Premature aging syndromes often result from mutations in nuclear proteins involved in the maintenance of genomic integrity. LAMIN A is a major component of the nuclear lamina and nuclear skeleton.
Zhou, Z
core   +2 more sources

Skin Disease in Laminopathy-Associated Premature Aging

, 2015
The nuclear lamina, a protein network located under the nuclear membrane, has during the past decade found increasing interest due to its significant involvement in a range of genetic diseases, including the segmental premature aging syndromes Hutchinson–
Eriksson, Maria, Sola Carvajal, Agustín, Eriksson, M,, McKenna, T, McKenna, Tomás, Sola, Carvajal A,   +5 more
core   +1 more source

Targeting the phospholipase A2 receptor ameliorates premature aging phenotypes

, 2018
International audienceHutchinson–Gilford progeria syndrome (HGPS) is a lethal premature aging that recapitulates many normal aging characteristics. This disorder is caused by mutation in the LMNA gene leading to the production of progerin which induces ...
Le Calvé, Benjamin, Ziegler, Dorian, Marine Warnier, Nadine Martin, Benjamin Le Calvé, David Vindrieux, Dorian V. Ziegler, Martin, Nadine, Djebali, Sophia, Martin O. Bergo, Bernard, David, Audrey Griveau, Griveau, Audrey, Vindrieux, David, Warnier, Marine, Clotilde Wiel, Sophia Djebali, Wiel, Clotilde, Bergo, Martin, Marvel, Jacqueline, David Bernard, Jacqueline Marvel   +21 more
core   +2 more sources

RETRACTED ARTICLE: Anti-aging Effect of Transplanted Amniotic Membrane Mesenchymal Stem Cells in a Premature Aging Model of Bmi-1 Deficiency

Scientific Reports, 2015
To determine whether transplanted amniotic membrane mesenchymal stem cells (AMSCs) ameliorated the premature senescent phenotype of Bmi-1-deficient mice, postnatal 2-day-old Bmi-1−/− mice were injected intraperitoneally with the second-passage AMSCs from
Chunfeng Xie, Jianliang Jin, Xianhui Lv, Jianguo Tao, Rong Wang, Dengshun Miao   +5 more
doaj   +1 more source

Transgenic mice overexpressing glia maturation factor-β, an oxidative stress inducible gene, show premature aging due to Zmpste24 down-regulation

, 2015
Glia Maturation Factor-β (GMF), a brain specific protein, is induced by proteinuria in renal tubules. Ectopic GMF overexpression causes apoptosis in vitro via cellular vulnerability to oxidative stress.
Hanai, Jun-ichi, Takenaka, Masaru, Asai, Kanae, Imai, Rika   +3 more
core  

Genetic basis of cardiovascular aging is at the core of human longevity

, 2022
Aging is an archetypical complex process influenced by genetic and environmental factors. Genetic variants impart a gradient of effect sizes, albeit the effect sizes seem to be skewed toward those with small effect sizes.
Marian, Ali J.
core  

Missing checkpoints in premature aging

Nature Aging, 2023
Huijing Xue, Kan Cao
openaire   +2 more sources

Premature aging in chronic kidney disease and chronic obstructive pulmonary disease

, 2015
Purpose of review: There is increasing clinical and pathophysiological evidence that a premature aging process is involved in the pathogenesis of systemic complications of many chronic organ diseases, which result in analogous phenotypes, including ...
Shiels, PG, Stenvinkel, Peter, Kooman, Jeroen P., Shiels, P.G., Stenvinkel, P,, Stenvinkel, P., Kooman, JP, Shiels, Paul G., Kooman, J.P.   +8 more
core   +1 more source