Results 181 to 190 of about 1,168,781 (390)
Evidence for a Second Desensitized State of β‐Adrenergic Receptor with Low Affinity for β‐Antagonists and Normal Reactivity towards β‐Agonists in Adipocyte Membranes Previously Exposed to β‐Antagonists [PDF]
, 1979 Yves Giudicelli +2 more
openalex +1 more source
The LDH‐H3K18La‐Nur77 Axis Potentiates Immune Escape in Small Cell Lung Cancer
Advanced Science, EarlyView.Lactate from SCLC tumors induces H3K18 lactylation in naïve CD8+ T cells, upregulating Nurr77 and enhancing tonic TCR signaling. This leads to T cell hyporesponsiveness to stimulation, impairing antitumor immunity and reducing immunotherapy efficacy.
Xiaoling Shang +16 more
wiley +1 more source
Enhanced Media Optimize Bovine Myogenesis in 2D and 3D Models for Cultivated Meat Applications
Advanced Science, EarlyView.This study uses multiomics approaches to characterize bovine myogenesis in vitro, identifying media components that enhance myogenic progenitor cell differentiation in 2D and 3D models. Notably, the enhanced conditions promoted formation of unique cell populations and contractile muscle cells expressing mature myogenic markers.
Christine L. Trautmann +4 more
wiley +1 more source
Crystal structures of agonist-bound human cannabinoid receptor CB1
Nature, 2017 T. Hua +19 more
semanticscholar +1 more source
Advanced Science, EarlyView.This study reveals a novel mechanism of resistance to DNA hypomethylating agents (HMAs) in acute myeloid leukemia (AML), and identifies all‐trans retinoic acid (ATRA) and tamibarotene (TAM) as potent agents that overcome HMA resistance by reactivating the interferon anticancer immune response. The findings offer promising therapeutic strategies for HMA‐
Xueqin Chen +18 more
wiley +1 more source
Advanced Science, EarlyView.This study investigates hypoglycemia‐induced diabetic macrovascular endothelial dysfunction. It reveals that hypoglycemia triggers ZBP1‐dependent PANoptosis of endothelial cells, proinflammatory polarization of macrophages, and fibrosis of vascular smooth muscle cells (VSMCs) in diabetic mice.
Deyu Zuo +10 more
wiley +1 more source
Agonist regulation of α-adrenergic receptor numbers (reply) [PDF]
, 1979 R. Wayne Alexander, Robert I. Handin
openalex +1 more source
Activation of human brown adipose tissue by a β3-adrenergic receptor agonist.
Cell Metabolism, 2015 A. Cypess +10 more
semanticscholar +1 more source
Advanced Science, EarlyView.This study demonstrates that the transport of lactate to the mitochondria is of critical importance in determining the functions of macrophages by altering mitochondrial respiration. In macrophages, this lactate transport mechanism regulates glucose homeostasis by influencing the functions of insulin‐secreting cells in the pancreatic islets.
Lingling Chen +9 more
wiley +1 more source
Labour retarded with β‐agonist drugs [PDF]
, 1978 J. W. Downing, John Brock-Utne
openalex +1 more source