Results 101 to 110 of about 722,561 (200)

UCP2 mediates mitochondrial dynamics to induce AgRP neuronal activity

Molecular Metabolism
Objectives: The hypothalamic agouti-related protein (AgRP)- expressing neurons regulate feeding and whole-body energy homeostasis. A growing body of evidence indicates that changes in mitochondrial dynamics, such as fission and fusion, play a crucial ...
Sungho Jin, Nal Ae Yoon, Zhong-Wu Liu, Ciro Menale, Jung Dae Kim, Nadia Diano, Sabrina Diano   +6 more
doaj   +1 more source

Opioidergic signaling contributes to food-mediated suppression of AgRP neurons

Cell Reports
Summary: Opioids are generally known to promote hedonic food consumption. Although much of the existing evidence is primarily based on studies of the mesolimbic pathway, endogenous opioids and their receptors are widely expressed in hypothalamic appetite
Nilufer Sayar-Atasoy, Yavuz Yavuz, Connor Laule, Chunyang Dong, Hyojin Kim, Jacob Rysted, Kyle Flippo, Debbie Davis, Iltan Aklan, Bayram Yilmaz, Lin Tian, Deniz Atasoy   +11 more
doaj   +1 more source

Ghrelin receptors mediate ghrelin‐induced excitation of agouti‐related protein/neuropeptide Y but not pro‐opiomelanocortin neurons

Journal of Neurochemistry, 2017
Shao-Rui Chen, Hong Chen, Jing-Jing Zhou, G. Pradhan, Yuxiang Sun, H. Pan, De-Pei Li   +6 more
semanticscholar   +1 more source

FTO promotes weight gain via altering Kif1a splicing and axonal vesicle trafficking in AgRP neurons

The EMBO Journal
N6-methyladenosine (m6A) is an abundant chemical RNA modification involved in the regulation of many biological processes. The m6A demethylase FTO (fat mass and obesity-associated protein) is known to affect body weight, but its systemic context and ...
Daisuke Kohno, Reika Kawabata-Iwakawa, Sotaro Ichinose, Shigetomo Suyama, Kazuto Ohashi, Winda Ariyani, Tetsushi Sadakata, Hiromi Yokota-Hashimoto, Ryosuke Kobayashi, Takuro Horii, Vina Yanti Susanti, Ayumu Konno, Haruka Tsuneoka, Chiharu Yoshikawa, Sho Matsui, Akihiro Harada, Toshihiko Yada, Izuho Hatada, Hirokazu Hirai, Masahiko Nishiyama, Tsutomu Sasaki, Tadahiro Kitamura   +21 more
doaj   +1 more source

Noradrenergic control of bone marrow and thymus by AgRP neurons is impaired in experimental multiple sclerosis

Cell Reports
Summary: Maturation of hematopoietic stem and progenitor cells (HSPCs) in the bone marrow (BM) and of T lymphocytes in the thymus occurs within stromal regions innervated by noradrenergic fibers of the sympathetic nervous system (SNS).
Tiziana Vigo, Maria C. Mariani, Caterina Bason, Giovanni Ferrara, Eleonora Cornacchia, Simona Francia, Alberto Potenzieri, Erika Ricci, Giorgio Grasselli, Gabriele Zoppoli, Gabriella Cirmena, Lorenzo Ferrando, Claudio Procaccini, Claudia Russo, Tiziana Altosole, Elena Cerutti, Giovanna Capodivento, Marta Bottero, Luca Liberale, Marco Scotto, Alice Laroni, Matilde Inglese, Sebastian Sulis Sato, Jonatas Catarino, Diego Centonze, Giuseppe Matarese, Fabio Benfenati, Tamas L. Horvath, Nicole Kerlero de Rosbo, Antonio Uccelli   +29 more
doaj   +1 more source

Interactions between SNP Alleles at Multiple Loci Contribute to Skin Color Differences between Caucasoid and Mongoloid Subjects

International Journal of Biological Sciences, 2008
This study aimed to identify single nucleotide polymorphism (SNP) alleles at multiple loci associated with racial differences in skin color using SNP genotyping.
Sumiko Anno, Takashi Abe, Takushi Yamamoto
doaj  

Incorporation of Agouti-Related Protein (AgRP) Human Single Nucleotide Polymorphisms (SNPs) in the AgRP-Derived Macrocyclic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-dPro] Decreases Melanocortin-4 Receptor Antagonist Potency and Results in the Discovery of Melanocortin-5 Receptor Antagonists. [PDF]

J Med Chem, 2020
Koerperich ZM, Ericson MD, Freeman KT, Speth RC, Pogozheva ID, Mosberg HI, Haskell-Luevano C.   +6 more
europepmc   +1 more source

Fish protein hydrolysate exhibits anti-obesity activity and reduces hypothalamic neuropeptide Y and agouti-related protein mRNA expressions in rats.

Biomedical research, 2017
T. Mizushige, Masaki Komiya, Moe Onda, Kenji Uchida, Kohsuke Hayamizu, Y. Kabuyama   +5 more
semanticscholar   +1 more source

Central and peripheral leptin and agouti‐related protein during and after pregnancy in relation to weight change

Clinical Endocrinology, 2018
Ulrika Andersson-Hall, Pernilla Svedin, U. Andreasson, M. Gren, Ameli Ingemansson, H. Zetterberg, K. Blennow, Aurimantas Pelanis, C. Mallard, A. Holmäng   +9 more
semanticscholar   +1 more source

Photostimulation increases food intake, agouti-related protein (AGRP) and type II iodothyronine deiodinase (DIO2) gene expression in the medio-basal hypothalamus of Gambel's White-crowned Sparrow. [PDF]

J Neuroendocrinol
Boswell T, Boswell T, Olson SK, Bentley GE, Perfito N, Ramenofsky M.   +5 more
europepmc   +1 more source