Results 91 to 100 of about 12,122 (173)

Cellular and metabolic function of GIRK1 potassium channels expressed by arcuate POMC and NPY/AgRP neurons

Molecules and Cells
: It is well known that the G protein-gated inwardly rectifying K+ (GIRK) channels are critical to maintain excitability of central neurons. GIRK channels consist of 4 subunits and GIRK1/GIRK2 heterotetramers are considered to be the neuronal prototype ...
Yeeun Choi, Eun-Seon Yoo, Youjin Oh, Jong-Woo Sohn   +3 more
doaj   +1 more source

UCP2 mediates mitochondrial dynamics to induce AgRP neuronal activity

Molecular Metabolism
Objectives: The hypothalamic agouti-related protein (AgRP)- expressing neurons regulate feeding and whole-body energy homeostasis. A growing body of evidence indicates that changes in mitochondrial dynamics, such as fission and fusion, play a crucial ...
Sungho Jin, Nal Ae Yoon, Zhong-Wu Liu, Ciro Menale, Jung Dae Kim, Nadia Diano, Sabrina Diano   +6 more
doaj   +1 more source

Opioidergic signaling contributes to food-mediated suppression of AgRP neurons

Cell Reports
Summary: Opioids are generally known to promote hedonic food consumption. Although much of the existing evidence is primarily based on studies of the mesolimbic pathway, endogenous opioids and their receptors are widely expressed in hypothalamic appetite
Nilufer Sayar-Atasoy, Yavuz Yavuz, Connor Laule, Chunyang Dong, Hyojin Kim, Jacob Rysted, Kyle Flippo, Debbie Davis, Iltan Aklan, Bayram Yilmaz, Lin Tian, Deniz Atasoy   +11 more
doaj   +1 more source

Agouti-Related Protein [PDF]

, 2020
openaire   +1 more source

FTO promotes weight gain via altering Kif1a splicing and axonal vesicle trafficking in AgRP neurons

The EMBO Journal
N6-methyladenosine (m6A) is an abundant chemical RNA modification involved in the regulation of many biological processes. The m6A demethylase FTO (fat mass and obesity-associated protein) is known to affect body weight, but its systemic context and ...
Daisuke Kohno, Reika Kawabata-Iwakawa, Sotaro Ichinose, Shigetomo Suyama, Kazuto Ohashi, Winda Ariyani, Tetsushi Sadakata, Hiromi Yokota-Hashimoto, Ryosuke Kobayashi, Takuro Horii, Vina Yanti Susanti, Ayumu Konno, Haruka Tsuneoka, Chiharu Yoshikawa, Sho Matsui, Akihiro Harada, Toshihiko Yada, Izuho Hatada, Hirokazu Hirai, Masahiko Nishiyama, Tsutomu Sasaki, Tadahiro Kitamura   +21 more
doaj   +1 more source

Incorporation of Agouti-Related Protein (AgRP) Human Single Nucleotide Polymorphisms (SNPs) in the AgRP-Derived Macrocyclic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-dPro] Decreases Melanocortin-4 Receptor Antagonist Potency and Results in the Discovery of Melanocortin-5 Receptor Antagonists. [PDF]

J Med Chem, 2020
Koerperich ZM, Ericson MD, Freeman KT, Speth RC, Pogozheva ID, Mosberg HI, Haskell-Luevano C.   +6 more
europepmc   +1 more source

Interactions between SNP Alleles at Multiple Loci Contribute to Skin Color Differences between Caucasoid and Mongoloid Subjects

International Journal of Biological Sciences, 2008
This study aimed to identify single nucleotide polymorphism (SNP) alleles at multiple loci associated with racial differences in skin color using SNP genotyping.
Sumiko Anno, Takashi Abe, Takushi Yamamoto
doaj  

Agouti-Related Protein 2 Is a New Player in the Teleost Stress Response System. [PDF]

Curr Biol, 2019
Shainer I, Michel M, Marquart GD, Bhandiwad AA, Zmora N, Ben-Moshe Livne Z, Zohar Y, Hazak A, Mazon Y, Förster D, Hollander-Cohen L, Cone RD, Burgess HA, Gothilf Y.   +13 more
europepmc   +1 more source

Diurnal Patterns for Cortisol, Cortisone and Agouti-Related Protein in Human Cerebrospinal Fluid and Blood.

J Clin Endocrinol Metab, 2020
Panigrahi SK, Toedesbusch CD, McLeland JS, Lucey BP, Wardlaw SL.   +4 more
europepmc   +1 more source

Regulation of Agouti-Related Protein and Pro-Opiomelanocortin Gene Expression in the Avian Arcuate Nucleus. [PDF]

Front Endocrinol (Lausanne), 2017
Boswell T, Boswell T, Dunn IC.
europepmc   +1 more source