Results 181 to 190 of about 1,200,697 (382)

Amide Analogues of CD1d Agonists Modulate iNKT-Cell-Mediated Cytokine Production [PDF]

, 2012
Justyna Wojno, John‐Paul Jukes, Hemza Ghadbane, Dawn Shepherd, Gurdyal S. Besra, Vincenzo Cerundolo, Liam R. Cox   +6 more
openalex   +1 more source

Exploring Functionally Enhanced BLP‐Trained Macrophage Subpopulations in S. Aureus Infection: Underlying Mechanisms and Therapeutic Significance

Advanced Science, EarlyView.
BLP‐trained macrophages show augmented resistance to infection, but their mechanisms remain unclear. scRNA‐seq identified 13 BMDM subsets, with two novel anti‐inflammatory/antibacterial subpopulations (C5/C7) emerging post‐BLP training. BLP training activates NRF2, attenuates oxidative stress/ferroptosis, and boosts glycolysis/OXPHOS. Adoptive transfer
Yantong Wan, Yinghao Hong, Xiangjun Ji, Jing Xiang, Jinxi Liu, Lixin Liang, Meng Ren, Wenhan Chen, Tengfei Xu, Zhijie Li, Tieliu Shi, Yong Jiang, Huaping Liang, Jinghua Liu   +13 more
wiley   +1 more source

Decreased bronchodilating effect of salbutamol in relieving methacholine induced moderate to severe bronchoconstriction during high dose treatment with long acting beta2 agonists

, 2001
H. J. van der Woude
openalex   +2 more sources

Circulating levels of proglucagon‐derived peptides are differentially regulated by the glucagon‐like peptide‐1 agonist liraglutide and the centrally acting naltrexone/bupropion and can predict future weight loss and metabolic improvements: A 6‐month long interventional study [PDF]

, 2023
Konstantinos Stefanakis, Alexander Kokkinos, Georgia Argyrakopoulou, Sofia Konstantinidou, Stamatia Simati, Matina Kouvari, Ajay Kumar, Bhanu Kalra, Melina Kumar, Nikolaos Bontozoglou, Konstantina Kyriakopoulou, Christos S. Mantzoros   +11 more
openalex   +1 more source

RELA Ablation Contributes to Progression of Hepatocellular Carcinoma with TP53R249S Mutation and is a Potential Therapeutic Target

Advanced Science, EarlyView.
Genome‐wide CRISPR/Cas9 based screening identified RELA as a key tumor suppressor in TP53R249S‐mutant HCC. Its loss promotes tumorigenesis and metastasis via DVL1‐mediated Wnt/β‐catenin activation, while its agonist betulinic acid suppresses tumor progression.
Zhiping Wu, Zhe Wang, Diwei Zheng, Yongfang Zheng, Zhiwu Jiang, Jiang Lv, Yueqin Zhu, Heng Jia, Ziyuan Duan, Tingjie Yuan, Qiting Wu, Youguo Long, Shouheng Lin, Yao Yao, Georgia Carson, Jean P. Thiery, Kwan Man, Peng Li   +17 more
wiley   +1 more source

Crystal structures of agonist-bound human cannabinoid receptor CB1

Nature, 2017
T. Hua, K. Vemuri, S. Nikas, Yiran Wu, L. Qu, M. Pu, Anisha Korde, Shan Jiang, Jo-Hao Ho, G. Han, K. Ding, Xuanxuan Li, Haiguang Liu, M. Hanson, Suwen Zhao, L. Bohn, A. Makriyannis, R. Stevens, Zhi-jie Liu   +18 more
semanticscholar   +1 more source

Cinobufagin Directly Targets PDE4D to Disrupt Fibroblast–Dendritic Cell Crosstalk in Atopic Dermatitis

Advanced Science, EarlyView.
Single‐cell RNA sequencing revealed that MIF signaling drives inflammatory fibroblastmyeloid cell crosstalk in atopic dermatitis. Cinobufagin, a potent PDE4D inhibitor, suppresses MIF and reduces inflammation by restoring the cAMP/PKA/CREB pathway. Genetic knockout validates PDE4D as a key driver and promising therapeutic target for atopic dermatitis ...
Shicong Li, Dihui Xu, Chenyang Zhang, Chunxiu Xiao, Meng Yu, Jiaojiao Wang, Wenyuan Wu, Xiang Lv, Dongping Yuan, Liang Zhang, Min Hong, Jing Zhou, Yang Sun, Hongyue Ma, Yuyu Zhu   +14 more
wiley   +1 more source

A TLR9 agonist synergistically enhances protective immunity induced by an Alum-adjuvanted H7N9 inactivated whole-virion vaccine [PDF]

, 2023
Tsai-Teng Tzeng, Kit Man Chai, I‐Hua Chen, Ray-Yuan Chang, Jen-Ron Chiang, Shih‐Jen Liu   +5 more
openalex   +1 more source

agonist

, 2019
Citation: 'agonist' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.A00186 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms. Requests for commercial usage
openaire   +1 more source

Activation of human brown adipose tissue by a β3-adrenergic receptor agonist.

Cell Metabolism, 2015
A. Cypess, Lauren S Weiner, C. Roberts-Toler, Elisa Franquet Elía, Skyler Kessler, Peter Kahn, Jeffrey English, K. Chatman, S. Trauger, Alessandro Doria, G. Kolodny   +10 more
semanticscholar   +1 more source