Results 171 to 180 of about 99,091 (265)

PARP Inhibitors plus Anlotinib as Bridging Therapy for Armored CAR‐T Cells in Ovarian Cancer Enhances Infiltration and Antitumor Efficacy

Advanced Science, EarlyView.
This study shows that a PARP inhibitor combined with anlotinib, administered as bridging therapy, preconditions the tumor microenvironment to enhance the infiltration and antitumor activity of subsequently infused CAR‐T cells across preclinical ovarian cancer models, supporting bridging therapy as a promising strategy to address limited CAR‐T cell ...
Huayi Li, Minghua Xiang, Qiuyang Xu, Jiahao Liu, Xiaofei Jiao, Wei Mu, Xiaoying Lv, Kangjia Tao, Yu Xu, Dongchen Zhou, Wenjian Gong, Danmei Yan, Yixin Hu, Sen Xu, Bingbing Zhao, Jundong Li, Yongkang Gai, Guang Hu, Li Zhu, Qinglei Gao, Yong Fang   +20 more
wiley   +1 more source

Dermatologic manifestations in an adult with Williams syndrome. [PDF]

JAAD Case Rep
Brigenti N, Danese A, Girolomoni G, Maurelli M.   +3 more
europepmc   +1 more source

Maternal Exercise Rescues Embryonic Osteogenesis Impaired due to POLG Mutation Through a Potential Apelin‐ATF4 Axis

Advanced Science, EarlyView.
Maternal exercise (ME) increases apelin abundance across maternal and fetal tissues and is associated with improved fetal osteogenesis under POLG mutation‐induced mitochondrial dysfunction. Apelin‐APJ signaling is linked to enhanced mitochondrial function, Akt phosphorylation, and ATF4‐RUNX2 association, supporting coordinated fetal bone remodeling ...
Song Ah Chae, Ryan C. Riddle, Zhihua Jiang, Chaeyoung Shin, Min Du, Jun Seok Son   +5 more
wiley   +1 more source

Lonafarnib clinical trials demonstrate uncoupling of the muscle-bone unit in Hutchinson-Gilford Progeria Syndrome. [PDF]

J Bone Miner Res
Kreienkamp RJ, Gordon LB, Ehrbar R, Pendleton A, Schiferl DJ, Lyass A, Kleinman ME, Snyder BD, Gordon CM.   +8 more
europepmc   +1 more source

Single‐Cell Profiling Reveals a Protective WNT5A‐ATF3‐FOSB Signaling Axis in Hair Follicle Stem Cells During Androgenetic Alopecia

Advanced Science, EarlyView.
Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo, Ke Fang, Changjiang Zhao, Jiachao Xiong, Yuan Zhu, Mingyang Lu, He Yan, Zihan Li, Baojin Wu, Hua Jiang, Yufei Li   +10 more
wiley   +1 more source

Quantifying brain-age gap in people with HIV on antiretroviral therapy using plasma neurofilament light chain. [PDF]

AIDS
Park H, Hyle EP, Tassiopoulos KK, Gisslén M, Rubin LH, Mukerji SS, Parker RA.   +6 more
europepmc   +1 more source

Versatile Co‐Engineering of Immunogenic Cell Death‐Primed Dead Tumor Cell Bodies With Tumor‐Activated MnO2 for cGAS‐STING‐Potentiated Personalized Immunotherapy

Advanced Science, EarlyView.
DTBEI@CS@MnO2, fabricated via modular electrostatic co‐engineering and photothermal/photodynamic immunogenic cell death, specifically responds to the acidic and GSH‐rich tumor microenvironment. This triggers the release of DTBEI that provides tumor antigens, DNA, and DAMPs, as well as the generation of Mn2+, thereby synergistically potentiating cGAS ...
Bolun Xu, Xuan Lu, Yuquan Wang, Haihua Ji, Ying Zhang, Yiqun Wan, Hao Wan   +6 more
wiley   +1 more source

Aging-related deficits accumulation and cancer-related outcomes in testicular and prostate cancer: Cross-sectional and longitudinal findings. [PDF]

Soc Sci Med
Hoyt MA, Llave K, Carroll JE, Haydon MD.
europepmc   +1 more source

Lithium‐Ion Battery Safety Evaluation by Quantifying Lithium Plating Degree Based on Pressure Signals

Advanced Science, EarlyView.
Low N/P cells enable controllable lithium plating, allowing the lithium plating degree (DLi) to be quantified and linked to thermal safety. Pressure signals during calibration provide a non‐destructive route to diagnose DLi, while thermal response tests define safety levels and management strategies. The framework remains applicable in commercial 12 Ah
Haonan Liu, Jiangong Zhu, Wenyuan Weng, Bin Shen, Wenjun Fan, Yang Wang, Huapeng Lu, Wuliyasu He, Chunjing Lin, Xuezhe Wei, Haifeng Dai   +10 more
wiley   +1 more source

Treatment for Hyperosmolar Dehydration in Hospitalised Adults: Protocol for a Scoping Review of Current Evidence and Gaps. [PDF]

JMIR Res Protoc
Hansen CH, Mortensen LT, Brandstrup B, Beck AM, Andersen S, Danielsen MB.   +5 more
europepmc   +1 more source