Results 81 to 90 of about 12,122 (173)

Determinants of body weight regulation in humans

Archives of Endocrinology and Metabolism, 2016
Body weight is regulated by the ability of hypothalamic neurons to orchestrate behavioral, endocrine and autonomic responses via afferent and efferent pathways to the brainstem and the periphery.
Milene Moehlecke, Luis Henrique Canani, Lucas Oliveira Junqueira e Silva, Manoel Roberto Maciel Trindade, Rogerio Friedman, Cristiane Bauermann Leitão   +5 more
doaj   +1 more source

Changes in body composition in genetic C9orf72 carriers: The role of the hypothalamus and thalamus

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract BACKGROUND Patients with sporadic frontotemporal dementia (FTD) display changes in metabolism and body composition. No studies have examined body composition changes in pre‐symptomatic C9orf72 mutation carriers METHODS Asymptomatic C9orf72 expansion carriers between 2017 and 2022 (n = 28 non‐carriers, 16 expansion‐positive), underwent dual ...
Rebekah M. Ahmed, Nga Yan Tse, Martina Bocchetta, Carol Dobson‐Stone, John B. Kwok, John R. Hodges, Muireann Irish, Jonathan R. Rohrer, Olivier Piguet, Glenda Halliday   +9 more
wiley   +1 more source

Food intake regulation during pregnancy and lactation in mice with reduced activity of the melanocortin system

Вавиловский журнал генетики и селекции, 2016
Hypothalamic melanortin receptor (MCR) activation inhibits appetite. Neuropeptide Y (NPY) and Agouti Related Protein (AgRP) are coexpressed in some hypothalamic neurons and stimulate feeding, NPY via inhibition of MCR-expressing neurons, and AgRP via ...
E. N. Makarova, I. V. Romanova, N. M. Bazhan   +2 more
doaj   +1 more source

Editorial: Glucosensing impact on glucose metabolism: From fish to mammals

Frontiers in Endocrinology, 2023
Xiao-Chen Yuan, Ya-Xiong Tao
doaj   +1 more source

Effects of Agouti Related Protein and Androgens on Growth

Journal of Applied Sciences, 2003
A dominant mutation at the agouti locus on mouse chromosome 2 is a promoter of overeating and increased linear growth. Agouti related protein, which can be produced using bacteria can be used to reproduce the same growing effect. Androgens are known to promote leanness and increased growth.
openaire   +1 more source

Feeding Rhythm-Induced Hypothalamic Agouti-Related Protein Elevation via Glucocorticoids Leads to Insulin Resistance in Skeletal Muscle. [PDF]

Int J Mol Sci, 2021
Shiuchi T, Otsuka A, Shimizu N, Chikahisa S, Séi H.   +4 more
europepmc   +1 more source

Emerging Signaling Pathway in Arcuate Feeding-Related Neurons: Role of the Acbd7

Frontiers in Neuroscience, 2017
The understanding of the mechanisms whereby energy balance is regulated is essential to the unraveling of the pathophysiology of obesity. In the last three decades, focus was put on the metabolic role played by the hypothalamic neurons expressing ...
Damien Lanfray, Denis Richard
doaj   +1 more source

Sucrose overconsumption impairs AgRP neuron dynamics and promotes palatable food intake

Cell Reports
Summary: Rapid gut-brain communication is critical to maintain energy balance and is disrupted in diet-induced obesity. In particular, the role of carbohydrate overconsumption in the regulation of interoceptive circuits in vivo requires further ...
Carolyn M. Lorch, Nikolas W. Hayes, Jessica L. Xia, Stefan W. Fleps, Hayley E. McMorrow, Haley S. Province, Joshua A. Frydman, Jones G. Parker, Lisa R. Beutler   +8 more
doaj   +1 more source

Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression

Neurosignals, 2012
Activation of mammalian target of rapamycin 1 (mTORC1) by nutrients, insulin and leptin leads to appetite suppression (anorexia). Contrastingly, increased AMP-activated protein kinase (AMPK) activity by ghrelin promotes appetite (orexia).
Kenneth R. Watterson, Dawn Bestow, Jennifer Gallagher, D. Lee Hamilton, Fiona B. Ashford, Paul J. Meakin, Michael L.J. Ashford   +6 more
doaj   +1 more source

Discovery of Molecular Interactions of the Human Melanocortin-4 Receptor (hMC4R) Asp189 (D189) Amino Acid with the Endogenous G-Protein-Coupled Receptor (GPCR) Antagonist Agouti-Related Protein (AGRP) Provides Insights to AGRP's Inverse Agonist Pharmacology at the hMC4R. [PDF]

ACS Chem Neurosci, 2021
Ericson MD, Haslach EM, Schnell SM, Freeman KT, Xiang ZM, Portillo FP, Speth R, Litherland SA, Haskell-Luevano C.   +8 more
europepmc   +1 more source