Results 111 to 120 of about 339,684 (208)

Opioidergic signaling contributes to food-mediated suppression of AgRP neurons

Cell Reports
Summary: Opioids are generally known to promote hedonic food consumption. Although much of the existing evidence is primarily based on studies of the mesolimbic pathway, endogenous opioids and their receptors are widely expressed in hypothalamic appetite
Nilufer Sayar-Atasoy, Yavuz Yavuz, Connor Laule, Chunyang Dong, Hyojin Kim, Jacob Rysted, Kyle Flippo, Debbie Davis, Iltan Aklan, Bayram Yilmaz, Lin Tian, Deniz Atasoy   +11 more
doaj   +1 more source

Agouti-Related Protein [PDF]

, 2020
openaire   +1 more source

Loops and Links: Structural Insights into the Remarkable Function of the Agouti-Related Protein

, 2003
The agouti-related protein (AGRP) is an endogenous antagonist of the melanocortin receptors MC3R and MC4R found in the hypothalamus and exhibits potent orexigenic activity. The cysteine-rich C-terminal domain of this protein, corresponding to AGRP(87–132)
JOE C. McNULTY, Gantz, Ira, GLENN L. MILLHAUSER, McNulty, Joe C., Barsh, Gregory S., PILGRIM J. JACKSON, Jackson, Pilgrim J., IRA GANTZ, Millhauser, Glenn L., GREGORY S. BARSH, DARREN A. THOMPSON, Thompson, Darren A.   +11 more
core   +1 more source

FTO promotes weight gain via altering Kif1a splicing and axonal vesicle trafficking in AgRP neurons

The EMBO Journal
N6-methyladenosine (m6A) is an abundant chemical RNA modification involved in the regulation of many biological processes. The m6A demethylase FTO (fat mass and obesity-associated protein) is known to affect body weight, but its systemic context and ...
Daisuke Kohno, Reika Kawabata-Iwakawa, Sotaro Ichinose, Shigetomo Suyama, Kazuto Ohashi, Winda Ariyani, Tetsushi Sadakata, Hiromi Yokota-Hashimoto, Ryosuke Kobayashi, Takuro Horii, Vina Yanti Susanti, Ayumu Konno, Haruka Tsuneoka, Chiharu Yoshikawa, Sho Matsui, Akihiro Harada, Toshihiko Yada, Izuho Hatada, Hirokazu Hirai, Masahiko Nishiyama, Tsutomu Sasaki, Tadahiro Kitamura   +21 more
doaj   +1 more source

RING finger protein 17 (Rnf17) of Myc/Max/Mxd network: expression and function during mouse reproduction and development

, 2013
The preimplantation mammalian embryo is sensitive to the environment in which they develop and grow, either in vivo or in vitro. Disturbance to embryo environmental conditions can affect embryo growth.
Bakheet, Ayat
core  

Interactions between SNP Alleles at Multiple Loci Contribute to Skin Color Differences between Caucasoid and Mongoloid Subjects

International Journal of Biological Sciences, 2008
This study aimed to identify single nucleotide polymorphism (SNP) alleles at multiple loci associated with racial differences in skin color using SNP genotyping.
Sumiko Anno, Takashi Abe, Takushi Yamamoto
doaj  

Agouti-Related Protein 2 Is a New Player in the Teleost Stress Response System. [PDF]

Curr Biol, 2019
Shainer I, Michel M, Marquart GD, Bhandiwad AA, Zmora N, Ben-Moshe Livne Z, Zohar Y, Hazak A, Mazon Y, Förster D, Hollander-Cohen L, Cone RD, Burgess HA, Gothilf Y.   +13 more
europepmc   +1 more source

Agouti Mice Models to Study the Diabetogenicity of FK506 (Tacrolimus)

, 2001
Dominant mutations in the promoter region of the mouse agouti gene lead to a syndrome characterized by agouti yellow coat color, obesity, hyperinsulinemia, hyperglycemia, type II diabetes and increased linear growth. The mechanism of agouti modulation of
Joshi, Rashika
core  

Incorporation of Agouti-Related Protein (AgRP) Human Single Nucleotide Polymorphisms (SNPs) in the AgRP-Derived Macrocyclic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-dPro] Decreases Melanocortin-4 Receptor Antagonist Potency and Results in the Discovery of Melanocortin-5 Receptor Antagonists. [PDF]

J Med Chem, 2020
Koerperich ZM, Ericson MD, Freeman KT, Speth RC, Pogozheva ID, Mosberg HI, Haskell-Luevano C.   +6 more
europepmc   +1 more source

Expression of parathyroid hormone-related protein in gastrointestinal malignancies.

, 2006
Parathyroid hormone-related protein (PTHrP) is a peptide hormone which, when abundantly produced by certain tumours, and released into the systemic circulation, stimulates via an endocrine-like pathway, bone resorption and renal calcium reabsorption, by ...
McStay, M.K.G.
core