Results 51 to 60 of about 101,264 (202)
Lamin A/C, laminopathies and premature ageing.
Histology and histopathology, 2008 Lamin A/C belongs to type V intermediate filaments and constitutes the nuclear lamina and nuclear matrix, where a variety of nuclear activities occur. Lamin A/C protein is firstly synthesized as a precursor and is further proteolytically processed by the zinc metallo-proteinase Ste24 (Zmpste24).
Zhou, Z, Liu, B
openaire +4 more sources
Molecular signatures of premature aging in Major Depression and Substance Use Disorders
Scientific DataMajor depressive disorder (MDD) and substance-use disorders (SUDs) often lead to premature aging, increasing vulnerability to cognitive decline and other forms of dementia. This study utilized advanced systems bioinformatics to identify aging “signatures”
Anna Onisiforou +2 more
doaj +1 more source
Are There Common Mechanisms Between the Hutchinson–Gilford Progeria Syndrome and Natural Aging?
Frontiers in Genetics, 2019 The Hutchinson–Gilford progeria syndrome (HGPS) is a premature aging disease caused by mutations of the LMNA gene leading to increased production of a partially processed form of the nuclear fibrillar protein lamin A – progerin.
Vasily V. Ashapkin +3 more
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Loss of αklotho causes reduced motor ability and short lifespan in zebrafish
Scientific Reports, 2021 The klotho gene encodes a transmembrane protein αKlotho that interacts with a fibroblast growth factor (FGF) receptor in renal tubular epithelial cells and functions as a co-receptor for FGF23, which is an osteocytes-derived hormone.
Yurie Ogura +4 more
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Clinical and laboratory criteria for occult form of premature ovarian failure [PDF]
Гинекология, 2018 Purpose of the study. To develop clinical and laboratory criteria characteristic of the occult (hidden) form of premature ovarian failure. Material and methods.
L A Marchenko, R I Mashaeva
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Biological Aging and Immune Senescence in Children with Perinatally Acquired HIV
Journal of Immunology Research, 2020 Chronic HIV-infected children suffer from premature aging and aging-related diseases. Viral replication induces an ongoing inflammation process, with the release of pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns ...
Annalisa Dalzini +5 more
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground Pathogenic variants in PKP2 are the most common cause of familial arrhythmogenic right ventricular cardiomyopathy. This study tests whether plakophilin‐2 (PKP2) deficiency only in cardiomyocytes is sufficient to provoke premature aging and ...
Giorgia Bertoli +16 more
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Effect of training on improving swimming biological age and capabilities of people aged 30-35 years
Pedagogics, Psychology, Medical-Biological Problems of Physical Training and Sports, 2014 Purpose: to verify the anti-aging effect of improving navigation on involution processes of the human body 30-35. Material: participation in the experiment took 43 men and women aged 30-35 years. Biological age is measured by the method of V.P. Voytenko.
N.V. Fedinyak
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Experimental and Molecular Medicine, 2018 Aging: Clues in nuclear proteins Abnormal versions of proteins that support the structure and function of the membrane of the cell nucleus are implicated in premature aging disorders, and also in normal aging.
Jin Young Lee +9 more
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A Case Report of Hutchinson-Gilford Progeria Syndrome
The Journal of Qazvin University of Medical Sciences, 2019 Hutchinson-Gilford Progeria Syndrome (HGPS), a rare genetic condition occurs one in every 8 million live births. HGPS is characterized by premature aging in various organs.
Siamak Yaghoubi +4 more
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