Results 111 to 120 of about 211,860 (282)
Advanced Healthcare Materials, EarlyView.This review highlights recent progress in nanocarriers targeting pattern recognition receptors (PRRs), including Toll‐like and NOD‐like receptors, for enhancing the treatment of bacterial sepsis and related complications. These nanomedicines deliver antibiotics and anti‐inflammatory agents while modulating immune responses.
Eman A. Ismail +3 more
wiley +1 more source
Aging-induced stem cell mutations as drivers for disease and cancer [PDF]
, 2015 Aging is characterized by a decrease in genome integrity, impaired organ maintenance, and an increased risk of cancer, which coincide with clonal dominance of expanded mutant stem and progenitor cell populations in aging tissues, such as the intestinal ...
Adams, Peter D. +2 more
core +1 more source
Premature Aging and Premature Age-Related Comorbidities in HIV-Infected Patients: Facts and Hypotheses [PDF]
Clinical Infectious Diseases, 2011 In the present issue of Clinical Infectious Diseases, Guaraldi et al [ 5 ] analyze the important cohort of patients followed up at the Metabolic Clinic of Modena (Italy) who underwent a complete set of clinical, biological, and imaging investigations, allowing investigation of comorbidities.
openaire +3 more sources
Immunosuppressive Cytokine‐Tethered Hydrogel for Treating Rheumatoid Arthritis
Advanced Healthcare Materials, EarlyView.An injectable hydrogel is developed by chemically tethering IL‐4, an immunosuppressive cytokine, to a hyaluronic acid‐based backbone. The hydrogel reduces joint friction and exerts immunomodulatory effects. In a rheumatoid arthritis (RA) mouse model, it reduced inflammation, preserved cartilage, and promoted anti‐inflammatory immune responses.
Woojin Back +3 more
wiley +1 more source
Regional brain aging: premature aging of the domain general system predicts aphasia severity
Communications BiologyPremature brain aging is associated with poorer cognitive reserve and lower resilience to injury. When there are focal brain lesions, brain regions may age at different rates within the same individual.
Natalie Busby +12 more
doaj +1 more source
Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration. [PDF]
, 2014 The regenerative capacity of skeletal muscle declines with age. Previous studies suggest that this process can be reversed by exposure to young circulation; however, systemic age-specific factors responsible for this phenomenon are largely unknown.
Chen, Robert Y +8 more
core +1 more source
Advanced Materials, EarlyView.Advancing gas‐phase electrolysis toward industrial‐scale applications requires not only the development of advanced electrocatalysts but also the design of the electrodes to optimize gas‐electrode‐electrolyte interfaces and facilitate efficient mass transport, thereby reinforcing gas win the electrons to promote reaction kinetics and suppress side ...
Guoliang Chen +8 more
wiley +1 more source
Oxidative stress and epigenetic regulation in ageing and age-related diseases [PDF]
, 2013 Recent statistics indicate that the human population is ageing rapidly. Healthy, but also diseased, elderly people are increasing. This trend is particularly evident in Western countries, where healthier living conditions and better cures are available ...
Cencioni, Chiara +6 more
core +2 more sources
Electrospinning and Nanofiber Technology: Fundamentals, Innovations, and Applications
Advanced Materials, EarlyView.This review explores electrospinning fundamentals, methods for synthesizing polymer, metal oxide, carbon, and composite nanofibers, and advancements in fiber architectures like porous, core–shell, and aligned structures. It highlights applications in functional membranes, sensors, energy systems, and catalyst design while addressing future ...
Yujang Cho +5 more
wiley +1 more source
Advanced Materials, EarlyView.This study presents a polyanhydride‐based delivery platform for single‐injection, self‐boosting vaccines. The system enables programmable, pulsatile release of diphtheria toxoid with high antigen recovery and is guided by machine learning for tunability. In vivo results show immune responses comparable to multi‐dose regimens, highlighting its potential
Linzixuan Zhang +17 more
wiley +1 more source