Chromosome duplication causes premature aging via defects in ribosome quality control.
PLoS BiologyDown syndrome, caused by an extra copy of Chromosome 21, causes lifelong problems. One of the most common phenotypes among people with Down syndrome is premature aging, including early tissue decline, neurodegeneration, and shortened life span.
Leah E Escalante +7 more
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Telomerase Protects Werner Syndrome Lineage-Specific Stem Cells from Premature Aging
Stem Cell Reports, 2014 Werner syndrome (WS) patients exhibit premature aging predominantly in mesenchyme-derived tissues, but not in neural lineages, a consequence of telomere dysfunction and accelerated senescence.
Hoi-Hung Cheung +5 more
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Premature brain aging in humans exposed to maternal nutrient restriction during early gestation
, 2018 BACKGROUND: Prenatal exposure to undernutrition is widespread in both developing and industrialized countries, causing irreversible damage to the developing brain, resulting in altered brain structure and decreased cognitive function during adulthood ...
Roseboom, Tessa J +11 more
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A multiparametric anti-aging CRISPR screen uncovers a role for BAF in protein synthesis regulation
Nature CommunicationsProgeria syndromes are very rare, incurable premature aging conditions recapitulating most aging features. Here, we report a whole genome, multiparametric CRISPR screen, identifying 43 genes that can rescue multiple cellular phenotypes associated with ...
Sophia Y. Breusegem +11 more
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Premature aging and metabolic diseases: the impact of telomere attrition
Frontiers in AgingDriven by genetic and environmental factors, aging is a physiological process responsible for age-related degenerative changes in the body, cognitive decline, and impaired overall wellbeing.
Sandhya Jinesh +2 more
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The Centrality of Variability: How society shapes patterns of aging [PDF]
Increasing variability is a hallmark of aging populations. Although demographic trends are often described in terms of average experiences, in this paper we argue that variability in the health experiences of older men and women is key to understanding ...
Lisa F. Berkman, Maria Glymour
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DNA repair in premature aging disorders and neurodegeneration
, 2010 The accumulation of DNA damage has been widely implicated in premature aging and neurodegeneration. Progeroid syndromes with defects in the cellular response to DNA damage suggest that progressive genome instability represents an important aspect of the ...
COPPEDE', FABIO, MIGLIORE, LUCIA
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Farnesyltransferase inhibitor treatment restores chromosome territory positions and active chromosome dynamics in Hutchinson-Gilford progeria syndrome cells [PDF]
, 2011 Copyright @ 2011 Mehta et al.; licensee BioMed Central Ltd. This article has been made available through the Brunel Open Access Publishing Fund. This is an open access article distributed under the terms of the Creative Commons Attribution License ...
Christopher H Eskiw +9 more
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Trophoblast Extracellular Vesicles as Modulators of Keratinocyte Stress Response and Senescence
LifeKeratinocyte stress, caused by various intrinsic and extrinsic factors, contributes to the overall aging process. D-galactose-induced metabolic/oxidative stress is a commonly used in vitro model for studying premature aging. Due to their rich composition
Mirjana Nacka-Aleksić +6 more
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, 2017 : Recent research has proposed that GIT2 (G protein-coupled receptor kinase interacting protein 2) acts as an integrator of the aging process through regulation of 'neurometabolic' integrity. One of the commonly accepted hallmarks of the aging process is
van Gastel, Jaana +41 more
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